Navigation Links
Protein Differences May Explain Long-Term HIV Control
Date:11/4/2010

THURSDAY, Nov. 4 (HealthDay News) -- Variations in an immune system protein explain the rare ability of some HIV-infected people to remain healthy without having to take any medications, scientists say.

The finding could help in efforts to develop new HIV treatments and vaccines, the study authors pointed out.

The immune system is able to suppress viral replication and keep viral load at extremely low levels in about one in 300 HIV patients. These patients are called HIV controllers.

U.S. researchers analyzed the genomes of about 1,000 HIV controllers and 2,600 HIV patients with progressive infection. The controllers had variations in five amino acids in a protein called HLA-B, which alerts the immune system to the presence of infection.

The study was conducted by researchers at the Ragon Institute of Massachusetts General Hospital, MIT and Harvard, and from the Broad Institute of MIT and Harvard.

"We found that, of the three billion nucleotides in the human genome, just a handful make the difference between those who can stay healthy in spite of HIV infection and those who, without treatment, will develop AIDS," co-senior author Dr. Bruce Walker, director of the Ragon Institute, said in a Ragon Institute/Broad Institute news release.

"Earlier studies had showed that certain genes involved with the HLA system were important for HIV control. But they couldn't tell us exactly which genes were involved and how they produced this difference," co-senior author Paul de Bakker, of the Broad Institute and Brigham and Women's Hospital in Boston, said in the news release. "Our findings take us not only to a specific protein, but to a part of that protein that is essential to its function."

The study is published online Nov. 4 in the journal Science.

"HIV is slowly revealing its secrets, and this is yet another," Walker said. "Knowing how an effective immune response against HIV is generated is an important step toward replicating that response with a vaccine. We have a long way to go before translating this into a treatment for infected patients and a vaccine to prevent infection, but we are an important step closer."

More information

The U.S. National Institute of Allergy and Infectious Diseases has more about HIV/AIDS.

-- Robert Preidt

SOURCE: Ragon Institute/Broad Institute, news release, Nov. 4, 2010


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. New and Delicious, Almond Butter Filled, Cookie Bites With 35.7% Protein to Help Manage Weight and Build Muscle
2. Research highlights role of protein pair in obesity regulation
3. Urine protein test might help diagnose kidney damage from lupus, UT Southwestern researchers find
4. Smithfield, United Food and Commercial Workers Union, and Food Networks Paula Deen to Deliver 150,000 Servings of Protein to San Francisco Food Bank
5. Protein Sciences Corporation Announces Profitable and Cash Flow Positive Results for 2009 and Management Realignment
6. Protein Appears Key to Intestinal Balance
7. SIBLING proteins may predict oral cancer
8. Damaged protein identified as early diagnostic biomarker for Alzheimers disease in healthy adults
9. Cells of aggressive leukemia hijack normal protein to grow
10. Omega Protein Comments on California Lawsuit Alleging Fish Oil Contaminants
11. Proteins May Predict Spread of Colon Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Protein Differences May Explain Long-Term HIV Control 
(Date:1/18/2017)... West Lebanon, NH (PRWEB) , ... January 18, ... ... announces the launch of the revolutionary Active Brake Technology (ABT), an innovative braking ... and stability. , Active Brake Technology addresses one of the biggest concerns of ...
(Date:1/17/2017)... ... January 17, 2017 , ... Gym Source, America’s leading ... new showroom at South Dixie Hwy in Miami, FL. , “We are elated to ... “The new innovative in-store concept is designed to give clients a seamless and motivating ...
(Date:1/17/2017)... ... January 17, 2017 , ... SunView Software’s Service Smart Technology ... of the Year. , Each year, Pink Elephant recognizes a new product ... to address a specific business problem or opportunity. The award highlights original innovations that ...
(Date:1/17/2017)... ... ... Mirror Mirror Beauty Boutique, Houston’s premiere CoolSculpting provider , is proud ... Rewards Program. Practice founder, Paul Vitenas, MD FACS, is delighted that Mirror Mirror Beauty ... by Zeltiq, CoolSculpting is approved by the Food and Drug Administration as a safe ...
(Date:1/17/2017)... ... January 17, 2017 , ... SensorInsight ®, an Internet ... in the U.S.A. to offer Internet of Things (IoT) solutions based on ... sensor deployments such as monitoring solutions used to detect potentially hazardous conditions in ...
Breaking Medicine News(10 mins):
(Date:1/18/2017)... CAMBRIDGE, Mass. , Jan. 18, 2017  Tarix ... Drug Administration has granted a Rare Pediatric Disease (RPD) ... treatment of Recessive Dystrophic Epidermolysis Bullosa (RDEB), a rare ... for RDEB and treatment is limited to supportive care. ... supplements the Orphan Drug Designation previously granted by the ...
(Date:1/18/2017)... Jan. 18, 2017  Robust competition in the ... discounts on medicine prices, according to a new ... study is among the first to examine the share ... manufacturers, pharmacy benefit managers (PBMs), health plans and other ... study is the first to show what happens when ...
(Date:1/17/2017)... NEW YORK , Jan. 17, 2017 ... Summary GlobalData,s new report, "North America Insulin Delivery ... the North America Insulin Delivery market. The report provides ... and average prices (USD) within market segments - Insulin ... Accessories. The report also provides company shares and ...
Breaking Medicine Technology: