Navigation Links
Protein Helps ID Thyroid Cancer Nodules
Date:5/19/2008

Test using galectin-3 finds them sooner, could cut unnecessary surgeries

MONDAY, May 19 (HealthDay News) -- Testing thyroid nodules for the presence of a lectin molecule called galectin-3 could help improve identification of nodules with cancer and reduce the number of unnecessary surgeries, according to an Italian study.

The standard method of determining whether a nodule is malignant is to examine cells extracted by fine-needle aspiration. About 85 percent of thyroid nodules removed by surgery turn out to be benign.

Galectin-3 is not normally present in thyroid cells. When it is present, it can block cell death, leading to the development of cancer, researchers report.

In this study, researchers at St. Andrea Hospital in Rome tested galectin-3 expression in 465 people who were scheduled for surgery to remove thyroid nodules. After the nodules were removed, the final histological results that determined whether they were cancerous or benign were compared to the findings from the galectin-3 testing done before the surgery.

Galectin-3 was not expressed in 331 (71 percent) of 465 nodules. Of those galectin-3-negative nodules, 280 (85 percent) were benign, 29 (9 percent) were cancerous, and the remainder were borderline.

The researchers concluded the sensitivity of the galectin-3 test was 78 percent, the specificity was 93 percent, the positive predictive value was 82 percent, and the negative predictive value was 91 percent.

The findings were published online Monday and in the June issue of The Lancet Oncology.

"The galectin-3 method proposed here does not replace conventional FNA-cytology, but represents a complementary diagnostic method for those follicular nodules that remain indeterminate. The correct approach for this preoperative characterization of thyroid nodules always needs careful multidisciplinary assessment of each patient, according to published guidelines," the study authors wrote.

More information

The American Cancer Society has more about thyroid cancer diagnosis.



-- Robert Preidt



SOURCE: The Lancet Oncology, news release, May 19, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Medical College of Wisconsin researchers identify proteins that help develop mammalian hearts
2. Protein predicts Gleevec resistance in gastrointestinal tumors
3. Carnegie Mellon engineering researchers automate analysis of protein patterns
4. Virus mimics human protein to hijack cell division machinery
5. Naturally-occuring protein may be effective in limiting heart attack injury and restoring function
6. Scientists identify interacting proteins key to melanoma development, treatment
7. Double duty: Loss of protective heart failure protein causes high blood pressure
8. Protein May Trigger Colon Cancer
9. Study in 7,000 men and women ties obesity, inflammatory proteins to heart failure risk
10. First atomic-level look at a protein that causes brain disease
11. OHSU Cancer Institute researcher identifies protein that helps predict prostate cancer survival
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... PurhealthRX , a leading ... Purzorb™ technology. Applying the Purzorb™process to full spectrum CBD oil will revolutionize the rapidly ... CBD form that can be easily incorporated into liquid products, while reducing costs to ...
(Date:10/13/2017)... LUIS OBISPO, Calif. (PRWEB) , ... October 13, 2017 , ... ... Alzheimer’s or dementia. However, many long-term care insurance companies have a waiver for care ... is the 90-day elimination period, when the family pays for care, is often waived, ...
(Date:10/13/2017)... ... ... Yisrayl Hawkins, Pastor and Overseer at The House of Yahweh, has released ... understood books in the Holy Scriptures, Revelation. The Book of Revelation paints a picture ... Many have tossed it off as mere rubbish, but Yisrayl Hawkins says that is ...
(Date:10/13/2017)... ... October 13, 2017 , ... “America On The Brink”: the Christian history ... The Brink” is the creation of published author, William Nowers. Captain Nowers and ... WWII veteran, he spent thirty years in the Navy. Following his career as ...
(Date:10/12/2017)... ... October 12, 2017 , ... ... the demand of today’s consumer and regulatory authorities worldwide. From Children’s to Adults ... tested to meet the highest standard. , These products are also: Gluten ...
Breaking Medicine News(10 mins):
(Date:9/28/2017)... -- Cohen Veterans Bioscience and Early Signal Foundation announce ... home sensors for real-time monitoring of patients with trauma-related ... organization focused on disruptive health solutions for rare disorders ... to record and integrate behavioral, cognitive, physiological and contextual ... ...
(Date:9/23/2017)... 2017 Janssen Biotech, Inc. (Janssen) announced today ... the U.S. Food and Drug Administration (FDA) for the ... the treatment of moderately to severely active rheumatoid arthritis ... are needed to further evaluate the safety of sirukumab ... "We are ...
(Date:9/18/2017)... KALAMAZOO, Mich. , Sept. 18, 2017 /PRNewswire/ ... and OptiMed Specialty Pharmacy of Kalamazoo, Mich. ... a strategic hub service that expedites and streamlines patient ... spirometer, Spiro PD 2.0, and wellness management services.  ... a medical device used to measure lung function for ...
Breaking Medicine Technology: