Navigation Links
Protein Involved in Addiction Changes Brain Circuitry

Study in rats finds that even one injection leads to dependent behavior

THURSDAY, May 28 (HealthDay News) -- A naturally occurring protein plays a role in the disrupted functioning of the brain's reward circuitry seen in people with drug and alcohol dependence, says a new study.

"If we can understand how the brain's circuitry changes in association with drug abuse, it could potentially suggest ways to medically counteract the effects of dependency," Scott Steffensen, a study co-author and a neuroscientist at Brigham Young University in Provo, Utah, said in a news release.

Previous studies found that chronic drug users can experience an increase of a protein known as brain-derived neurotrophic factor (BDNF) in the brain's reward circuitry. In the new study, the researchers found that a single injection of BDNF made rats behave as if they were dependent on opiates, even though they'd never been given the drugs.

The BDNF injections caused the rats to leave their usual area -- with its comforting smells, lighting and texture -- in search of a fix. The researchers also found that the BDNF injections in the rats caused certain chemicals that normally inhibit neurons in the brain's reward circuitry to excite neurons, which is what happens when people become dependent on drugs.

The finding suggests that BDNF plays a major role in inducing drug dependency, one important aspect of drug addiction, Steffensen said.

The study is published in the May 29 issue of the journal Science.

More information

The U.S. National Institute on Drug Abuse has more about drug abuse and addiction.

-- Robert Preidt

SOURCE: Brigham Young University, news release, May 28, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Page: 1

Related medicine news :

1. Draining away brains toxic protein to stop Alzheimers
2. Penn study finds pro-death proteins required to regulate healthy immune function
3. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
4. Emory researchers identify signaling protein for multiple myeloma
5. Human C-reactive protein regulates myeloma tumor cell growth and survival
6. Lowering Blood Protein Wont Help Kidney Patients
7. Blood protein detects lung cancer, even at earliest stage
8. Natural Protein Could Help Spot, Treat Liver Cancer
9. Heat shock proteins are co-opted for cancer
10. How adhesive protein causes malaria
11. Loss of gene leads to protein splicing and buildup of toxic proteins in neurons
Post Your Comments:
Related Image:
Protein Involved in Addiction Changes Brain Circuitry
(Date:6/25/2016)... ... June 25, 2016 , ... "With 30 hand-drawn hand gesture animations, FCPX ... Austin - CEO of Pixel Film Studios. , ProHand Cartoon’s package transforms over ... Cut Pro X . Simply select a ProHand generator and drag it above media ...
(Date:6/25/2016)... , ... June 25, 2016 , ... As a lifelong ... Cum Laude and his M.D from the David Geffen School of Medicine at UCLA. ... to Los Angeles to complete his fellowship in hematology/oncology at the UCLA-Olive View-Cedars Sinai ...
(Date:6/25/2016)... ... ... On Friday, June 10, Van Mitchell, Secretary of the Maryland Department of Health ... of their exemplary accomplishments in worksite health promotion. , The Wellness at Work Awards ... at the BWI Marriott in Linthicum Heights. iHire was one of 42 businesses to ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... A ... procedures that most people are unfamiliar with. The article goes on to state that ... but also many of these less common operations such as calf and cheek reduction. ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is World Sickle Cell ... pain and the benefits of holistic treatments, Serenity Recovery Center of Marne, ... Cell Disease. , Sickle Cell Disease (SCD) is a disorder of the red blood ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016  In a startling report released today, ... their residents by lacking a comprehensive, proven plan to eliminate prescription ... definitive ranking of how states are tackling the worst drug crisis ... four states – Kentucky , New ... Vermont . Of the 28 failing states, three – ...
(Date:6/23/2016)... , June 23, 2016 ... CAPR ), a biotechnology company focused on ... today announced that patient enrollment in its ongoing ... Duchenne) has exceeded 50% of its 24-patient target. ... in the third quarter of 2016, and to ...
(Date:6/23/2016)... , June 23, 2016 , ... Thursday, July 7, 2016 , , , , LOCATION: , ... , , , , EXPERT PANELISTS:  , , , Frost ... Industry Analyst, Christi Bird; Senior Industry Analyst, Divyaa Ravishankar and Unmesh ... The global pharmaceutical industry is witnessing an exceptional era. Several ...
Breaking Medicine Technology: