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Protein ZEB1 promotes breast tumor resistance to radiation therapy
Date:8/4/2014

esponds to wound healing and it is believed that cancer has found a method for using EMT to promote tumor progression.

ZEB1 achieves this unfortunate result through a complex chain of events that permit a gene known as ATM to stabilize the protein Chk1 that plays an important role in DNA damage response. ZEB1 promotes Chk1's ability to allow tumor radioresistance through deployment of an enzyme called USP7.

The hope is that new approaches to addressing radiation resistance may be developed through gaining better insight into how this signaling pathway keeps tumor cells growing despite being bombarded with toxic radiation treatments.

"Radiation therapy plays a key role in breast cancer management," said Ma. "To overcome the obstacle of radioresistant tumor cells, it is important to identify the critical causes and to develop safe and effective new methods for treatment including the possible use of agents that target ZEB1 and which inhibit CHK1."


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Contact: Ron Gilmore
rlgilmore1@mdanderson.org
713-745-1898
University of Texas M. D. Anderson Cancer Center
Source:Eurekalert  

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Protein ZEB1 promotes breast tumor resistance to radiation therapy
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