Navigation Links
Prostate cancer stem cells are a moving target, UCLA researchers say
Date:12/4/2013

UCLA researchers have discovered how prostate cancer stem cells evolve as the disease progresses, a finding that could help point the way to more highly targeted therapies.

Following recent studies showing that prostate cancer originates in basal stem cells, UCLA researchers were surprised to discover that the cancer eventually begins to grow from a different type of cell called a luminal stem cell. The new discovery indicates that the basal stem cells evolve into luminal stem cells as the cancer grows. Existing prostate cancer drugs are designed to seek out and kill the basal stem cells that give rise to the cancer, so the evolution from basal to luminal stem cells creates a "moving target" that renders the drugs less effective over time.

The study, by Andrew Goldstein, Dr. Owen Witte, Tanya Stoyanova and colleagues from UCLA's Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research and UCLA's Jonsson Comprehensive Cancer Center, was published online by the Proceedings of the National Academy of Sciences and will appear later in the journal's print edition.

Adult stem cells are tissue-specific cells that regenerate and replace diseased or damaged cells in the body's organs. Cancer starts in basal stem cells in the lining of the prostate gland, the epithelium, and they lose their ability to control their growth. Tumors that start as uncontrolled growth in basal stem cells continue to grow from luminal stem cells, another type of cell in the prostate epithelium.

"People have begun to think about cancers as being driven by stem cells in the same way that many of our adult organs are maintained by dedicated stem cells," Goldstein said. "Based on this new understanding, we are excited about going right to the root of the tumor and targeting those stem cells to eradicate the cancer."

Patients with aggressive prostate cancer are often treated with anti-androgens, drugs that block production of hormones such as testosterone that make the cancer more aggressive. The tumor stem cells that remain after the anti-androgen treatment look different from the basal and luminal cells. This means that for treatments that target specific cell types, researchers need to identify the different cell types that evolve as the disease and its treatment progress.

With the knowledge that prostate cancer stem cells can change their physical appearance, or phenotype, from one type of cell to another, the UCLA researchers are now seeking to understand whether certain elements of the stem cells remain consistent even as they evolve from one cell type to another. This knowledge could help scientists develop drugs that target the evolving cancer stem cells by aiming for the elements that remain unchanged.


'/>"/>

Contact: Shaun Mason
smason@mednet.ucla.edu
310-206-2805
University of California - Los Angeles
Source:Eurekalert

Related medicine news :

1. New drug prevents spread of human prostate cancer cells
2. 2 genetic deletions in human genome linked to the development of aggressive prostate cancer
3. Intensity Modulated Radiation Therapy optimal for localized prostate cancer
4. Study examines adverse effects among different radiation therapies for prostate cancer
5. Study Casts Doubt on Value of Pricey Prostate Cancer Therapy
6. Warren Buffett Has Early Stage Prostate Cancer
7. Genetic abnormalities in benign or malignant tissues predict relapse of prostate cancer
8. PSA screening to detect prostate cancer can be beneficial to younger and at-risk men
9. Mayo Clinic researchers discover biomarkers for prostate cancer detection, recurrence
10. Quality of care, other issues may cause worse results in black prostate cancer surgery patients
11. Higher hospital volume more important than surgeon experience in outcome of prostate cancer surgery
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:1/20/2017)... ... January 20, 2017 , ... “Knowledge is God’s Lighthouse”: a ... “Knowledge is God’s Lighthouse” is the creation of published author, Gene Gaapf, a retired ... collections. , “I have been writing since high school and have many different ...
(Date:1/19/2017)... ... January 20, 2017 , ... Today, the Centers for Medicare & ... of CMS’s Alternative Payment Models (APMs) in 2017. Clinicians who participate in APMs are ... an important part of the Administration’s effort to build a system that delivers better ...
(Date:1/19/2017)... Ocala, Florida (PRWEB) , ... January 19, 2017 ... ... multi-million dollar 5,000 SF expansion and facility enhancement of their 503A compounding pharmacy ... To meet the growing demand of physicians and patients throughout the United States ...
(Date:1/19/2017)... ... January 19, 2017 , ... LabRoots , the leading ... the world, announces the launch of its newly redesigned website. The sleek new ... breakthroughs and trending news, vital information on upcoming virtual events and webinars, all ...
(Date:1/19/2017)... CA (PRWEB) , ... January 19, 2017 , ... Cosmetic ... of plastic surgery procedures in order to make it easier for their readers to ... of the body they impact as well as the techniques used on those particular ...
Breaking Medicine News(10 mins):
(Date:1/19/2017)... 2017 Germany Cataract Surgery ... new report, "Germany Cataract Surgery Devices Market Outlook to ... Surgery Devices market. The report provides value, in millions ... (USD) within market segements - Phacoemulsification Equipment and Ophthalmic ... shares and distribution shares data for each of these ...
(Date:1/19/2017)... 19, 2017 Report Details What ... areas are going to grow at the fastest rates? ... assessing data, trends, opportunities and prospects. Our 190-page ... most lucrative areas in the industry and the future ... sales across the all the major categories of the ...
(Date:1/19/2017)... SILVER SPRING, Md. , Jan. 19, 2017 ... for the treatment of Chronic Idiopathic Constipation (CIC) in adult ... patients suffering from chronic gastrointestinal disorders," said Julie Beitz ... in the FDA,s Center for Drug Evaluation and Research. "With ... select the most appropriate treatment for their condition." ...
Breaking Medicine Technology: