Navigation Links
Protective bacteria in the infant gut have resourceful way of helping babies break down breast milk
Date:8/13/2012

A research team at the University of California, Davis, has found that important and resourceful bacteria in the baby microbiome can ferret out nourishment from a previously unknown source, possibly helping at-risk infants break down components of breast milk.

Breast milk is amazingly intricate, providing all of the nutrients necessary to sustain and strengthen infants in the first months of life. Moreover, this natural source of nutrition provides protection from infections, allergies and many other illnesses.

Breast milk also promotes the growth of protective bacteria in an infant's intestine. Because breast milk contains glycans (complex sugars) that infants cannot breakdown, it promotes the growth a specific type of bacteria, called bifidobacteria, that can process these glycans. While it is known that bifidobacteria avail themselves of the free glycans in breast milk, it was not known whether these bacteria could also obtain glycans that were linked to proteins. Such proteins are called glycoproteins, and they are abundant in breast milk.

The research team led by David A. Mills at the UC-Davis investigated the ability of bifidobacteria to remove glycans from milk glycoproteins. Their work was recently published in the journal Molecular & Cellular Proteomics.

Mills' group found that specific strains of bifidobacteria possessed enzymes capable of removing glycan groups from glycoproteins, enabling them to use these glycans as an additional food source. Surprisingly, one of the enzymes, EndoBI-1, was able to remove any type of N-linked glycan (glycans attached to proteins by the amino acid asparagine). This is unique among enzymes of this type and may provide a growth advantage for bifidobacteria in the infant intestine because the glycoproteins in breast milk have complex glycans attached.

Mills explains that the ability of EndBI-1 to remove a variety of complex N-linked glycans combined with its unusual heat stability make "this potentially a very useful tool in both food processing and proteomics/pharmaceutical research."

The team's work suggests that bifidobacteria do not primarily feed on the glycans from milk glycoproteins. However, the study did show that under the proper conditions bidfidobacteria can grow when protein-linked glycans are the only energy source.

"One obvious goal of this research is to find ways to translate the benefits provided by milk and bifidobacteria to at risk populations such as premature infants, malnourished children, among many others," Mills says.


'/>"/>

Contact: Angela Hopp
ahopp@asbmb.org
240-283-6614
American Society for Biochemistry and Molecular Biology
Source:Eurekalert

Related medicine news :

1. NIH team describes protective role of skin microbiota
2. Study identifies possible protective blood factors against Type 2 diabetes
3. Not taking gastroprotective drugs prescribed with anti-inflammatory medicines
4. Chronic exposure to staph bacteria may be risk factor for lupus, Mayo study finds
5. Leveraging bacteria in drinking water to benefit consumers
6. AuCoin gets $600,000 to refine new test for deadly bacterial infection melioidosis
7. Researchers unveil molecular details of how bacteria propagate antibiotic resistance
8. TB treatment paradox: Mouse studies show bodys own response helps TB bacteria survive
9. Dietary fiber alters gut bacteria, supports gastrointestinal health
10. New mechanism of bacterial pathogenesis discovered
11. Bacterial Vaginosis Increases Female-to-Male HIV Transmission Risk
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/24/2017)... ... 2017 , ... Veteran Theresa James awoke to the sound of her newly ... “Healing Tears,” James depicts every parent’s worst nightmare, when her three children were violently ... and situations throughout my divorce,” James said. “After the death of my children, I ...
(Date:4/24/2017)... ... ... My T Chai, a South African company that creates a number of ... a popular website specializing in sales of nutritional products. , Chai tea is ... It spread across Asia and Africa quickly, and today recipes vary from region to ...
(Date:4/24/2017)... ... April 24, 2017 , ... In 2017, up to ... approximately 25,000 of them will be malignant.(1) As research into precision medicine continues, ... healthcare model in the diagnosis and treatment of brain tumors. Healthcare facilities that ...
(Date:4/24/2017)... ... 2017 , ... As a former supermodel known for her timeless beauty, Joan ... single women is that she put all the words in her new book, "Manifest ... personal experiences and sparkling sense of humor have inspired her to write a book ...
(Date:4/24/2017)... ... April 24, 2017 , ... ... shows that over the last decade, student well-being has seriously declined. "When disenfranchised ... of formal education, join the Islamic State to turn the historic multi-ethnic and ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... , Tenn. and DALLAS , April ... EndoStim, Inc., announced that the first patients in ... the EndoStim device in the Lower Esophageal Sphincter Stimulation ... a minimally-invasive implantable device designed to provide long-term reflux ... neurostimulation. GERD affects nearly 65 million people ...
(Date:4/19/2017)... , April 19, 2017 ... stimulate an immune response in pets such as ... products are of various types such as Attenuated ... Toxoid Vaccines, DNA Vaccines and Recombinant Vaccines. Attenuated ... as virus or bacteria, which have been weakend ...
(Date:4/19/2017)... 2017  SARES•REGIS Group leased the first of ... Conejo Spectrum Business Park in Thousand ... Inc. , a biopharmaceutical company developing meaningful therapies ... have been underserved by scientific innovation, with an ... autoimmune and infectious disease. Before commencement ...
Breaking Medicine Technology: