Navigation Links
Protein Helps ID Thyroid Cancer Nodules
Date:5/19/2008

Test using galectin-3 finds them sooner, could cut unnecessary surgeries

MONDAY, May 19 (HealthDay News) -- Testing thyroid nodules for the presence of a lectin molecule called galectin-3 could help improve identification of nodules with cancer and reduce the number of unnecessary surgeries, according to an Italian study.

The standard method of determining whether a nodule is malignant is to examine cells extracted by fine-needle aspiration. About 85 percent of thyroid nodules removed by surgery turn out to be benign.

Galectin-3 is not normally present in thyroid cells. When it is present, it can block cell death, leading to the development of cancer, researchers report.

In this study, researchers at St. Andrea Hospital in Rome tested galectin-3 expression in 465 people who were scheduled for surgery to remove thyroid nodules. After the nodules were removed, the final histological results that determined whether they were cancerous or benign were compared to the findings from the galectin-3 testing done before the surgery.

Galectin-3 was not expressed in 331 (71 percent) of 465 nodules. Of those galectin-3-negative nodules, 280 (85 percent) were benign, 29 (9 percent) were cancerous, and the remainder were borderline.

The researchers concluded the sensitivity of the galectin-3 test was 78 percent, the specificity was 93 percent, the positive predictive value was 82 percent, and the negative predictive value was 91 percent.

The findings were published online Monday and in the June issue of The Lancet Oncology.

"The galectin-3 method proposed here does not replace conventional FNA-cytology, but represents a complementary diagnostic method for those follicular nodules that remain indeterminate. The correct approach for this preoperative characterization of thyroid nodules always needs careful multidisciplinary assessment of each patient, according to published guidelines," the study authors wrote.

More information

The American Cancer Society has more about thyroid cancer diagnosis.



-- Robert Preidt



SOURCE: The Lancet Oncology, news release, May 19, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Medical College of Wisconsin researchers identify proteins that help develop mammalian hearts
2. Protein predicts Gleevec resistance in gastrointestinal tumors
3. Carnegie Mellon engineering researchers automate analysis of protein patterns
4. Virus mimics human protein to hijack cell division machinery
5. Naturally-occuring protein may be effective in limiting heart attack injury and restoring function
6. Scientists identify interacting proteins key to melanoma development, treatment
7. Double duty: Loss of protective heart failure protein causes high blood pressure
8. Protein May Trigger Colon Cancer
9. Study in 7,000 men and women ties obesity, inflammatory proteins to heart failure risk
10. First atomic-level look at a protein that causes brain disease
11. OHSU Cancer Institute researcher identifies protein that helps predict prostate cancer survival
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/23/2017)... ... (PRWEB) February 23, 2017 -- ... to come together to combine its favorite springtime pastime – ... fruit – apples! To celebrate National Nutrition Month, the U.S. ... Madness” bracket tournament – a five-week, five-round online competition spotlighting ...
(Date:2/23/2017)... ... February 23, 2017 , ... HealthPostures, the desk for ... expert sit stand solutions representative to the Minneapolis Home and Garden Show which is ... event that is garnering national attention is the Minneapolis Convention Center. , From ...
(Date:2/22/2017)... ... February 22, 2017 , ... Our high-octane society demands higher ... sharpest brain. , Power On, a mental performance enhancer from Modus Nutrition, provides ... Each capsule contains Cognizin® Citicoline, a branded form of the brain health nutrient ...
(Date:2/22/2017)... ... 2017 , ... Secure Exchange Solutions, the leading provider of ... health information exchanges, physicians and patients, announced today that SES Direct earned the ... IT Module Certification via Drummond Group LLC, an Authorized Certification Body (ACB). This ...
(Date:2/22/2017)... ... February 22, 2017 , ... ... accurately understand each Medicare Advantage member’s risk, identify any gaps-in-coding, as well ... solution helps transform the HCC Risk Adjustment process from a typical fragmented ...
Breaking Medicine News(10 mins):
(Date:2/23/2017)... YORK , February 23, 2017 ... states have legalized cannabis for recreational use in 2016. According ... legal cannabis market was worth an estimated $7.2 billion in ... growth rate of 17%. While adult recreational sales are projected ... by 2020, with a 25% CAGR. The market may grow ...
(Date:2/23/2017)... , Feb. 22, 2017 This report analyzes analyzes ... The report provides separate comprehensive analytics for the US, ... Europe , Asia-Pacific , ... estimates and forecasts are provided for the period 2015 through ... markets. Market data and analytics are derived from primary and ...
(Date:2/23/2017)... DEERFIELD, Ill. , Feb. 23, 2017 ... Inc., a wholly-owned subsidiary of Takeda Pharmaceutical Company Limited ... Cambridge Cognition Holdings PLC and Ctrl Group Limited, announced ... designed app on an Apple Watch wearable to monitor ... Disorder (MDD). Depression (MDD) is the leading ...
Breaking Medicine Technology: