Navigation Links
Protein RAL associated with aggressive characteristics in prostate, bladder and skin cancers
Date:5/17/2012

AURORA, Colo. (May 17, 2012) - We have known for years that when the proteins RalA and RalB are present, cells in dishes copy toward aggressive forms of cancer. However, until this week, no study had explored the effects of RAL proteins in human cancers an essential step on the path to developing drugs to target these proteins. From metastasis in bladder cancer, to seminal vessel involvement in prostate cancer, to shortened survival in squamous cell carcinoma, a study published this week in the journal Cancer Research shows that proteins RalA and RalB are associated with aggressive cancer characteristics in human tumors.

"But here's the interesting part," says Dan Theodorescu, director of the University of Colorado Cancer Center and the paper's senior author "it wasn't the presence of these proteins per se that predicted aggressive cancer characteristics, it was the signature of other genes changed by RAL activity in the cells that predicted poor outcomes."

RalA and RalB activity leads to a cascade of genetic (and gene expression) changes. Theodorescu and colleagues discovered the signature of these changes, and this pattern of turning up and turning down genes is what predicts aggressive cancers.

"It might not be presence of these RAL proteins themselves that drives cancer as much as their ability to drive genetic changes that in turn drive cancer," Theodorescu says.

In the three types of human tumors explored bladder, prostate, and the skin cancer known as squamous cell carcinoma panels of genes affected by RalA and RalB in turn predicted stage and survival.

"The RAL family of GTPases are cousins of the now well-known RAS family of oncogenes," Theodorescu explains. "These RAS family GTPases, are found in leukemias, lung cancer, colon cancer and others, and have been a focus of efforts to develop targeted cancer therapies. We imagine the related RAL family may provide a similar target."

Remove RalA and RalB from cancer cells and perhaps doctors can stop the genetic changes that cause aggressive cancer.


'/>"/>

Contact: Erika Matich
erika.matich@ucdenver.edu
303-524-2780
University of Colorado Denver
Source:Eurekalert

Related medicine news :

1. Protein may represent a switch to turn off B cell lymphoma
2. RANK protein promotes the initiation, progression and metastasis of human breast cancer
3. Protein prevents DNA damage in the developing brain and might serve as a tumor suppressor
4. Unusual protein helps regulate key cell communication pathway
5. Specific protein triggers changes in neurons in brain reward center linked to cocaine addiction
6. Warwick scientists uncover how checkpoint proteins bind chromosomes
7. PI3K/mTOR pathway proteins tied to poor prognosis in breast cancer
8. New discovery of proteins involved in positioning muscular nuclei
9. Tracking proteins behaving badly provides insights for treatments of brain diseases
10. A supercharged protein reduces damage from heart attack
11. Mapping of protein inhibitors facilitates development of tailor-made anticancer agents
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/10/2016)... (PRWEB) , ... February 10, 2016 , ... ... company is unveiling its revolutionary new 2.0 version at the International Roofing Expo ... “put the power of the world's most advanced weather technology in the hands ...
(Date:2/10/2016)... Garland, TX (PRWEB) , ... February 10, 2016 ... ... the commencement of a master charity program created to assist the local community. ... closely with community leaders and nonprofit organizations in the area. Their goal is ...
(Date:2/10/2016)... ... , ... Ongoing news of the ravages of traumatic brain injury (TBI) among ... that takes a closer look at cases of TBI being managed by their members. ... among the aging population, and identifies the challenges associated with their care. , During ...
(Date:2/10/2016)... ... 2016 , ... Armune BioScience signed a definitive agreement with ... centers across the country. Launched in April of 2015, Apifiny is the only cancer ... Apifiny order volume exceeded 3,000 tests in 2015. Primary care physicians and urologists have ...
(Date:2/10/2016)... ... February 10, 2016 , ... The ... been awarded the prestigious Distinguished Emerald Club of the World award, as determined ... magazine, one of the most respected trade publications serving private clubs. , “We’d ...
Breaking Medicine News(10 mins):
(Date:2/10/2016)... Jersey and OR AKIVA, Israel ... Regentis Biomaterials Ltd., a leader in the ... Series D investment round on February 5, 2016. The ... Group ("Haisco"), a leading Chinese pharmaceutical manufacturer, and ... SCP Vitalife Partners, Generali Financial Holdings and both the ...
(Date:2/10/2016)... Feb. 10, 2016  Silicon Biosystems Menarini Inc., ... that help uncover the biological complexities of disease ... a developer of innovative technologies for genomics research, ... aimed at enabling translational researchers to obtain high-quality ... hundred tumor and normal cells in an optimized ...
(Date:2/10/2016)... 2016 On Tuesday, February 9th, the ... with its Arthritis Advisory Committee to discuss ... & Johnson,s Remicade and most likely the ... U.S. The Biologics Prescribers Collaborative (BPC) along ... for Patient Access, American Association of Clinical ...
Breaking Medicine Technology: