Navigation Links
Protein Gives Doctors New Tool to Detect Melanoma
Date:7/23/2008

Excessive IMP-3, not found in harmless moles, may be key to diagnosis

WEDNESDAY, July 23 (HealthDay News) -- Melanoma produces high levels of a protein called IMP-3, which is not over-expressed in harmless moles, University of Rochester Medical Center researchers report.

They said the finding may offer doctors a new way to distinguish melanoma -- the most dangerous type of skin cancer -- from benign moles that look like melanoma.

The study was published in the current issue of Modern Pathology.

"We are very excited about our finding that IMP-3 is an important progression marker in malignant melanoma," study author Dr. Jennifer G. Pryor, a third-year resident in the department of pathology and laboratory medicine, said in a university news release.

"Although we have learned a lot about melanoma in recent years, it has unique biologic properties that sometimes make it difficult to diagnose and to plan for the proper treatment. This protein may have a key role in helping us to understand and distinguish between various types of melanocytic lesions," Pryor said.

She and her colleagues analyzed samples of 56 biopsied lesions from 48 adults. None of the benign moles over-expressed IMP-3, but excess levels of the protein were found in most melanomas.

IMP-3, which is involved in cell proliferation, appears to play a role in the formation of number of malignant tumors. Previous studies have linked expression of IMP-3 to pancreatic, ovarian and lung cancers. This new study is the first to identify a connection between the protein and melanoma.

Further research is needed to determine if more careful monitoring and aggressive treatment may benefit melanoma patients with tumors that express IMP-3.

More information

The American Academy of Dermatology has more about malignant melanoma.



-- Robert Preidt



SOURCE: University of Rochester, news release, July 17, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Protein Thought to Promote Cancer Does Opposite
2. Pressured proteins: A little pressure in proteomics squeezes 4-hour step into a minute
3. Discovery of key malaria proteins could mean sticky end for parasite
4. Jefferson researchers show antibody to breast cancer-secreted protein blocks metastasis
5. Protein thought to promote cancer instead functions as a tumor suppressor
6. Zinc finger proteins put personalized HIV therapy within reach
7. DSM and Crucell Sign Agreement with Avid Bioservices to Serve as First Pre-Approved U.S. Contract Manufacturer of PER.C6(R) Cell Line Proteins
8. Gene silencer and quantum dots reduce protein production to a whisper
9. Could new discovery about a shape-shifting protein lead to a mighty morpheein bacteria fighter?
10. Alzheimers Protein Tied to HIV Progression
11. Is it time to revisit the current protein recommendations?
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... The American Board of Family ... next President and Chief Executive Officer, succeeding Dr. James C. Puffer upon his retirement. ... 1, 2018 until Dr. Puffer’s retirement at the end of 2018. Upon assuming the ...
(Date:10/13/2017)... , ... October 13, 2017 , ... Apple Rehab ... services, staged a mock evacuation of the facility as part of a disaster drill ... Department, Echo Hose EMS and Shelton City Emergency Manager, as well as the ...
(Date:10/13/2017)... ... October 13, 2017 , ... Yisrayl Hawkins, Pastor and Overseer at The House ... most popular and least understood books in the Holy Scriptures, Revelation. The Book of ... baffled scholars for centuries. Many have tossed it off as mere rubbish, but Yisrayl ...
(Date:10/12/2017)... ... October 12, 2017 , ... First Healthcare Compliance (FHC), ... will showcase a range of technology and learning solutions at the 68th Annual ... Expo to be held October 14–18, 2017 at the Mandalay Bay Resort in ...
(Date:10/12/2017)... (PRWEB) , ... October 12, 2017 , ... The American ... Excellence to Carol Friedman, PhD, FACMI, during the Opening Session of AMIA’s Annual Symposium ... 8. , In honor of Morris F. Collen, a pioneer in the field of ...
Breaking Medicine News(10 mins):
(Date:10/12/2017)... DIEGO , Oct. 12, 2017 AVACEN ... recognized the company with their  2017 New Product Innovation Award ... based on extensive primary and secondary medical device market research ... Medical, through its first-to-market OTC, drug-free pain relief product, the ... unique approach to treating fibromyalgia widespread pain. ...
(Date:10/11/2017)... Texas , Oct. 11, 2017  True ... services, has amplified its effort during National Breast ... about hereditary cancer risks. ... of Clinical Oncology calculated that more than 10 ... have inherited mutations in BRCA1 or BRCA2 and have ...
(Date:10/5/2017)... Ill. , Oct. 5, 2017  In ... Association of Oral and Maxillofacial Surgeons (AAOMS) released ... opioids – to be used as a first-line ... pain. Recognizing ... the AAOMS White Paper "Opioid Prescribing: Acute and ...
Breaking Medicine Technology: