Navigation Links
Protein Linked With Poor Prognosis in Early-Stage Breast Cancer
Date:1/30/2008

But expression of Ki-67 didn't predict who'd benefit from additional chemo

WEDNESDAY, Jan. 30 (HealthDay News) -- High levels of a protein called Ki-67 are associated with poor prognosis in women with early-stage breast cancer, but this protein may not be useful in identifying patients who would benefit from additional chemotherapy, an Italian study suggests.

Some studies have suggested that breast tumors with a high percentage of tumors cells expressing Ki-67 are more responsive to chemotherapy. This study looked at whether Ki-67 levels predicted responsiveness to chemotherapy in women who'd had surgery for breast cancer.

Researchers at the University of Milan in Italy assessed Ki-67 expression in tumor samples from women in two randomized clinical trials comparing the use of endocrine therapy alone to endocrine therapy after chemotherapy.

They found that Ki-67 expression didn't predict which women would benefit from chemotherapy prior to endocrine therapy, but they did find that having a high percentage of tumor cells expressing Ki-67 was associated with poorer disease-free survival.

"In this study, Ki-67 [expression] was a prognostic factor, not a predictive factor," the study authors wrote.

The findings were published in the Jan. 29 issue of the Journal of the National Cancer Institute.

These results support the position of the American Society of Clinical Oncology Tumor Markers Expert Panel that Ki-67 shouldn't be used to make decisions about chemotherapy, Matthew Ellis, of Washington University in St. Louis, wrote in an accompanying editorial.

"Biomarker studies with negative results can be just as important to publish as those with positive results, because clinging to a long-favored but incorrect hypothesis in the face of negative evidence impedes scientific and clinical progress," Ellis wrote.

More information

Breastcancer.org has mo
'/>"/>

Copyright©2008 ScoutNews,LLC.
All rights reserved  

Page: 1 2

Related medicine news :

1. Draining away brains toxic protein to stop Alzheimers
2. Penn study finds pro-death proteins required to regulate healthy immune function
3. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
4. Emory researchers identify signaling protein for multiple myeloma
5. Human C-reactive protein regulates myeloma tumor cell growth and survival
6. Lowering Blood Protein Wont Help Kidney Patients
7. Blood protein detects lung cancer, even at earliest stage
8. Natural Protein Could Help Spot, Treat Liver Cancer
9. Heat shock proteins are co-opted for cancer
10. How adhesive protein causes malaria
11. Loss of gene leads to protein splicing and buildup of toxic proteins in neurons
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Protein Linked With Poor Prognosis in Early-Stage Breast Cancer
(Date:7/12/2014)... Casinos in Australia have grown ... international and online casinos. Revenue is estimated to increase ... through 2014-15. Greater per capita gambling expenditure has assisted ... in discretionary income levels have also assisted revenue growth, ... such as casino gambling services. Revenue is estimated to ...
(Date:7/12/2014)... July 12, 2014 “After my mom’s stroke, she ... a stroke and loss the use of his left side. Eating ... a way to help people like them enjoy eating again,” said ... prototype for the PATRICIA CAROL HALL PLATE (P C H PLATE). ... a more ergonomic way to eat for individuals who suffer from ...
(Date:7/12/2014)... OH (PRWEB) July 12, 2014 Wright & ... against DePuy Orthopedics , Inc., a subsidiary of Johnson & ... he suffers chronic pain after receiving a metal-on-metal DePuy Pinnacle ... later to remove the artificial hip implant. The DePuy hip ... Court, Northern District of Texas (Case No. 3:14-cv-2427) where ...
(Date:7/12/2014)... July 12, 2014 Dubai is buzzing ... legend is heading to the UAE. The National ... will be in the UAE from 28-31 October to ... support of diabetes awareness. The event is being organized ... and event management company based in Dubai. The announcement ...
(Date:7/12/2014)... 12, 2014 Floor-grade instrument ... 4.1 out of 5. This above-average score represents ... underpinning buyer negotiation power over the three years ... Son, “during the period, surging demand for healthcare ... with new product development, have placed upward pressure ...
Breaking Medicine News(10 mins):Health News:Casinos in Australia Industry Market Research Report Now Updated by IBISWorld 2Health News:Casinos in Australia Industry Market Research Report Now Updated by IBISWorld 3Health News:Casinos in Australia Industry Market Research Report Now Updated by IBISWorld 4Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Ohio Man Who Required Revision Surgery Purportedly From Defective Hip Implant 2Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Ohio Man Who Required Revision Surgery Purportedly From Defective Hip Implant 3Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Ohio Man Who Required Revision Surgery Purportedly From Defective Hip Implant 4Health News:DePuy Pinnacle Hip Lawsuit Filed By Wright & Schulte LLC On Behalf of Ohio Man Who Required Revision Surgery Purportedly From Defective Hip Implant 5Health News:Los Angeles Basketball Legend Headed to Dubai 2Health News:Los Angeles Basketball Legend Headed to Dubai 3Health News:Floor-Grade Instruments Procurement Category Market Research Report from IBISWorld has Been Updated 2Health News:Floor-Grade Instruments Procurement Category Market Research Report from IBISWorld has Been Updated 3Health News:Floor-Grade Instruments Procurement Category Market Research Report from IBISWorld has Been Updated 4
... successfully respond to drugs that combat the AIDS virus can ... level enjoyed by people without HIV, a study published ... sheds light on poorly understood conditions as to why some ... immune cells, others see a slower increase in these key ...
... unwanted baby girls have been drowned in milk, burned alive in ... these days it is much easier to kill them in the ... in a new book on how a traditional preference for sons ... ,India has only 927 females for every 1,000 males ...
... a gene variant that raises a childs risk of ... attributed to inflammation of the gastrointestinal tract . ... a German study that identified the same gene variant ... is a chronic and painful condition attributed to inflammation ...
... a 58-year-old Texan, went for a swim only to ... surgeries, he is still in danger of losing a ... is fighting necrotizing fasciitis, a tissue-destroying disease caused by ... marketing consultant also is suffering from multiple organ failure ...
... than a thousand prisoners has failed to solve the ... rehabilitation programmes, said the BMA today. ,The ... Ministry of Justices introduction of emergency measures designed to ... A key element of the Government strategy was an ...
... belief that male circumcision can reduce HIV infection rates ... will be told next week . ,David ... conference to be held in Sydney from July 22-25, ... in HIV prevention. ,"We always knew that ...
Cached Medicine News:Health News:HIV Drug Combo can Boost Immune Marker in Long-term Patients: Study 2Health News:New Book Gives Gruesome Account of India Girl Killings 2Health News:New Book Gives Gruesome Account of India Girl Killings 3Health News:Gene Variants for Crohn's Disease Identified 2Health News:Gene Variants for Crohn's Disease Identified 3Health News:Texan Battles Flesh-eating Bacteria Contracted While Swimming 2Health News:Prison Healthcare Continues to Fail Despite Emergency Measures, Warns BMA 2Health News:Male Circumcision can Cut HIV Infection, Studies Show 2
(Date:7/10/2014)... DIEGO , July 10, 2014  RESMED INC. (NYSE: ... its fourth quarter and fiscal year ended June 30, 2014 ... Stock Exchange market close. A press release with ResMed,s results ... the company will host a webcast to discuss operating results ... to begin at 1:30 p.m. US Pacific Time and the ...
(Date:7/10/2014)... July 10, 2014  Decision Resources Group finds ... disease (ID) specialists are willing to prescribe Durata,s ... for use as OPAT, approximately two-thirds of the ... to their hospital inpatients. However, our findings indicate ... are initiated on OPAT following hospital discharge, and ...
(Date:1/15/2014)... DALLAS , Jan. 15, 2014 /PRNewswire-iReach/ -- ChinaMarketResearchReports.com ... to its store . (Photo: ... consumption upgrade and policy support, China,s ... the years, with total market size rising from 3.28 ...
Breaking Medicine Technology:ResMed To Announce Fourth Quarter And Fiscal Year-End 2014 Results 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 2Long-Acting Antibiotics Offering Once-Weekly Dosing Will See Favorable Uptake and Use as Outpatient Parenteral Antimicrobial Therapy (OPAT) 3Orthopedic Instrument Industry in China Markets Forecast to 2015 2Orthopedic Instrument Industry in China Markets Forecast to 2015 3
... Pharmacy Technician Certification Board (PTCB) certification ... Technician Workforce Coalition of the Triad continue to ... North Carolina,s evolving healthcare system. The ... local community colleges, was formed to address the ongoing ...
... UNION CITY, Calif., July 19, 2011 Abaxis, Inc. (NasdaqGS: ... has scheduled a conference call to discuss its financial results ... 30, 2011. The call will be at 4:15 p.m. ET ... results for the first quarter of fiscal year 2012 after ...
Cached Medicine Technology:The Pharmacy Technician Workforce Coalition of the Triad and PTCB Position Pharmacy Technicians for Employment 2The Pharmacy Technician Workforce Coalition of the Triad and PTCB Position Pharmacy Technicians for Employment 3Abaxis to Report First Quarter Fiscal Year 2012 Financial Results Thursday, July 28, 2011 2
... X-22 Series is up to 10 inches/ 25 cm ... 11 rotors, the Allegra X-22 Series is the space-saving ... Only 18 inches / 46 cm wide • 11 ... 3 different ways to Spin 1.5 mL & ...
... centrifuges offer high-volume versatility along with a ... them ideal for a wide variety of ... Four- or six-place sealed swinging bucket rotor, ... offered , Lare capacity (4 x 750 ...
... performance centrifuge designed to accommodate over 55 ... refrigerated for heat labile samples. Incorporating the ... capability with automatic quick cooling from 22 ... min, no maintenance brushless motor, low pitch ...
Inquire...
Medicine Products: