Navigation Links
Protein Branded As Culprit in Mad Cow Disease
Date:6/11/2009

Misfolded protein kicks off brain cell damage, lab study finds

THURSDAY, June 11 (HealthDay News) -- Mad cow disease and similar conditions may start with one protein that somehow goes astray and deprives the healthy brain cells of another essential protein, researchers say.

Mad cow disease is considered a prion disease because it has been found to be tied to the prion protein, or PrP, which normally is found on the surface of many cells -- including those found in the brain. When the amino acids that make up PrP are folded or configured abnormally during their creation, these malfunctioning proteins can end up in other parts of the cell and that is when the trouble begins.

Scientists at the National Institutes of Health (NIH) found that misfolded or mislocated PrP can bind with another protein called Mahogunin, which is thought to be vital to brain cells. The binding appears to reduce the effectiveness of Mahogunin, leading to the death of healthy brain tissue and the onset of neurodegenerative disease. Mad cow disease, formally known as bovine spongiform encephalopathy, occurs when misfolded PrP binds with normal PrP in the body and converts it into more misfolded protein.

"This advance sets the stage for future efforts to develop potential treatments for prion diseases or perhaps to prevent them from occurring," Dr. Duane Alexander, director of the Eunice Kennedy Shriver National Institute of Child Health and Human Development, said in a NIH news release.

The findings, published in the current issue of Cell, were made after NIH scientists noticed similarities to the damage done to brain tissue by prion disease and that occurring in mice deprived of Mahogunin because of a defective gene. Tests done in lab cultures revealed that when misfolded PrP enters cell cytoplasm, it binds to Mahogunin and damages cells in a fashion similar to if the cells have been deprived of Mahogunin.

Previous studies on laboratory mice done by the researchers had found that brain deterioration follows when cytoplasm contains too much PrP.

To further solidify this finding, a subsequent study on mice with Gerstmann-Straussler-Scheinker (GSS) Syndrome -- a rare neurodegenerative disease in which PrP is found in cell cytoplasm -- found that some brain cells lacked Mahogunin in these mice. A similar Mahogunin depletion did not occur if the scientists altered the PrP to avoid contact with the cytoplasm.

"PrP probably interferes with other proteins, too. But our findings strongly suggest that the loss of Mahogunin is an important factor," study co-author Dr. Ramanujan S. Hegde, of the National Institute of Child Health and Human Development's cell biology and metabolism program, said in the news release.

More information

The U.S. Food and Drug Administration has more about mad cow disease.



-- Kevin McKeever



SOURCE: National Institutes of Health, news release, June 11, 2009


'/>"/>
Copyright©2009 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Draining away brains toxic protein to stop Alzheimers
2. Penn study finds pro-death proteins required to regulate healthy immune function
3. New prion protein discovered by Canadian scientists may offer insight into mad cow disease
4. Emory researchers identify signaling protein for multiple myeloma
5. Human C-reactive protein regulates myeloma tumor cell growth and survival
6. Lowering Blood Protein Wont Help Kidney Patients
7. Blood protein detects lung cancer, even at earliest stage
8. Natural Protein Could Help Spot, Treat Liver Cancer
9. Heat shock proteins are co-opted for cancer
10. How adhesive protein causes malaria
11. Loss of gene leads to protein splicing and buildup of toxic proteins in neurons
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Protein Branded As Culprit in Mad Cow Disease
(Date:10/13/2017)... ... , ... As health professionals work to improve their approach to healthcare, there ... more than filling out a survey; in many cases health professionals and patients are ... care and research on the importance of active engagement with patients and members of ...
(Date:10/13/2017)... ... October 13, 2017 , ... The American Board of ... its next President and Chief Executive Officer, succeeding Dr. James C. Puffer upon his ... July 1, 2018 until Dr. Puffer’s retirement at the end of 2018. Upon assuming ...
(Date:10/13/2017)... ... October 13, 2017 , ... PurhealthRX , a leading ... Purzorb™ technology. Applying the Purzorb™process to full spectrum CBD oil will revolutionize the rapidly ... CBD form that can be easily incorporated into liquid products, while reducing costs to ...
(Date:10/13/2017)... (PRWEB) , ... October 13, 2017 , ... Lori R. ... a member of ElderCounsel, a national organization of elder law and special needs planning ... laws and rules. It also provides a forum to network with elder law attorneys ...
(Date:10/13/2017)... ... 2017 , ... Many families have long-term insurance that covers care for a ... waiver for care if the client has a cognitive impairment diagnosis. , “What ... is often waived, so the benefits from their insurance start immediately,” said Mechell Vieira, ...
Breaking Medicine News(10 mins):
(Date:10/7/2017)... , Oct. 6, 2017   Provista, ... more than $100 billion in purchasing power, today announced ... and information. The Newsroom is the online ... industry trends, infographics, expert bios, news releases, slideshows and ... access to a wealth of resources at their fingertips, ...
(Date:10/2/2017)... FLINT, Mich. , Oct. 2, 2017 ... acquired 8th Day Software and Consulting, LLC , ... 8th Day Software, based in Tennessee ... Management LLC. 8th Day expands EnvoyHealth,s service offerings for ... product development. "In ...
(Date:9/28/2017)... 2017 Hill-Rom Holdings, Inc. (NYSE: HRC), will ... and webcast on Friday, November 3, 2017, beginning at ... at approximately 8:30 a.m. (CDT) / 9:30 a.m. (EDT). ... financial performance and guidance for 2018, Hill-Rom executives will ... operational performance, and long-range financial outlook through 2020. ...
Breaking Medicine Technology: