Navigation Links
Protein Helps ID Thyroid Cancer Nodules
Date:5/19/2008

Test using galectin-3 finds them sooner, could cut unnecessary surgeries

MONDAY, May 19 (HealthDay News) -- Testing thyroid nodules for the presence of a lectin molecule called galectin-3 could help improve identification of nodules with cancer and reduce the number of unnecessary surgeries, according to an Italian study.

The standard method of determining whether a nodule is malignant is to examine cells extracted by fine-needle aspiration. About 85 percent of thyroid nodules removed by surgery turn out to be benign.

Galectin-3 is not normally present in thyroid cells. When it is present, it can block cell death, leading to the development of cancer, researchers report.

In this study, researchers at St. Andrea Hospital in Rome tested galectin-3 expression in 465 people who were scheduled for surgery to remove thyroid nodules. After the nodules were removed, the final histological results that determined whether they were cancerous or benign were compared to the findings from the galectin-3 testing done before the surgery.

Galectin-3 was not expressed in 331 (71 percent) of 465 nodules. Of those galectin-3-negative nodules, 280 (85 percent) were benign, 29 (9 percent) were cancerous, and the remainder were borderline.

The researchers concluded the sensitivity of the galectin-3 test was 78 percent, the specificity was 93 percent, the positive predictive value was 82 percent, and the negative predictive value was 91 percent.

The findings were published online Monday and in the June issue of The Lancet Oncology.

"The galectin-3 method proposed here does not replace conventional FNA-cytology, but represents a complementary diagnostic method for those follicular nodules that remain indeterminate. The correct approach for this preoperative characterization of thyroid nodules always needs careful multidisciplinary assessment of each patient, according to published guidelines," the study authors wrote.

More information

The American Cancer Society has more about thyroid cancer diagnosis.



-- Robert Preidt



SOURCE: The Lancet Oncology, news release, May 19, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Medical College of Wisconsin researchers identify proteins that help develop mammalian hearts
2. Protein predicts Gleevec resistance in gastrointestinal tumors
3. Carnegie Mellon engineering researchers automate analysis of protein patterns
4. Virus mimics human protein to hijack cell division machinery
5. Naturally-occuring protein may be effective in limiting heart attack injury and restoring function
6. Scientists identify interacting proteins key to melanoma development, treatment
7. Double duty: Loss of protective heart failure protein causes high blood pressure
8. Protein May Trigger Colon Cancer
9. Study in 7,000 men and women ties obesity, inflammatory proteins to heart failure risk
10. First atomic-level look at a protein that causes brain disease
11. OHSU Cancer Institute researcher identifies protein that helps predict prostate cancer survival
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... (PRWEB) , ... March 28, 2017 , ... ... leading physicians, Paul Yost, will begin serving as new board chair for Orange ... month. Yost will serve the remainder of soon-to-be former chair Mark Refowitz’s term, ...
(Date:3/28/2017)... San Francisco, CA (PRWEB) , ... March 28, 2017 , ... ... million people suffering from acne, access to quality care can be limited while the ... skincare company that offers customized prescription acne care for every customer online, today released ...
(Date:3/28/2017)... ... March 28, 2017 , ... The Executives, Staff & Clients ... to for the Toys for Tots Literacy Campaign at their Semi-Annual Graduation and Fundraiser ... $70 billion, the U.S. ranks at number 14 internationally in literacy. Statistically, a direct ...
(Date:3/28/2017)... , ... March 28, 2017 , ... ... be offered by the American Association of Integrative Medicine and available for application ... providers at the AutismOne 2017 Conference in Colorado Springs. , Ed Arranga, president ...
(Date:3/28/2017)... ... March 28, 2017 , ... The ... in Atlantic City March 13-16, was a busy spot this year. Liz Solovay ... discussed strategies for preventing outbreaks among camp communities during the upcoming 2017 camping ...
Breaking Medicine News(10 mins):
(Date:3/27/2017)... LONDON , March 27, 2017 ... require to better understand Eli Lilly and its partnering interests ... Alliance since 2010 report provides an in-depth insight into the ... companies. On demand company reports are prepared upon ... deal and company data. The report will be ...
(Date:3/27/2017)... March 27, 2017  A recent study at Shriners ... freestanding hospitals in the country dedicated to the treatment ... surgery, concluded that the Surfacide Helios ® UV-C ... in reducing bacterial pathogens not killed by the EVS ... at the American Burn Association,s 49th Annual Meeting in ...
(Date:3/27/2017)... 27, 2017  Cryoport, Inc. (NASDAQ: CYRX, CYRXW) ("Cryoport" ... offer shares of common stock in an underwritten public ... with the Securities and Exchange Commission (the "SEC"). The ... there can be no assurance as to whether or ... the actual size or terms of the offering. Cryoport ...
Breaking Medicine Technology: