Navigation Links
Prostate cancer risk halved for subfertile men
Date:2/1/2012

Involuntary childlessness owing to reduced fertility is a concern for many men. However, these men do have one advantage they run a significantly lower risk of suffering from prostate cancer. Researchers are interested in whether this phenomenon could be used in the fight against cancer.

There is a clear link between male subfertility and a lower risk of prostate cancer. According to a new thesis from Lund University in Sweden, involuntarily childless men have around a 50 per cent lower risk of suffering from prostate cancer than men who have fathered at least one child.

Yasir Ruhayel, a doctoral student at Lund University and doctor at Skne University Hospital, has based his research on the Malm Diet and Cancer population study, where he has compared around 450 men with prostate cancer with an equal number of men in a control group who had not been diagnosed with the disease.

The thesis reinforces the findings of previous register-based studies, which have shown a connection, but this is the first time the issue has been studied in greater detail. An important conclusion is that the connection between reduced prostate cancer risk and subfertility is stronger than the connection between prostate cancer and other factors previously studied, for example diet, smoking, alcohol consumption and a number of different diseases.

Are there genetic explanations?

Yasir Ruhayel has also investigated whether variation in certain genes may be linked to the reduction in prostate cancer risk observed in the subfertile men.

"We have found certain genetic associations, but the results are preliminary and more extensive studies involving a larger number of men are needed before the significance of the genetics can be verified", says Yasir Ruhayel.

One of the identified candidate genes is the AHR gene, which interacts with the male and female sex hormone signalling systems. AHR is also known as the 'dioxin receptor' because it mediates the harmful effects of the environmental toxicant dioxin, which can affect fertility.

If future research is able to more accurately determine which genes reduce the risk of prostate cancer, then this may open up new opportunities to develop drugs. However, before this can happen the genes with the desirable properties must be considered in a broader context, because reduced fertility is usually caused by a number of factors. The cancer-blocking properties must also be separated out and isolated from the properties that reduce fertility.

The researchers at Lund University are also interested in the reverse situation whether it is possible to find ways of helping men with reduced fertility by studying the genes of men with prostate cancer.


'/>"/>
Contact: Yvonne Lundberg
Yvonne.Giwercman@med.lu.se
46-705-977-904
Lund University
Source:Eurekalert

Related medicine news :

1. Science Shows How Exercise Might Help in Prostate Cancer
2. Study Compares 3 Common Prostate Cancer Treatments
3. Experimental Drugs Do Battle Against Advanced Prostate Cancer
4. Research from the 2012 Genitourinary Cancers Symposium highlights new treatments, compares existing therapies for prostate cancer
5. New Queens University research sheds light on gene destruction linked to aggressive prostate cancer
6. Brachytherapy reduced death rates in high-risk prostate cancer patients, study finds
7. Prostate cancer screening and treatment decisions must act on evidence, not beliefs
8. Drug May Slow Early Prostate Cancer: Study
9. Preoperative MRI may reduce risk of nerve damage in prostate cancer surgeries
10. Prostate cancer study proves drug delays disease progression
11. Eating smart: Researcher studies foods, dietary supplements that may reduce risk of prostate cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/24/2017)... ... May 24, 2017 , ... Dr. Alan I. Benvenisty, ... in New York City. He is known for his distinguished expertise and experience in ... Dr. Benvenisty holds sub-specialty training in treating renovascular disease and aortic aneurysm . ...
(Date:5/24/2017)... ... May 24, 2017 , ... ... in Bayside, NY, who have now spent 10 years as clinical instructors for ... University (NYU) College of Dentistry. Through the program, private practitioners receive cutting-edge clinical ...
(Date:5/24/2017)... ... May 24, 2017 , ... STATEMENT OPPOSING PRESIDENT ... opposed to Donald Trump’s budget, “A New Foundation for American Greatness—President's Budget FY ... the poor, marginalizes underserved populations, undermines productivity, and destroys the social safety net ...
(Date:5/24/2017)... ... May 24, 2017 , ... ... female reproductive tract in which the endometrial lining of the uterus spreads ... and pain. Patients experiencing painful intercourse, painful periods, pelvic pain, or irregular ...
(Date:5/24/2017)... California (PRWEB) , ... May 24, 2017 , ... If you are thinking of a ... are interested in business architecture, October is the perfect time to visit. , Business Architecture ... an à la carte offering for individuals, as a 4-½ day package for individuals, and ...
Breaking Medicine News(10 mins):
(Date:5/9/2017)... , May 9, 2017 Zimmer Biomet Holdings, ... musculoskeletal healthcare, today announced it has earned a spot ... 2017" list. The Company was ranked among 500 U.S. ... Employers and Healthcare Equipment and Services. The ... on an anonymous, independent survey of over 30,000 employees ...
(Date:5/8/2017)... 2017 MACRA replaces the outdated sustainable ... service reimbursement. Black Book Research crowdsource-surveyed 8,845 physician practices ... The Market for MIPS Compliance Technology is Booming ... with 3 or more clinicians seek to buy Merit-Based ... the magnitude of the changes, the hunt is on ...
(Date:5/6/2017)... N.Y. , May 5, 2017  Hill-Rom Holdings, ... will add approximately 100,000 square feet to its Welch ... September 2016 its commitment to bring more than 100 ... , where Welch Allyn has maintained a significant presence ... help accommodate these new positions, a large portion of ...
Breaking Medicine Technology: