Navigation Links
Protein Might Mute Effects of Methamphetamine
Date:5/8/2009

Manipulation may be used someday against Parkinson's, too, expert suggests,,

FRIDAY, May 8 (HealthDay News) -- A protein that appears to lend a hand in the death of brain cells tied to Parkinson's disease might also help fight drug addiction, according to a newly published study.

The protein -- organic cation transporter 3, or oct3 -- normally guides molecules in and out of cells, but it seems to lead the toxic brain chemical MPP+ straight to brain cells, where it kills dopamine neurons, which play a key role in helping people move, the study found in a study in mice.

Dead dopamine neurons are a hallmark of Parkinson's, a degenerative disease known for causing tremors and other motor skill issues.

Scientists at Columbia University and the University of Rochester medical centers in New York found that blocking or genetically removing oct3 in mice kept the MPP+ away from the neurons and holed up inside astrocytes, a common type of brain cell that other researchers have linked to Alzheimer's disease, amyotrophic lateral sclerosis (ALS, or Lou Gehrig's disease), epilepsy and other neurological afflictions.

"Astrocytes are definitely much more than support cells in the brain," the study's corresponding author, Kim Tieu, an assistant professor in environmental medicine at Rochester, said in a news release issued by Columbia. "Scientists are discovering their involvement in many diseases. The latest results point to their role in Parkinson's disease."

Astrocytes with active oct3 were found in brain tissue the researchers analyzed from people who had died of Parkinson's, they also reported.

MPP+ is the product of another brain chemical, MPTP, that the astrocytes convert. How and why MPP+ leaves the astrocytes has been a mystery to scientists.

The study, published online in the Proceedings of the National Academy of Sciences, does not theorize about what may be the exact cause of Parkinson's disease, which remains a mostly mysterious illness.

During its research, the team also found that oct3 mutes the high that drug users experience from methamphetamines and similar addictive substances. Oct3 helps astrocytes soak up excess dopamine from around neurons. If not done fast or efficiently enough, the residue of dopamine can give people a euphoric feeling while also causing brain damage. Previous research had found that people with low oct3 activity in their brains are more susceptible to drug addiction.

"How you choose to manipulate the function of oct3 depends on the source of the toxic molecules," Tieu said. "You would try to lessen its effects in a condition where it makes a toxic molecule available to vulnerable cells, as illustrated in the current model of Parkinson's disease. But in the case of drug addiction, you might try to increase it, to lessen the impact of a drug like methamphetamine."

Though no drug exists that can block or boost oct3 in people, the researcher said that finding one might eventually aid people with Parkinson's or drug addiction.

More information

We Move has more about Parkinson's disease.



-- Kevin McKeever



SOURCE: Columbia University Medical Center, news release, May 4, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Omega Protein Reports 2009 First Quarter Results
2. Protein Sciences Corporation Appoints New Board of Directors
3. Upside-down world: DNA protecting protein helps cancer drug to kill cells
4. Novel role of protein in generating amyloid-beta peptide
5. Scripps research scientists model 3D structures of proteins that control human clock
6. Key protein in cellular respiration discovered
7. Protein Might Be a Troublesome Nutrient
8. Protein-Folding Problem May Help Spur Alzheimers
9. Fonterras New ClearProtein(TM) Satiety Water a First for New Zealand Market
10. Blood protein may hold key to stopping tumor growth in cancer patients
11. Bioengineered proteins: Trial confirms new way to tackle cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Protein Might Mute Effects of Methamphetamine
(Date:6/24/2016)... ... ... a crisis. Her son James, eight, was out of control. Prone to extreme mood shifts ... upset him, he couldn’t control his emotions,” remembers Marcy. “If there was a knife ... and say he was going to kill them. If we were driving on the ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA is excited ... To Recovery® program to drive cancer patients to and from their cancer treatments. ... highest quality of life and ongoing independence. Getting to and from medical treatments ...
(Date:6/24/2016)... (PRWEB) , ... June 24, 2016 , ... ... Living, is proud to recognize Dr. Barry M. Weintraub as a prominent plastic ... most beautiful women in the world, and the most handsome men, look naturally ...
(Date:6/24/2016)... ... June 24, 2016 , ... Venture Construction Group (VCG) sponsors ... on June 20th at the Woodmont Country Club at 1201 Rockville Pike, Rockville, Maryland, ... to helping service members that have been wounded in battle and their families. Venture ...
(Date:6/24/2016)... ... 24, 2016 , ... To succeed under value-based payments, healthcare ... unsure how to move forward, given the need to sustain current operations. PYA ... to an organization’s specific needs. , PYA Principal Martie Ross states, “Healthcare providers ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... -- Research and Markets has announced the addition ... - Forecast to 2022" report to their offering. ... to date financial data derived from varied research sources to ... potential impact on the market during the next five years, ... of sub markets, regional and country level analysis. The report ...
(Date:6/23/2016)... Research and Markets has announced the addition of ... their offering. The current ... environment for MedImmune to enter. The US ageing population creates ... drive considerable growth for effective anti-influenza medications. The introduction of ... but development is still in its infancy. ...
(Date:6/23/2016)... , , , WHEN: ... , , , , LOCATION: , , , Online, with ... , EXPERT PANELISTS:  , , , Frost & Sullivan,s Global Vice ... Senior Industry Analyst, Divyaa Ravishankar and Unmesh Lal, Program Manager , ... industry is witnessing an exceptional era. Several new demand spaces, such ...
Breaking Medicine Technology: