Navigation Links
Protein RAL associated with aggressive characteristics in prostate, bladder and skin cancers
Date:5/17/2012

AURORA, Colo. (May 17, 2012) - We have known for years that when the proteins RalA and RalB are present, cells in dishes copy toward aggressive forms of cancer. However, until this week, no study had explored the effects of RAL proteins in human cancers an essential step on the path to developing drugs to target these proteins. From metastasis in bladder cancer, to seminal vessel involvement in prostate cancer, to shortened survival in squamous cell carcinoma, a study published this week in the journal Cancer Research shows that proteins RalA and RalB are associated with aggressive cancer characteristics in human tumors.

"But here's the interesting part," says Dan Theodorescu, director of the University of Colorado Cancer Center and the paper's senior author "it wasn't the presence of these proteins per se that predicted aggressive cancer characteristics, it was the signature of other genes changed by RAL activity in the cells that predicted poor outcomes."

RalA and RalB activity leads to a cascade of genetic (and gene expression) changes. Theodorescu and colleagues discovered the signature of these changes, and this pattern of turning up and turning down genes is what predicts aggressive cancers.

"It might not be presence of these RAL proteins themselves that drives cancer as much as their ability to drive genetic changes that in turn drive cancer," Theodorescu says.

In the three types of human tumors explored bladder, prostate, and the skin cancer known as squamous cell carcinoma panels of genes affected by RalA and RalB in turn predicted stage and survival.

"The RAL family of GTPases are cousins of the now well-known RAS family of oncogenes," Theodorescu explains. "These RAS family GTPases, are found in leukemias, lung cancer, colon cancer and others, and have been a focus of efforts to develop targeted cancer therapies. We imagine the related RAL family may provide a similar target."

Remove RalA
'/>"/>

Contact: Erika Matich
erika.matich@ucdenver.edu
303-524-2780
University of Colorado Denver
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Protein may represent a switch to turn off B cell lymphoma
2. RANK protein promotes the initiation, progression and metastasis of human breast cancer
3. Protein prevents DNA damage in the developing brain and might serve as a tumor suppressor
4. Unusual protein helps regulate key cell communication pathway
5. Specific protein triggers changes in neurons in brain reward center linked to cocaine addiction
6. Warwick scientists uncover how checkpoint proteins bind chromosomes
7. PI3K/mTOR pathway proteins tied to poor prognosis in breast cancer
8. New discovery of proteins involved in positioning muscular nuclei
9. Tracking proteins behaving badly provides insights for treatments of brain diseases
10. A supercharged protein reduces damage from heart attack
11. Mapping of protein inhibitors facilitates development of tailor-made anticancer agents
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/20/2014)... company LunaDress has recently announced its 2015 collection ... discounts on all of its special occasion dresses & wedding ... perfect wedding gown. If you have no idea of what ... Many different wedding dress styles and our dress experts are ... the current special offer, up to 80% off," the CEO ...
(Date:12/20/2014)... (PRWEB) December 20, 2014 DePuy ... a metal-on-metal version of the artificial hip system ... state and federal courts, Bernstein Liebhard LLP reports. ... Bergen County Superior Court on December 2nd, counsel ... begin deposition of plaintiffs on November 19, 2014, ...
(Date:12/20/2014)... The print component of Healthy Aging ... of approximately 160,000 copies and an estimated readership of ... vast social media strategy and across a network of ... digital version of the campaign, click here . ... the ladies of CTV’s The Social. Lainey Lui, ...
(Date:12/20/2014)... News) -- The holidays can be anything but joyous ... trees, scented candles and other allergy triggers. "The ... have been packed away in dank basements or dusty ... patients," Dr. Rachna Shah, an affiliate faculty member at ... Loyola news release. Shah, who is also an ...
(Date:12/20/2014)... December 20, 2014 Recently, VogueQueen.com, a ... VogueQueen Big Sale Online for 2015. Great ... All new and old consumers can get a discount, ... at the company’s website before January 30, 2015. , ... dresses and launched a prom dress promotion. Many customers ...
Breaking Medicine News(10 mins):Health News:2015 Collection of Wedding Dresses from LunaDress Online on Sale Now 2Health News:New Jersey Court Overseeing DePuy Pinnacle Hip Lawsuits Issues New Order, Bernstein Liebhard LLP Reports 2Health News:New Jersey Court Overseeing DePuy Pinnacle Hip Lawsuits Issues New Order, Bernstein Liebhard LLP Reports 3Health News:New Jersey Court Overseeing DePuy Pinnacle Hip Lawsuits Issues New Order, Bernstein Liebhard LLP Reports 4Health News:The ladies of The Social urge Canadian women to put themselves first over the holiday season and into the new year in Mediaplanet’s “Women’s Health” campaign 2Health News:Holiday Trimmings Can Trigger Allergies 2Health News:VogueQueen Big Sale Online For The Coming 2015 2
... Corporation,(Nasdaq: MDTH ) announced that its senior management ... 2008 Health Care Conference,held May 13 - 15 at ... senior management will give its presentation on Tuesday, May,13 ... web cast live over,the Internet via MedCath,s website ( ...
... TORONTO, May 9 /PRNewswire-FirstCall/ - Bradmer Pharmaceuticals ... development and,commercialization of cancer therapies, today announced ... Operational Highlights, During the three ... achieved the,following steps in preparation for the ...
... Two Operations Leads to Indictment of 11,Defendants in ... people have been,indicted in the second phase of ... and health care companies that,fraudulently bill the Medicare ... S. Fisher and U.S. Attorney for the Central,District ...
... May 8 HealthSouth,Corporation (NYSE: HLS ) today ... things, elect directors and provide an update on the,company,s ... More than 88.5% of the outstanding shares eligible ... or by proxy and the board,s,nominated slate of directors ...
... PHOENIX, May 8 NutraCea (OTC Bulletin Board:,NTRZ), ... nutrient research and,technology, announced today that it will ... 12 after the market closes., Management will ... Monday, May,12th to review the first quarter financial ...
... 8 Shortly after the gruesome,discovery of aborted babies ... in early March, Citizens for a Pro-Life Society,discovered the ... Advisory Clinic in Livonia, Michigan, owned by Dr. Reginald ... times in which we live that we,must stop and ...
Cached Medicine News:Health News:Bradmer announces 2008 first quarter operational and financial results 2Health News:Bradmer announces 2008 first quarter operational and financial results 3Health News:Bradmer announces 2008 first quarter operational and financial results 4Health News:Bradmer announces 2008 first quarter operational and financial results 5Health News:Bradmer announces 2008 first quarter operational and financial results 6Health News:Bradmer announces 2008 first quarter operational and financial results 7Health News:Bradmer announces 2008 first quarter operational and financial results 8Health News:Strike Force Targets Medicare Fraud By Los Angeles Area Health Care Companies 2Health News:Strike Force Targets Medicare Fraud By Los Angeles Area Health Care Companies 3Health News:Strike Force Targets Medicare Fraud By Los Angeles Area Health Care Companies 4Health News:Strike Force Targets Medicare Fraud By Los Angeles Area Health Care Companies 5Health News:HealthSouth Board Re-Elected at Annual Shareholder Meeting 2Health News:NutraCea to Host First Quarter 2008 Conference Call on May 12. 2Health News:ALL: More Dead Babies Found in Michigan Dumpsters 2
(Date:12/19/2014)... the Friday, December 19 edition of USA ... (HIT) features Konica Minolta, the company announced today. The supplement will ... healthcare organizations. In addition to the print section ... New York , Chicago , ... Minneapolis and San Francisco , ...
(Date:12/19/2014)... TODAY, AEGATE, the leader in medicine verification ... of Peter Fox as Chief Technology Officer ... Officer. Peter has served as Development Director ... Oracle in 2011. Prior to Datanomic, Peter ... and subsequently Convergys, a world renowned billing system for ...
(Date:12/19/2014)... 2014  Newport Corporation (NASDAQ: NEWP ... joined the company,s Board of Directors.  Dr. Kadia ... director of Evans Analytical Group, a leading global ... services to companies in a wide range of ... Analytical Group, Dr. Kadia spent nine years with ...
Breaking Medicine Technology:USA Today Supplement Featuring Konica Minolta Focuses on Impact of Healthcare IT 2Aegate Appoints new CTO and Chief Channels & Partner Officer 2Aegate Appoints new CTO and Chief Channels & Partner Officer 3Aegate Appoints new CTO and Chief Channels & Partner Officer 4Siddhartha Kadia, Ph.D. Joins Board of Directors of Newport Corporation 2
... term follow up results from chronically infected Hepatitis C,patients strongly confirm and exceed ... to show a statistically significant and long-term ... the way and strongly support move into a second generation, vaccine formulated ... ...
... the risk of,stroke by 34% in patient with atrial fibrillation ... adequately treated by ... of a,post-hoc analysis of the data from the ATHENA study ... European Society of Cardiology,congress 2008, in Munich, Germany. Previous results ...
Cached Medicine Technology:Favourable Six Months Follow-Up Results From Intercell's Phase II Therapeutic Hepatitis C Program 2Favourable Six Months Follow-Up Results From Intercell's Phase II Therapeutic Hepatitis C Program 3Favourable Six Months Follow-Up Results From Intercell's Phase II Therapeutic Hepatitis C Program 4Further Analysis From ATHENA Study Showed That Multaq(R) (dronedarone) Reduced the Risk of Stroke in Patients With Atrial Fibrillation 2Further Analysis From ATHENA Study Showed That Multaq(R) (dronedarone) Reduced the Risk of Stroke in Patients With Atrial Fibrillation 3Further Analysis From ATHENA Study Showed That Multaq(R) (dronedarone) Reduced the Risk of Stroke in Patients With Atrial Fibrillation 4Further Analysis From ATHENA Study Showed That Multaq(R) (dronedarone) Reduced the Risk of Stroke in Patients With Atrial Fibrillation 5
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
Medicine Products: