Navigation Links
Protein Examined for Role in Liver Cancer
Date:12/18/2009

Better understanding of TAK1 could lead to new treatments for liver disease, researchers say

THURSDAY, Dec. 17 (HealthDay News) -- A protein switch called TAK1 helps prevent liver damage, including inflammation, fibrosis and cancer, according to a team of scientists from the United States and Japan.

Learning more about how TAK1 works could improve understanding about the development of liver disease and cancer, and lead to new therapies, the researchers noted in their report, released online the week of Dec. 14 in advance of publication in an upcoming print issue of the Proceedings of the National Academy of Sciences.

"TAK1 appears to be a master regulator of liver function," study co-leader Dr. David A. Brenner, a professor of medicine and dean at the University of California San Diego School of Medicine, said in a university news release.

It was already known that TAK1 activates two proteins that play a role in immunity, inflammation, programmed cell death and cancer. But it wasn't clear whether TAK1 promotes or prevents liver cancer.

To investigate this question, Brenner and colleagues created mice with liver cells that lacked TAK1 and found that the mice had a high rate of liver cell death. To compensate, the rodents' livers produced too many cells, resulting in liver damage that led to liver cancer, the researchers found.

More information

The American Liver Foundation has more about liver cancer.



-- Robert Preidt



SOURCE: University of California, San Diego, School of Medicine, news release, Dec. 14, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved

Page: 1

Related medicine news :

1. Low cholesterol transfer protein activity associated with heart disease risk
2. Caltech scientists show how ubiquitin chains are added to cell-cycle proteins
3. Researchers identify proteins in lung cancer cells that may provide potential drug targets
4. Protein from pregnancy hormone may prevent breast cancer
5. Johns Hopkins researchers track down protein responsible for chronic rhinosinusitis with polyps
6. Paradoxical protein might prevent cancer
7. Omega Protein Reports 2009 Third Quarter Results
8. Protein critical for insulin secretion may be contributor to diabetes
9. Blood Protein May Predict Heart Attack But Not Stroke
10. Brain Protein Tied to Retardation
11. Loss of tumor-suppressor and DNA-maintenance proteins causes tissue demise
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/23/2014)... iFitDress.com, a well-known wedding dress manufacturer, has ... . They are now offered at deeply discounted prices, ... from now to Dec. 15. The main purpose of the ... company’s high quality items are ideal options for ladies who ... of money. All its new mint cocktail dresses are very ...
(Date:11/23/2014)... TX (PRWEB) November 23, 2014 ... Devices Market 2006 to 2020 - Asia-Pacific” provides ... energy devices market segments: minimally invasive body contouring ... devices. The analysis includes market size data by ... for the following countries: China, Japan, South Korea, ...
(Date:11/23/2014)... 2014 Pro Ace Care, a renowned Vancouver ... now be providing an 8 year warranty on its selected ... installations went up due to the impending winter season, it ... of the premium service that the company provides. As a ... on John Wood and Bradford hot water tanks. , ...
(Date:11/23/2014)... (HealthDay News) -- Close friends have more influence on ... a new study says. "We,ve known for ... influence on individual alcohol use, but there are no ... and the friend group,s influence on those decisions," Jonathon ... Public Health, said in a university news release. ...
(Date:11/23/2014)... a notable magnetic locks maker, has released a variety ... available at low rates up to 30% off. ... emergency doors. The emergency door adopts fireproof material and ... colors. All of the products are top-quality guaranteed. ... as easy as many people think. As a ...
Breaking Medicine News(10 mins):Health News:Trendy Long Black Evening Gowns Now Provided By iFitDress.com 2Health News:Aesthetic Lasers and Energy Devices Market in APAC (China, Japan, South Korea, Australia and India) to 2020 2Health News:Aesthetic Lasers and Energy Devices Market in APAC (China, Japan, South Korea, Australia and India) to 2020 3Health News:Aesthetic Lasers and Energy Devices Market in APAC (China, Japan, South Korea, Australia and India) to 2020 4Health News:Pro Ace Care Now Gives 8 Year Guarantee on Selected Vancouver Hot Water Tanks 2Health News:Close Friends May Be Key to Teens' Drinking 2
... transplantation of stem cells from a healthy donor (allogeneic) ... aggressive form of chronic lymphocytic leukemia (CLL), irrespective of ... disease. The German CLL Study Group proved this in ... Dr. Peter Dreger, senior consultant and head of the ...
... evaluating the effectiveness of a broad selection of popular ... has found no evidence that any of them facilitate ... presented today (Monday) at the International Congress on Obesity ... effective than the fake supplements they were compared with. ...
... cancer patients who reported poor sleep quality one year after ... dry mouth related to radiation treatments, according to a recent ... Because these side effects can be controlled or modified, the ... cancer patients may be warranted to improve sleep hygiene and ...
... immediate antiretroviral treatment (ART) for infected individuals could have a ... a new study finds that it would not halt the ... a paper that will appear in the August 15 issue ... online, researchers find that the so-called "test-and-treat" strategy could reduce ...
... ... company (Pink Sheets: GDAR), has terminated it,s previously announced strategic alliance with JK Development ... ... Inc., a publicly traded company (Pink Sheets: GDAR), has terminated it,s previously announced strategic ...
... The Kristen Renee ... local campaign set out to fight for the city residents continues to fight for answers ... and BBQ., , ... 9, 2010 -- The Kristen Renee Foundation has launched a campaign to research and investigate ...
Cached Medicine News:Health News:Stem cell transplantation of therapy-resistant chronic leukemia successful 2Health News:New research finds no evidence that popular slimming supplements facilitate weight loss 2Health News:New research finds no evidence that popular slimming supplements facilitate weight loss 3Health News:Pain, dry mouth may play role in sleep quality of head and neck cancer patients 2Health News:Pain, dry mouth may play role in sleep quality of head and neck cancer patients 3Health News:Universal HIV testing and immediate treatment could reduce but not eliminate HIV/AIDS epidemic 2Health News:Golden Age Resources, Inc Terminates Alliance with JK Development of Palm Beach County LLC. 2Health News:The Kristen Renee Foundation Continues to Fight for Frederick, MD for Answers from the EPA and Fort Deterick 2Health News:The Kristen Renee Foundation Continues to Fight for Frederick, MD for Answers from the EPA and Fort Deterick 3Health News:The Kristen Renee Foundation Continues to Fight for Frederick, MD for Answers from the EPA and Fort Deterick 4
(Date:11/22/2014)... de noviembre de 2014  BioClinica®, Inc., un ... y tecnologías eClinical, ha indicado un aumento de ... para el seguimiento basado en el riesgo en ... concepto del seguimiento basado en el riesgo más ... de seguimiento o cambio de los métodos de ...
(Date:11/22/2014)... 21, 2014 Research and Markets  has announced ... Industry Report, 2014-2017" report to their offering. ... Chinese recombinant protein drug market has been expanding rapidly ... and the like. During 2005-2013, sales of recombinant protein ... CAGR of 19.1%, and it is projected that ...
(Date:11/21/2014)... SAN DIEGO , Nov. 21, 2014 /PRNewswire/ ... TNDM ), a medical device company and ... today announced a partnership with Tidepool, a non-profit ... an open source software platform that increases diabetes ... the Tidepool Platform, which is currently under development, ...
Breaking Medicine Technology:El 'seguimiento inteligente' consigue un excelente momento 2El 'seguimiento inteligente' consigue un excelente momento 3China Recombinant Protein Drug Industry Report, 2014-2017 2China Recombinant Protein Drug Industry Report, 2014-2017 3Tandem Diabetes Care Announces Partnership with Tidepool to Further Expand Access to Diabetes Device Data 2Tandem Diabetes Care Announces Partnership with Tidepool to Further Expand Access to Diabetes Device Data 3
... Codexis, Inc. (Nasdaq: CDXS ) today announced the ... to be held in New York, NY on May 18-19, ... will appear on a panel titled "Biofuels" scheduled for May ... not been provided by the conference organizers. Further information will ...
... Pa., May 4, 2011 Auxilium Pharmaceuticals, Inc. (Nasdaq: ... will participate in the Bank of America Merrill Lynch ... the Encore at Wynn Las Vegas.  Mr. Armando Anido, ... an overview of the Company and its product pipeline ...
Cached Medicine Technology:Auxilium Pharmaceuticals to Present at the Bank of America Merrill Lynch 2011 Health Care Conference 2Auxilium Pharmaceuticals to Present at the Bank of America Merrill Lynch 2011 Health Care Conference 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: