Navigation Links
Protein Thought to Promote Cancer Does Opposite
Date:7/12/2008

Study finds it functions as a tumor suppressor instead

FRIDAY, July 11 (HealthDay News) -- A protein that appears to suppress the growth of human cancer cells in lab cultures was, until recently, thought to promote colorectal cancer.

Previous animal studies have found that a gene called TCF7L2 is active in about 90 percent of colorectal cancers because of a biochemical malfunction in a gene. As a result, researchers suspected TCF7L2 triggered colorectal cancer in humans.

New technology used by University of Texas Southwestern Medical Center at Dallas researchers, however, allowed them to study the gene on human colorectal cancer cells. When the researchers switched off the TCF7L2 gene, human colorectal cancer cells actually grew stronger and more rapidly in lab cultures.

"This finding reshapes a fundamental model of how colorectal cancer arises," senior study author Lawrence Lum, an assistant professor of cell biology at UT Southwestern, said in a university news release.

The study was published online in this week's issue of the Proceedings of the National Academy of Sciences.

The next step, he said, is to understand more fully all the steps in the biochemical pathway involved in controlling the action of TCF7L2. This may help find new therapeutic targets for treating colorectal cancer.

More information

The American Cancer Society has more about colorectal cancer.



-- Kevin McKeever



SOURCE: University of Texas Southwestern Medical Center at Dallas, news release, July 7, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1

Related medicine news :

1. Pressured proteins: A little pressure in proteomics squeezes 4-hour step into a minute
2. Discovery of key malaria proteins could mean sticky end for parasite
3. Jefferson researchers show antibody to breast cancer-secreted protein blocks metastasis
4. Protein thought to promote cancer instead functions as a tumor suppressor
5. Zinc finger proteins put personalized HIV therapy within reach
6. DSM and Crucell Sign Agreement with Avid Bioservices to Serve as First Pre-Approved U.S. Contract Manufacturer of PER.C6(R) Cell Line Proteins
7. Gene silencer and quantum dots reduce protein production to a whisper
8. Could new discovery about a shape-shifting protein lead to a mighty morpheein bacteria fighter?
9. Alzheimers Protein Tied to HIV Progression
10. Is it time to revisit the current protein recommendations?
11. Lou Gehrigs protein found throughout brain, suggesting effects beyond motor neurons
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Protein Thought to Promote Cancer Does Opposite
(Date:6/26/2016)... ... June 27, 2016 , ... Quality metrics are proliferating in cancer ... they remain in the eye of the beholder, according to experts who offered insights ... American Journal of Managed Care. For the full issue, click here . , ...
(Date:6/26/2016)... (PRWEB) , ... June 26, 2016 , ... ... fertility once they have been diagnosed with endometriosis. These women need a treatment ... also require a comprehensive approach that can help for preservation of fertility and ...
(Date:6/25/2016)... , ... June 25, 2016 , ... First Choice ... States, named Dr. Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm ... Medical Director of our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article published June 14 ... The article goes on to state that individuals are now more comfortable seeking to ... operations such as calf and cheek reduction. The Los Angeles area medical group, Beverly ...
(Date:6/24/2016)... ... , ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys ... peers for this recognition are considered among the top 2 percent of lawyers practicing ... members of this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... Any dentist who has made an implant supported ... Many of them do not even offer this as a ... laboratory costs involved. And those who ARE able to offer ... high cost that the majority of today,s patients would not ... Zadeh , founder of Dental Evolutions Inc. and inventor of ...
(Date:6/23/2016)... ITASCA, Ill. , June 23, 2016  In a startling ... states are failing their residents by lacking a comprehensive, proven plan ... , a definitive ranking of how states are tackling the ... rating to only four states – Kentucky , ... and Vermont . Of the 28 failing states, ...
(Date:6/23/2016)... -- Research and Markets has announced the addition ... - Forecast to 2022" report to their offering. ... to date financial data derived from varied research sources to ... potential impact on the market during the next five years, ... of sub markets, regional and country level analysis. The report ...
Breaking Medicine Technology: