Navigation Links
Protein Branded As Culprit in Mad Cow Disease
Date:6/11/2009

Misfolded protein kicks off brain cell damage, lab study finds

THURSDAY, June 11 (HealthDay News) -- Mad cow disease and similar conditions may start with one protein that somehow goes astray and deprives the healthy brain cells of another essential protein, researchers say.

Mad cow disease is considered a prion disease because it has been found to be tied to the prion protein, or PrP, which normally is found on the surface of many cells -- including those found in the brain. When the amino acids that make up PrP are folded or configured abnormally during their creation, these malfunctioning proteins can end up in other parts of the cell and that is when the trouble begins.

Scientists at the National Institutes of Health (NIH) found that misfolded or mislocated PrP can bind with another protein called Mahogunin, which is thought to be vital to brain cells. The binding appears to reduce the effectiveness of Mahogunin, leading to the death of healthy brain tissue and the onset of neurodegenerative disease. Mad cow disease, formally known as bovine spongiform encephalopathy, occurs when misfolded PrP binds with normal PrP in the body and converts it into more misfolded protein.

"This advance sets the stage for future efforts to develop potential treatments for prion diseases or perhaps to prevent them from occurring," Dr. Duane Alexander, director of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, said in a NIH news release.

The findings, published in the current issue of Cell, were made after NIH scientists noticed similarities to the damage done to brain tissue by prion disease and that occurring in mice deprived of Mahogunin because of a defective gene. Tests done in lab cultures revealed that when misfolded PrP enters cell cytoplasm, it binds to Mahogunin and damages cells in a fashion similar to if the cells have been deprived of Mahogunin.

Previous studies on laboratory mice done by the researchers had found that brain deterioration follows when cytoplasm contains too much PrP.

To further solidify this finding, a subsequent study on mice with Gerstmann-Straussler-Scheinker (GSS) Syndrome -- a rare neurodegenerative disease in which PrP is found in cell cytoplasm -- found that some brain cells lacked Mahogunin in these mice. A similar Mahogunin depletion did not occur if the scientists altered the PrP to avoid contact with the cytoplasm.

"PrP probably interferes with other proteins, too. But our findings strongly suggest that the loss of Mahogunin is an important factor," study co-author Dr. Ramanujan S. Hegde, of the National Institute of Child Health and Human Development's cell biology and metabolism program, said in the news release.

More information

The U.S. Food and Drug Administration has more about mad cow disease.



-- Kevin McKeever



SOURCE: National Institutes of Health, news release, June 11, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Draining away brains toxic protein to stop Alzheimers
2. Penn study finds pro-death proteins required to regulate healthy immune function
3. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
4. Emory researchers identify signaling protein for multiple myeloma
5. Human C-reactive protein regulates myeloma tumor cell growth and survival
6. Lowering Blood Protein Wont Help Kidney Patients
7. Blood protein detects lung cancer, even at earliest stage
8. Natural Protein Could Help Spot, Treat Liver Cancer
9. Heat shock proteins are co-opted for cancer
10. How adhesive protein causes malaria
11. Loss of gene leads to protein splicing and buildup of toxic proteins in neurons
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Protein Branded As Culprit in Mad Cow Disease
(Date:2/12/2016)... ... ... Each year, the American Physical Therapy Association (APTA) offers a Combined Sections Meeting. ... Almost 10,000 physical therapists across the country are expected to attend this annual convention ... field and network with their colleagues. As in years past, HydroWorx is proud ...
(Date:2/12/2016)... ... 2016 , ... Coco Libre, the maker of coconut water beverages with a ... Lounge Event. Coco Libre will offer musicians and celebrities the company’s signature Organic Coconut ... invitation-only gifting suite, held this year at the W Hollywood Hotel, has become a ...
(Date:2/12/2016)... (PRWEB) , ... February 12, 2016 , ... ... Lean Leadership Series at Zuckerberg San Francisco General Hospital on April 5-7. The ... new behaviors and create new habits. The workshops cover a broad range of ...
(Date:2/12/2016)... PITTSBURGH, Pa. (PRWEB) , ... February 12, 2016 , ... ... space heaters. , This winter the West Penn Burn Center, part of ... Fire Company #1, to bring you the “Space Heaters Need Space” campaign. ...
(Date:2/12/2016)... ... ... AssureVest Insurance Group, a locally owned insurance firm with offices serving Washington ... earmarked to purchase computers and software for Mrs. Harrison’s 2nd and 3rd grade special ... low-income area and has more than 60 2nd and 3rd graders with learning disabilities. ...
Breaking Medicine News(10 mins):
(Date:2/11/2016)... - Cardiac Marker Diagnostic ... and Cancer Therapy. - European Point of Care ... - Key Diagnostic Testing Markets. - Molecular ... Genetic Testing. - Molecular Diagnostics in Infectious Disease ... Diagnostic Products World Markets. - Point of Care ...
(Date:2/11/2016)... SAN FRANCISCO , Feb. 11, 2016  Kindred ... focused on saving and improving the lives of pets, ... Technical Section of the New Animal Drug Application (NADA) ... the pivotal field study (KB0120) of Zimeta for the ... by the Company. --> ...
(Date:2/11/2016)... 11, 2016  NOIT™ Research LLC, a private, leading-edge ... Change" campaign to assist needy families in obtaining one ... sold between February 10, 2016 and March 31, 2016, ... family. The NOIT is an auditory stimulus that plays ... language skills. Beth Shier , NOIT ...
Breaking Medicine Technology: