Navigation Links
Prostate cancer treatment regret is 52 percent higher in men with cardiovascular disease
Date:7/2/2012

Prostate cancer patients with cardiovascular disease were 52 per cent more likely to regret their treatment choices than men without problems with their heart or veins, according to a study published in the July issue of the urology journal BJUI International.

Research led by Harvard Medical School, USA, looked at 795 men with recurrent cancer in the Comprehensive Observational Multicenter Prostate Adenocarcinoma (COMPARE) registry.

"Treatment regret can have an adverse impact on a patient's overall outlook and has been associated with a poorer global quality of life" says lead author Dr Paul L Nguyen from the Department of Radiation Oncology at Harvard's Dana Farber Cancer Institute and Brigham and Women's Hospital.

"Understanding predictors of regret can help clinicians better counsel patients about their treatments so that later regret can be avoided."

Key findings of the study included:

  • The researchers studied 410 men who had a prostatectomy (surgery), 237 who received external beam radiation therapy, 124 who received brachytherapy (internal radiation) and 24 who received primary androgen deprivation (hormone) therapy. These men experienced recurrence at a median of 5.5 years.

  • Just under a third of the men (31 per cent) had cardiovascular issues such as heart attacks, congestive heart failure, angina, diabetes, stroke or circulation problems. They were slightly older than men without cardiovascular problems (67.6 versus 66.7 years) and were less likely to have undergone surgery as their primary therapy.

  • Just under 15 per cent of the men reported regret and this was 52 per cent higher in men with cardiovascular problems than without.

  • Men with cardiovascular problems were more likely to experience bowel problems than those without cardiovascular issues (44 per cent versus 36 per cent) and urinary problems (46 per cent versus 39 per cent). Men who had bowel problems reported 58 per cent higher levels of regret.

  • Men diagnosed at a younger age were also more likely to regret their choice of treatment

"Most men with localised prostate cancer have multiple treatment options, each with their own set of potential risks and benefits" says Dr Nguyen. "While many patients are grateful for the chance to select their treatment, some may subsequently regret their treatment if the outcomes after therapy do not meet their expectations.

"Our study found that, among men with recurrent prostate cancer, those with cardiovascular health issues were 52 per cent more likely to regret their treatment choice than men without cardiovascular problems. It highlights the growing importance of considering other health issues such as cardiovascular disease when counseling patients about prostate cancer treatment options.

"The clinical implication of the present study is that it provides another rationale for patients with cardiovascular problems and prostate cancer to consider active surveillance, which aims to avoid or delay unnecessary treatment in men with less aggressive cancers. This is because the potential benefit of treatment is relatively small for men with a short life expectancy and the potential for regret is significantly higher.

"Our research also suggests that prostate cancer patients with cardiovascular issues should be alerted to the potential increased risk of post-treatment toxicity, such as bowel problems, as this may help to reduce treatment regret if their cancer returns."


'/>"/>

Contact: Annette Whibley
annette.wizard@gmail.com
Wiley
Source:Eurekalert

Related medicine news :

1. New drug prevents spread of human prostate cancer cells
2. 2 genetic deletions in human genome linked to the development of aggressive prostate cancer
3. Intensity Modulated Radiation Therapy optimal for localized prostate cancer
4. Study examines adverse effects among different radiation therapies for prostate cancer
5. Study Casts Doubt on Value of Pricey Prostate Cancer Therapy
6. Warren Buffett Has Early Stage Prostate Cancer
7. Genetic abnormalities in benign or malignant tissues predict relapse of prostate cancer
8. PSA screening to detect prostate cancer can be beneficial to younger and at-risk men
9. Mayo Clinic researchers discover biomarkers for prostate cancer detection, recurrence
10. Quality of care, other issues may cause worse results in black prostate cancer surgery patients
11. Higher hospital volume more important than surgeon experience in outcome of prostate cancer surgery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/28/2017)... ... March 28, 2017 , ... ... critical to ensuring high-quality results and maintaining GMP and USP compliance. In a ... in accordance with GMP requirements " these requirements are explained. The challenge ...
(Date:3/28/2017)... ... March 28, 2017 , ... With less than 10,000 dermatologists ... to quality care can be limited while the desire to conquer breakouts and eliminate ... acne care for every customer online, today released its inaugural survey on the State ...
(Date:3/28/2017)... Ohio (PRWEB) , ... March 28, 2017 , ... Columbus ... was selected as one of few medical professionals in the country to sit on ... Founder of Juvly Aesthetics, in just 2 years Dr. Harper helped propel the clinic ...
(Date:3/28/2017)... PA (PRWEB) , ... March 28, 2017 , ... Public ... and across a variety of business channels. , While many results are clear, ... any public relations program. , When it comes to measurement, firms should always ...
(Date:3/28/2017)... ... ... a common and unwelcomed occurrence in people of all ages, genders and ethnicities. Dermatologist Dr. ... of dealing with excess skin oil. “Oily skin is a challenge to many of my ... the oily shine while keeping the skin fresh and clean,” says Dr. Au. , What ...
Breaking Medicine News(10 mins):
(Date:3/28/2017)... , March 28, 2017  "US Cancer Generics ... the various indicators and trend analysis related to ... in mainstream pharmaceutical market in US. The report ... the growth on cancer generics drugs in recent ... saving of billions of dollars for various stake ...
(Date:3/28/2017)... -- Orexigen Therapeutics, Inc. (Nasdaq: OREX ) today ... and year ended December 31, 2016. ... Orexigen, beginning with the re-acquisition of the rights to ... team at Orexigen demonstrated remarkable focus, executing on a ... our Company while rewarding us full control of our ...
(Date:3/28/2017)... , March 28, 2017 ... consolidated vendor landscape, with the top three companies, namely ... accounting for a significant 49% of the overall market ... report. The vendor landscape is intensely competitive and has ... the overall market. These factors have restricted the entry ...
Breaking Medicine Technology: