Navigation Links
Protein Gives Clues to Pancreatic Cancer
Date:10/19/2007

When pp32 is gone, a tumor-spurring gene goes to work, researchers say

FRIDAY, Oct. 19 (HealthDay News) -- Researchers say they've identified a protein that could play a key role in the development of pancreatic cancer.

According to a team at the Kimmel Cancer Center at Thomas Jefferson University in Philadelphia, the protein -- called pp32 -- is a tumor-blocker than normally inhibits a cancer-causing gene called K-ras.

However, pp32 is absent in the most aggressive form of pancreatic cancer, the researchers said. More research is required, but pp32 could eventually become a marker for this deadly form of pancreatic cancer and a potential drug target.

In laboratory experiments, the Jefferson team found that when pp32 is absent, mutations in the K-ras gene take over and turn cells cancerous. Adding pp32 to pancreatic cancer cells with K-ras mutations slowed the growth of the fast-growing cells. The researchers concluded that the loss of pp32 may be a key event in determining the aggressiveness of pancreatic cancer.

The study was published online in the journal Modern Pathology.

"If we are able to learn more about this molecule, this may be a potential target that we could turn on in aggressive types of pancreatic cancers," team leader Jonathan Brody, assistant professor of surgery, said in prepared statement. "In theory, if we could find a way to upregulate this molecule in these pancreatic cancers, we may be able to arrest these fast-growing cancer cells as we did in experiments in this study. As we understand its molecular interactions, we could also somehow find the things that regulate it and extend our molecular understanding of this devastating disease."

Previous research had also suggested a link between pp32 and prostate and breast cancer.

More information

The American Cancer Society has more about pancreatic cancer.



-- Robert Preidt



SOURCE: Thomas Jefferson University, news release, October 2007


'/>"/>
Copyright©2007 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Lean Protein Could Be Key to Obesity Drugs
2. Evidence Links Protein Damage to Neurodegenerative diseases like Parkinsons and Alzheimers
3. Special proteins to fight TB identified
4. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of ‘Huntingtons’ Disase
5. Unravelling the secrets of ‘Huntingtin’ Protein - towards the treatment of Huntingtins’ Disese
6. Protein in urine foresees heart disease
7. Obese children may have abnormalities of lipoproteins
8. Dissecting Diabetes - Is protein AKT2 the cause of type 2 diabetes?
9. Protein causing spread of colon cancer identified
10. Protein Complex prevents cancer
11. Protein Fragments Blocking Cures Alzheimers Disease
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2017)... ... 22, 2017 , ... Five Star Glass is new to the Texas market, but is proudly ... glass for most makes and models, in Grand Prairie, TX, located in the center of ... been a family owned business for the past 40 years with 32 convenient locations in ...
(Date:8/22/2017)... ... , ... “To Walk Away”: a captivating and romantic sequel to the ... Walk Away” is the creation of published author, Larry R. Sherman, a retired chemistry ... chemistry and religion, as well as four novels. , Though the book opens ...
(Date:8/22/2017)... , ... August 22, 2017 , ... “Wilderness Voices”: a ... world travel. “Wilderness Voices” is the creation of published author, Martha McKown, an ... McKown was inspired as a very young child when her older sisters studied High ...
(Date:8/22/2017)... ... , ... “Without Love’s Beauty and Pleasures Life Does Not ... while hoping for a better life. “Without Love’s Beauty and Pleasures Life Does ... 13 years working with deprived/neglected adolescents and almost 20 years working with adults ...
(Date:8/22/2017)... ... August 22, 2017 , ... “Covert Awakening”: Walid’s spiritual journey ... author, Julianne Hale, a consultant for the Intelligence Community. For more than ... the Near East region. Julianne has written hundreds of reports for the ...
Breaking Medicine News(10 mins):
(Date:8/2/2017)... -- Life Flight Network and PeaceHealth Oregon Network announced they renewed ... operational efficiency for patients at hospitals in Eugene ... Grove , and Florence, Oregon , ... Network work collaboratively to move patients who require the highest ... sensitive emergency exists. ...
(Date:7/31/2017)... , July 31, 2017  Diplomat Pharmacy, Inc. (NYSE: ... southeast Michigan by Crain,s Detroit ... private and public companies by three-year revenue growth. This year,s ... To view the complete list, visit ... 50 is an incredible triumph," said Phil Hagerman , ...
(Date:7/28/2017)... Hill-Rom Holdings, Inc. ("Hill-Rom") (NYSE: HRC), today ... June 30, 2017, and updated its financial outlook for ... For the fiscal third quarter, Hill-Rom reported earnings of ... share in the prior-year period. These results reflect after-tax ... share primarily related to the non-cash write-down of assets ...
Breaking Medicine Technology: