Navigation Links
Protein Might Mute Effects of Methamphetamine
Date:5/8/2009

Manipulation may be used someday against Parkinson's, too, expert suggests,,

FRIDAY, May 8 (HealthDay News) -- A protein that appears to lend a hand in the death of brain cells tied to Parkinson's disease might also help fight drug addiction, according to a newly published study.

The protein -- organic cation transporter 3, or oct3 -- normally guides molecules in and out of cells, but it seems to lead the toxic brain chemical MPP+ straight to brain cells, where it kills dopamine neurons, which play a key role in helping people move, the study found in a study in mice.

Dead dopamine neurons are a hallmark of Parkinson's, a degenerative disease known for causing tremors and other motor skill issues.

Scientists at Columbia University and the University of Rochester medical centers in New York found that blocking or genetically removing oct3 in mice kept the MPP+ away from the neurons and holed up inside astrocytes, a common type of brain cell that other researchers have linked to Alzheimer's disease, amyotrophic lateral sclerosis (ALS, or Lou Gehrig's disease), epilepsy and other neurological afflictions.

"Astrocytes are definitely much more than support cells in the brain," the study's corresponding author, Kim Tieu, an assistant professor in environmental medicine at Rochester, said in a news release issued by Columbia. "Scientists are discovering their involvement in many diseases. The latest results point to their role in Parkinson's disease."

Astrocytes with active oct3 were found in brain tissue the researchers analyzed from people who had died of Parkinson's, they also reported.

MPP+ is the product of another brain chemical, MPTP, that the astrocytes convert. How and why MPP+ leaves the astrocytes has been a mystery to scientists.

The study, published online in the Proceedings of the National Academy of Sciences, does not theorize about what may be the exact cause of Parkinson's disease, which remains a mostly mysterious illness.

During its research, the team also found that oct3 mutes the high that drug users experience from methamphetamines and similar addictive substances. Oct3 helps astrocytes soak up excess dopamine from around neurons. If not done fast or efficiently enough, the residue of dopamine can give people a euphoric feeling while also causing brain damage. Previous research had found that people with low oct3 activity in their brains are more susceptible to drug addiction.

"How you choose to manipulate the function of oct3 depends on the source of the toxic molecules," Tieu said. "You would try to lessen its effects in a condition where it makes a toxic molecule available to vulnerable cells, as illustrated in the current model of Parkinson's disease. But in the case of drug addiction, you might try to increase it, to lessen the impact of a drug like methamphetamine."

Though no drug exists that can block or boost oct3 in people, the researcher said that finding one might eventually aid people with Parkinson's or drug addiction.

More information

We Move has more about Parkinson's disease.



-- Kevin McKeever



SOURCE: Columbia University Medical Center, news release, May 4, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Omega Protein Reports 2009 First Quarter Results
2. Protein Sciences Corporation Appoints New Board of Directors
3. Upside-down world: DNA protecting protein helps cancer drug to kill cells
4. Novel role of protein in generating amyloid-beta peptide
5. Scripps research scientists model 3D structures of proteins that control human clock
6. Key protein in cellular respiration discovered
7. Protein Might Be a Troublesome Nutrient
8. Protein-Folding Problem May Help Spur Alzheimers
9. Fonterras New ClearProtein(TM) Satiety Water a First for New Zealand Market
10. Blood protein may hold key to stopping tumor growth in cancer patients
11. Bioengineered proteins: Trial confirms new way to tackle cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Protein Might Mute Effects of Methamphetamine
(Date:1/20/2017)... ... 2017 , ... “Code Word: Chocolate Biscuit”: a biographical account following a man who went on ... of published author, Marlyn Ivey, born in Lynn Haven, Florida and at the age of ... 19 years of age, he joined the Navy and got married right out of boot ...
(Date:1/20/2017)... ... 20, 2017 , ... D R Burton Healthcare Products LLC, ... featured in a study indicating superior performance against competitive products in secretion clearance. ... Oscillating Positive Expiratory Pressure Devices During Simulated Breathing“ was published in the winter ...
(Date:1/20/2017)... ... ... enchanting tale that teaches children the true meaning of Christmas. “Journey to Christmas” is the ... devoted woman of faith. , “Becoming a parent changes you. In my case, the ... years, but actually doing it might have been a while in coming if it hadn’t ...
(Date:1/20/2017)... ... , ... “The Land of More and More”: a brilliant story for ... shares the simple and achievable answer. “The Land of More and More” is the ... Church in Angola, Indiana where he works with the children’s ministry department. , ...
(Date:1/19/2017)... ... 2017 , ... Today, the Centers for Medicare & Medicaid Services (CMS) announced ... Models (APMs) in 2017. Clinicians who participate in APMs are paid for the quality ... the Administration’s effort to build a system that delivers better care and one in ...
Breaking Medicine News(10 mins):
(Date:1/20/2017)... Research and Markets has announced the addition of the ... Amplifiers, Diagnostic Instruments), Sales Volume, Company Analysis and Forecast to ... ... Volume, Company Analysis and Forecast to 2022 provides a comprehensive ... The growing prevalence of hearing impairment coupled with an expanding ...
(Date:1/20/2017)... , Jan. 20, 2017  Palladian Health, ... has announced the launch of an opioid management ... guidelines on opioids and helps stem the growing ... often prescribed to treat chronic non-cancer pain (back ... serious risks and lack of evidence regarding long-term ...
(Date:1/19/2017)... 2017 Germany Cataract Surgery ... new report, "Germany Cataract Surgery Devices Market Outlook to ... Surgery Devices market. The report provides value, in millions ... (USD) within market segements - Phacoemulsification Equipment and Ophthalmic ... shares and distribution shares data for each of these ...
Breaking Medicine Technology: