Navigation Links
Protein Helps ID Thyroid Cancer Nodules
Date:5/19/2008

Test using galectin-3 finds them sooner, could cut unnecessary surgeries

MONDAY, May 19 (HealthDay News) -- Testing thyroid nodules for the presence of a lectin molecule called galectin-3 could help improve identification of nodules with cancer and reduce the number of unnecessary surgeries, according to an Italian study.

The standard method of determining whether a nodule is malignant is to examine cells extracted by fine-needle aspiration. About 85 percent of thyroid nodules removed by surgery turn out to be benign.

Galectin-3 is not normally present in thyroid cells. When it is present, it can block cell death, leading to the development of cancer, researchers report.

In this study, researchers at St. Andrea Hospital in Rome tested galectin-3 expression in 465 people who were scheduled for surgery to remove thyroid nodules. After the nodules were removed, the final histological results that determined whether they were cancerous or benign were compared to the findings from the galectin-3 testing done before the surgery.

Galectin-3 was not expressed in 331 (71 percent) of 465 nodules. Of those galectin-3-negative nodules, 280 (85 percent) were benign, 29 (9 percent) were cancerous, and the remainder were borderline.

The researchers concluded the sensitivity of the galectin-3 test was 78 percent, the specificity was 93 percent, the positive predictive value was 82 percent, and the negative predictive value was 91 percent.

The findings were published online Monday and in the June issue of The Lancet Oncology.

"The galectin-3 method proposed here does not replace conventional FNA-cytology, but represents a complementary diagnostic method for those follicular nodules that remain indeterminate. The correct approach for this preoperative characterization of thyroid nodules always needs careful multidisciplinary assessment of each patient, according to published guidelines," the study authors wrote.

More information

The American Cancer Society has more about thyroid cancer diagnosis.



-- Robert Preidt



SOURCE: The Lancet Oncology, news release, May 19, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Medical College of Wisconsin researchers identify proteins that help develop mammalian hearts
2. Protein predicts Gleevec resistance in gastrointestinal tumors
3. Carnegie Mellon engineering researchers automate analysis of protein patterns
4. Virus mimics human protein to hijack cell division machinery
5. Naturally-occuring protein may be effective in limiting heart attack injury and restoring function
6. Scientists identify interacting proteins key to melanoma development, treatment
7. Double duty: Loss of protective heart failure protein causes high blood pressure
8. Protein May Trigger Colon Cancer
9. Study in 7,000 men and women ties obesity, inflammatory proteins to heart failure risk
10. First atomic-level look at a protein that causes brain disease
11. OHSU Cancer Institute researcher identifies protein that helps predict prostate cancer survival
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... ... Hannah Randall, PharmD ‘17, and Jennifer Huggins, PharmD ’17, along with clinical ... the primary prevention of cardiovascular diseases during the 15th Annual Women’s Health ...
(Date:10/13/2017)... ... October 13, 2017 , ... Apple Rehab Shelton ... staged a mock evacuation of the facility as part of a disaster drill on ... Echo Hose EMS and Shelton City Emergency Manager, as well as the Connecticut ...
(Date:10/13/2017)... ... October 13, 2017 , ... The Visiting Nurse Association (VNA) of Somerset ... of specialty vendors and unique items from across the nation, this holiday-themed event will ... services offered by the VNA. The boutique will be open Saturday, November 4 ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Global Healthcare Management’s ... Alexandria Park in Milford, NJ. This free event, sponsored by Global Healthcare Management’s ... The fun run is geared towards children of all ages; it is a ...
(Date:10/13/2017)... ... 13, 2017 , ... Talented host, actor Rob Lowe, is ... a new episode of "Success Files," which is an award-winning educational program broadcasted ... each subject in-depth with passion and integrity. , Sciatica occurs when the sciatic ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... 11, 2017  True Health, a leader in ... effort during National Breast Cancer Awareness month to ... Research recently ... that more than 10 million American women are ... BRCA1 or BRCA2 and have not had testing. These ...
(Date:10/7/2017)... Oct. 6, 2017   Provista, a proven ... $100 billion in purchasing power, today announced a new ... The Newsroom is the online home for ... infographics, expert bios, news releases, slideshows and events. ... a wealth of resources at their fingertips, viewers can ...
(Date:10/4/2017)... Oct. 4, 2017 OBP Medical ... illuminating medical devices, today announced regulatory approval from ... Agency (or Agência Nacional de Vigilância Sanitária (ANVISA)) ... cordless surgical retractor with integrated LED light source ... illumination and exposure of a tissue pocket or ...
Breaking Medicine Technology: