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Prostate cancer study proves drug delays disease progression
Date:1/23/2012

(TORONTO, Canada Jan. 24, 2012) For men diagnosed with low-risk, localized prostate cancer, being treated with the drug dutasteride ("Avodart") delays disease progression and initiating active treatment, and also reduces anxiety, show the results of a three-year international clinical trial led by Dr. Neil Fleshner, Head of the Division of Urology, University Health Network (UHN).

The findings are published online today in The Lancet. "The results prove that using active surveillance plus dutasteride is a viable, safe and effective treatment option for men who often undergo aggressive local treatment despite low risk of dying from the disease," says Dr. Fleshner, a surgical oncologist in UHN's Princess Margaret Cancer Program and Professor of Surgery at the University of Toronto. Dr. Fleshner also holds the Love Chair in Prostate Cancer Prevention Research.

"This is very good news for men with low-risk disease because aggressive treatment can have a major impact on their quality of life, with risks of impotence and incontinence," says Dr. Fleshner.

The three-year clinical trial enrolled 302 men between the ages of 48 and 82 diagnosed with low-risk localized prostate cancer and regularly monitored for clinical changes a treatment option called "active surveillance". In the trial known as REDEEM (REduction by Dutasteride of clinical progression Events in Expectant Management of prostate cancer) participants were randomized 1:1 to receive dutasteride or a matching placebo daily. The men also underwent biopsies at 1.5 and three years.

The study showed a significant delay in disease progression in the men treated with dutasteride 36% compared with 23% who received the placebo. As well, the final biopsies showed the men treated with the drug were less likely to have cancer detected 36% compared with 31%.

"This is the first study to show that a 5a-reductase inhibitor such as dutasteride reduces the ne
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Contact: Jane Finlayson
jane.finlayson@uhn.ca
416-946-2846
University Health Network
Source:Eurekalert

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