Navigation Links
Protein-Folding Problem May Help Spur Alzheimer's

Finding could lead to new target for disease therapy, researchers say

WEDNESDAY, April 1 (HealthDay News) -- A dysfunction in protein folding contributes to nerve cell death in Alzheimer's disease, a finding that could help lead to new treatments, Dutch researchers report.

The presence of tangles of misfolded proteins is believed to contribute to Alzheimer's disease, the experts explained. A process known as the "unfolded protein response" typically protects cells from the toxic effects of accumulated misfolded proteins. But prolonged activation of the unfolded protein response -- such as that seen in Alzheimer's patients -- may result in cell death.

The researchers at the VU University Medical Center in Amsterdam and the University of Amsterdam believed that unfolded protein response contributed to brain damage through its effects on the accumulation of hyperphosphorylated tau, a major component of tangles in the brains of people with Alzheimer's.

The study revealed that markers of the unfolded protein response were expressed in areas of tau accumulation in Alzheimer's patients. The unfolded protein response-related proteins were expressed early, in pre-tangle neurons, but were absent in tangle neurons.

The findings suggest that "unfolded protein response activation occurs at an early stage of neurofibrillary degeneration and ... that the prolonged activation of the [unfolded protein response] is involved in both tau phosphorylation and neurodegeneration in [Alzheimer's disease] pathogenesis ... Future studies will address the therapeutic opportunities of this pathway for the treatment of [Alzheimer's disease] and other tauopathies," the researchers wrote.

The study was published in the April issue of The American Journal of Pathology.

More information

The U.S. National Institute on Aging has more about Alzheimer's disease.

-- Robert Preidt

SOURCE: The American Journal of Pathology, news release, March 25, 2009

Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Drug for cluster headaches may cause heart problems
2. Lack of sleep among new school-goers leads to behavioral, cognitive problems
3. Mother and Daughter Create Lead-Free/Safe Bibs and Solve Messy Mealtime Problems
4. Brain atrophy in elderly leads to unintended racism, depression and problem gambling
5. Take Care of Your Heart Before and After Problems
6. Kids Vaccine Ingredient Not Likely Linked to Neurological Problems
7. Study shows lead-based paint problem isnt isolated to China
8. Childhood TV viewing a risk for behavior problems
9. Kids TV Viewing Tied to Behavioral Problems
10. Postoperative Pain is an Under Appreciated, Under Treated Problem in the United States
11. Message for Activists at Latino National Congreso Convention: Amnesty Will Exacerbate National Problems and Turn the U.S. into Another Mexico
Post Your Comments:
Related Image:
Protein-Folding Problem May Help Spur Alzheimer's
(Date:11/24/2015)... ... November 24, 2015 , ... Dr. Todd S. Afferica, a noted general ... of his patients. Dr. Afferica now uses the BIOLASE WaterLase iPlus 2.0™ in many ... the doctor uses other traditional cutting tools, such as the scalpel and high-speed drill, ...
(Date:11/24/2015)... CA (PRWEB) , ... November 24, 2015 , ... ... sizes, has launched their Black Friday sale a week early, offering 40% off ... to transform the intimate apparel industry through both mobile fit technology and the ...
(Date:11/24/2015)... ... 24, 2015 , ... The hospitals and health systems on ... orthopedic care. They have received recognition for excellence from various reputable organizations in ... Becker's Hospital Review selected hospitals for inclusion based on national rankings and awards ...
(Date:11/24/2015)... Berkeley, California (PRWEB) , ... November 24, 2015 ... ... Brillouin Energy's LENR HHT Bolier Reactor System. Brillouin is the developer of renewable ... on controlled low energy nuclear reactions (“LENR”), announced today that its WET™ and ...
(Date:11/24/2015)... ... November 24, 2015 , ... The American Association of Poison ... poison centers through donations on Tuesday, Dec. 1, 2015. Since 2012, the Tuesday ... inspires people to collaborate in improving their local communities and help give back ...
Breaking Medicine News(10 mins):
(Date:11/25/2015)... DUBLIN , Nov. 25, 2015 ... global pharmaceutical company, and Rugen Therapeutics, a start-up ... treatments for unmet CNS disorders and funded by ... that they have entered into an exclusive collaboration ... therapies for Autism Spectrum Disorders (ASD) and Obsessive ...
(Date:11/25/2015)... , Nov. 25, 2015 /PRNewswire/ ... "Company") (NYSE: MR ), a ... medical devices worldwide, today announced that ... general meeting of shareholders at the ... Grand Century, 193 Prince Edward West Road, ...
(Date:11/25/2015)... , November 25, 2015 /PRNewswire/ ... announced the addition of the  "Global ...  report to their offering.  ... the addition of the  "Global Drug ...  report to their offering.  --> ...
Breaking Medicine Technology: