Navigation Links
Protective strategy shields primate ovaries from radiation-therapy-induced damage
Date:2/22/2011

ly and colleagues at Memorial Sloan-Kettering Cancer Institute reported in 2002 that S1P-pretreated female mice that were mated two months after receiving radiotherapy successfully delivered litters of healthy offspring.

Testing this approach in primates presented several challenges, so before attempting a trial in monkeys, the researchers wanted to be sure that S1P would also protect human oocytes. Ovarian tissue from human patients was grafted into immunodeficient mice, and some of the animals were treated with S1P for an hour before the tissue was exposed to radiation. The experiment showed that the resting pool of follicles from which oocytes develop into mature eggs was protected in the S1P-treated animals but was largely depleted in the human grafts not protected with S1P.

Another potential obstacle to bringing this approach from mice to primates is the fact that rodent ovaries are enclosed in a membrane sac, confining any drug injected into the sac to the ovary. Primate ovaries are free of any such enclosure, presenting the risk that any protective agent applied to the ovary might escape and protect tumor cells as well. Fortunately, investigators at the Oregon National Primate Research Center based at OHSU had already developed an implantable miniature pump that could deliver a drug to the ovaries alone.

In the current study, the OHSU team, led by Mary Zelinski, PhD, conducted a series of experiments, the first of which confirmed that delivering S1P directly to the ovaries of rhesus monkeys provided the same sort of protection from radiation effects seen in the earlier mouse studies. Since S1P is a rather unstable molecule that is broken down quickly, the researchers then tried using FTY720, a long-acting S1P-like agent with similar effects that also is approved for the treatment of multiple sclerosis. Treatment with FTY720, also called fingolimod, was even more successful than S1P in protecting monkey ovarian follicles fr
'/>"/>

Contact: Sue McGreevey
smcgreevey@partners.org
617-724-2764
Massachusetts General Hospital
Source:Eurekalert

Page: 1 2 3 4

Related medicine news :

1. Researchers discover second protective role for tumor-suppressor
2. Minnesota Special Registration Review of Atrazine Found Current Regulations are Protective
3. The protective brain hypothesis is confirmed
4. Overprotective parents may impact heart anxiety in adults with congenital heart conditions
5. Protective properties of green tea uncovered
6. Study details how protein made by HPV teams up on and thwarts protective human protein
7. Governor Rendell Proposes Budget With No Tax Increase, More Money for Public Schools, Strategy for Jobs, Plan to Address Future Deficits
8. SOKO Fitness & Spa Group Broadens Geographic Expansion Strategy
9. Keenan Chief Strategy Officer Selected to Join Editorial Board of Payers & Providers
10. Data Strategy Announces SurePath Services Offering for EMC Avamar
11. New strategy produces promising advance in cancer vaccines
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/16/2014)... 16, 2014 Definitive Healthcare ... and healthcare providers, is pleased to announce the ... online database, now available for subscription, features detailed ... health system affiliations. , The Canadian database spans ... intelligence on over 750 hospitals. Each hospital ...
(Date:9/16/2014)... An experimental positron emission tomography (PET) ... a person is still alive, according to a case ... Mount Sinai, and at Molecular Neuroimaging (MNI) LLC in ... Translational Psychiatry. , Specifically, the study results suggest that ... designed to latch onto a protein called tau that ...
(Date:9/16/2014)... Terminsurancevirginia.com has released a new blog ... life insurance for obese clients. , Obese clients ... quotes. It is unlikely for applicants to be denied ... life insurance costs. , Having life insurance is ... Life insurance is available as temporary or permanent coverage ...
(Date:9/16/2014)... (PRWEB) September 16, 2014 Gary F. ... of China, has selected Worldwide Speakers Group for exclusive ... U.S. Secretary of Commerce and Governor of Washington, Locke ... authorities on U.S.-China relations, global expansion, and business growth. ... global competitiveness and how to grow an organization’s global ...
(Date:9/16/2014)... 2014 Representatives with safetyBUILT-IN ( ... the first phase of a safety-culture-development initiative for ... York, and just recently launched Phase II of ... now the third such facility where safetyBUILT-IN has ... safetyBUILT-IN Principal Eric Svendsen, Ph.D. “The first two ...
Breaking Medicine News(10 mins):Health News:Canadian Hospital Database Now Offered by Definitive Healthcare 2Health News:Neuroimaging Technique Identifies Concussion-Related Brain Disease in Living Brain 2Health News:Neuroimaging Technique Identifies Concussion-Related Brain Disease in Living Brain 3Health News:Neuroimaging Technique Identifies Concussion-Related Brain Disease in Living Brain 4Health News:Obese Clients Can Find Affordable No Exam Term Life Insurance at Terminsurancevirginia.com! 2Health News:Gary Locke, Former Ambassador to China, Selects Worldwide Speakers Group for Exclusive Lecture Representation 2Health News:safetyBUILT-IN Leads Safety-Culture Field-Coaching Effort 2
... a virtually eradicated disease that eats through people's skin, ... South America. ,WHO reported that it ... the skin and bone wasting disease Yaws. The disease ... a bacterial infection, can cause debilitating deformations, particularly in ...
... local and international experts, vaulting over a buffer between ... Central province, for the first time. This has created ... Nairobi. ,The buffer was created by the ... Organisation (WHO) and Food and Agricultural Organisation (FAO). ...
... risk of catching bird flu, as the deadly virus is most ... on cats in areas where outbreaks have occurred found that the ... the chilling prospect that the disease could soon easily be spread ... shows that should bird flu ever break out in Britain, cat ...
... predict disease outbreaks may want to tune into more weather ... finding out when an epidemic is imminent because they determine ... ,The techniques can help quicken the response to ... heat wave and global warming is adding urgency to such ...
... of Informatics-led team of researchers has constructed a model ... across the globe// by airliners. ,The study, ... and Containment Intervention," appears in the January issue of ... said to be the world's largest-scale epidemic simulation of ...
... A new study suggests that TEMPE, a topical anesthetic ... treatment for men with premature ejaculation and might be ... study is published in the February issue of the ... UK and Netherlands studied 54 men with premature ejaculation, ...
Cached Medicine News:Health News:Kenya: Alert As Virus Leaps Over Buffer Zone 2Health News:Kenya: Alert As Virus Leaps Over Buffer Zone 3Health News:Cat Owners at Risk of Bird Flu 2Health News:Experts Use Weather to Predict Disease 2Health News:Scientists Assess Risk of Flu Pandemic Spread Via Global Airlines 2Health News:Scientists Assess Risk of Flu Pandemic Spread Via Global Airlines 3Health News:TEMPE Spray Delays Ejaculation 2
(Date:9/16/2014)... Mass. , Sept. 16, 2014  Decision Resources Group finds ... from $14 billion in 2013 to over $18.2 billion in 2023 ... , Germany , Italy ... and Japan . TNF-alpha inhibitors will ... in the RA market, but growth will be constrained and patient ...
(Date:9/16/2014)... 16, 2014 Surgeons at The Children,s Hospital ... case report the first successful use of a SynCardia ... boy with failing Fontan circulation to bridge him to ... years old, the patient received a Fontan circulation procedure ... ventricle. "The Fontan operation is the final planned palliative ...
(Date:9/16/2014)... 16, 2014  Formex, LLC ("Formex"), a ... Mr. Greg Weilersbacher joined Formex as Director of ... Greg Weilersbacher has over ... expertise in Quality Assurance, Facility Validation, GMP ... brings to Formex a diverse wealth of ...
Breaking Medicine Technology:The Rheumatoid Arthritis Drug Market Will Grow to $18.2 Billion in 2023, Driven by the Uptake of Oral Jak Inhibitors and Non TNF-alpha Biologics 2The Rheumatoid Arthritis Drug Market Will Grow to $18.2 Billion in 2023, Driven by the Uptake of Oral Jak Inhibitors and Non TNF-alpha Biologics 313-Year-Old Boy with Failed Fontan Circulation Bridged to Transplant Using the SynCardia Total Artificial Heart, Published in Annals of Thoracic Surgery 213-Year-Old Boy with Failed Fontan Circulation Bridged to Transplant Using the SynCardia Total Artificial Heart, Published in Annals of Thoracic Surgery 3Greg Weilersbacher Joins Formex, LLC As Director of Quality Assurance and Quality Control 2
... and KOS, Greece, June 29, 2007 /PRNewswire/ --,The ... treated patients on REVLIMID (lenalidomide) plus the,steroid dexamethasone ... The data are pooled from two large randomized,controlled ... patients,from nearly 100 clinical sites worldwide. These updated ...
... at the 11th International Myeloma Workshop ... of perifosine in,combination with bortezomib, dexamethasone ... relapsed/refractory multiple,myeloma, and as a single ... NEW YORK, June 29, 2007 /PRNewswire-FirstCall/ ...
Cached Medicine Technology:The European Myeloma Platform Reports New Survival data for,Revlimid Presented at the International Myeloma Workshop in Greece 2Keryx Biopharmaceuticals, Inc. Announces Positive Phase I and Phase,II Data on KRX-0401 in Patients with Relapsed/Refractory Multiple,Myeloma and Waldenstrom's Macroglobulinemia 2Keryx Biopharmaceuticals, Inc. Announces Positive Phase I and Phase,II Data on KRX-0401 in Patients with Relapsed/Refractory Multiple,Myeloma and Waldenstrom's Macroglobulinemia 3Keryx Biopharmaceuticals, Inc. Announces Positive Phase I and Phase,II Data on KRX-0401 in Patients with Relapsed/Refractory Multiple,Myeloma and Waldenstrom's Macroglobulinemia 4Keryx Biopharmaceuticals, Inc. Announces Positive Phase I and Phase,II Data on KRX-0401 in Patients with Relapsed/Refractory Multiple,Myeloma and Waldenstrom's Macroglobulinemia 5Keryx Biopharmaceuticals, Inc. Announces Positive Phase I and Phase,II Data on KRX-0401 in Patients with Relapsed/Refractory Multiple,Myeloma and Waldenstrom's Macroglobulinemia 6Keryx Biopharmaceuticals, Inc. Announces Positive Phase I and Phase,II Data on KRX-0401 in Patients with Relapsed/Refractory Multiple,Myeloma and Waldenstrom's Macroglobulinemia 7
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... a national reference laboratory and a worldwide ... ARUP offers an extensive test menu of ... clinical and anatomic pathology. Owned by the ... more than half of the nation's university ...
Medicine Products: