Navigation Links
Prostate cancer prognosis hope
Date:10/30/2012

Scientists have discovered a molecular 'tell' in laboratory experiments that could help doctors determine the severity of a patient's prostate cancer.

Cancer of the prostate the most common male cancer in the UK presents in two distinct ways: a low-risk type, which may never cause any symptoms, and a high-risk form that needs treatment to prevent it spreading to other parts of the body.

Knowing which type of prostate cancer each patient has some 40,000 British men per year is therefore essential to ensuring they receive the correct treatment.

Lead researcher Dr Angeliki Malliri, from the University of Manchester's Paterson Institute for Cancer Research, said: "Prognosis tells, or biomarkers, give doctors an indication of how a patient will fare after treatment. In prostate cancer, biomarkers that help differentiate between the low-risk and high-risk types of cancer are crucial to decide if and what type of treatment a patient needs."

The study, funded by Cancer Research UK and published in the journal Nature Cell Biology, identified the protein β2-syntrophin as a new prognosis marker for prostate cancer. The team, part of the Manchester Cancer Research Centre (MCRC), discovered that the protein is involved in establishing tight connections between cells, which are crucial for holding them together to maintain tissue structure and prevent tumours from spreading.

Co-author Dr Natalie Mack said: "We showed that when β2-syntrophin is lost from these cell-to-cell connections, the cells become disorganised and this is what happens in cells from prostate cancer samples, potentially helping them to spread.

"Our findings indicate that the loss of β2-syntrophin at cell-to-cell connections in the prostate is an indicator of prostate cancer progression and patients with reduced levels of this protein at these cell-to-cell connections are more likely to have a recurrence of their cancer after tr
'/>"/>

Contact: Aeron Haworth
aeron.haworth@manchester.ac.uk
44-161-275-8383
University of Manchester
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Proton therapy treatment preserves quality of life for men with prostate cancer
2. For many prostate cancer patients, Web sites are too difficult to read
3. Viagra Can Help Prostate Cancer Patients Maintain Sex Lives: Study
4. Drop in testosterone tied to prostate cancer recurrence
5. Moffitt Researchers find genetic predictors of fatigue for some prostate cancer patients
6. First web-based prostate cancer database launches
7. Lab Contamination Behind Debunked Link Between Virus, Prostate Cancer
8. Researchers reveal underlying mechanism of powerful chemotherapy for prostate cancer treatment
9. Cloned receptor paves way for new breast and prostate cancer treatment
10. Drug Used to Prevent Prostate Cancer Wont Lower Quality of Life
11. Taking Breaks From Prostate Cancer Hormone Therapy Seems Safe: Study
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... , ... July 31, 2015 , ... Ticket Down is a reputable source of authentic ... National Soccer Team will face the Australia Women's National Team in conjunction with their Victory ... of 5-2. Carli Lloyd from the USA team was awarded the Golden Ball as ...
(Date:7/31/2015)... ... July 31, 2015 , ... According to WFLA on ... of heroin use and eventual overdoses. Thricefold deaths have held steady over the last ... on the Sarasota heroin epidemic, which was spurred by the crackdown of prescription painkillers. ...
(Date:7/31/2015)... , ... July 31, 2015 , ... Physical therapy for knee osteoarthritis ... patient's quality of life. It keeps the patient from doing what they want or need ... have a hard time using the stairs. The patient's exercise regime may be limited by ...
(Date:7/31/2015)... ... 31, 2015 , ... A family-run business in Grand Rapids, ... sourced all over the world, then manufactured into specific formulations in northern Michigan. ... highest-quality oils in the industry, which we are bringing to consumers at prices ...
(Date:7/31/2015)... ... July 31, 2015 , ... “ Crack’em ” was featured on NewsWatch as ... available to consumers. Amanda Forstrom, a technology expert and special reporter for NewsWatch, conducted ... while cooking. , Cooking can be a very messy experience, especially when cracking eggs. ...
Breaking Medicine News(10 mins):Health News:Cheap USA vs. Australia Tickets at Ford Field in Detroit, MI: Ticket Down Slashes Ticket Prices for Australia vs. USWNT International Friendly Match at Ford Field 2Health News:Sarasota Sufferers Increased Heroin Overdoses and Deaths 2Health News:Sarasota Sufferers Increased Heroin Overdoses and Deaths 3Health News:NYDNRehab Is the First Clinic in NYC to Provide APOS Therapy Based on Results of Complete Gait Analysis 2Health News:NYDNRehab Is the First Clinic in NYC to Provide APOS Therapy Based on Results of Complete Gait Analysis 3Health News:Living Pure Essential Oils takes Therepeutic Essential Oil Market by Storm 2Health News:Make Less Mess while Cooking with Crack’em 2
... Forest University Baptist Medical Center in North Carolina found that ... transplants of kidneys// earlier rejected for having limited function. They ... which one can solve the problem of organ donor shortage. ... is to prove that it is better or similar to ...
... The high acid content in popular drinks could just be ... suggests a new study// conducted by researchers at University of ... Bull or Gatorade ate into the enamel surface, over the ... agreement that the high acidic levels of the popular beverages ...
... deteriorate as they progress through puberty, reveals a new ... levels of insulin, however, remain unchanged in their Caucasian ... plays a crucial role in determining the individual risk ... study was conducted by Dr. Geoff Ball and his ...
... Sophos's global network of virus, spyware and spam analysis centers, have ... spreading across the internet.// ,This letter claims that lipstick ... lipstick contain a dangerously high level of lead which can cause ... email claims are not true. ,Sopho has asked the ...
... especially the pregnant women about the risks of taking ... serotonin re-uptake inhibitors //(SSRIs) affect the fetus. Drugs like ... pulmonary hypertension in babies born to women who took ... study links SSRIs to this fatal condition among babies. ...
... Ethiopian villages for two years found that a single dose ... which happens to be the// primary cause of blindness. ... to show that a single distribution exercise of one antibiotic ... has suggested that the infection relapses after two years. ...
Cached Medicine News:Health News:Tooth Enamel Eaten Away By Popular Drinks 2Health News:African American Children More Pone to Develop Diabetes 2
(Date:7/30/2015)... 30, 2015 IRIDEX Corporation (NASDAQ: IRIX ... quarter 2015 financial results after the market closes on ... the release, the Company will host a conference call ... Time on Thursday, August 6, 2015 ... business developments. Interested parties may access the ...
(Date:7/30/2015)... , July 30, 2015  Today we bring you a special edition of #MedicareMonday ... remind you about some of our Medicare resources and continue highlighting the success of ... Check out our latest infographics and videos here: ... ... ...
(Date:7/30/2015)... PLAINFIELD, N.J., July 30, 2015 PTC Therapeutics, ... update and reported financial results for the second quarter ... progressing on many fronts across the organization.  We are ... Duchenne muscular dystrophy clinical trial ever conducted with topline ... Peltz, Ph.D., Chief Executive Officer, PTC Therapeutics, Inc. "Translarna ...
Breaking Medicine Technology:IRIDEX Announces Second Quarter 2015 Conference Call and Release Date 2Happy 50th Anniversary Medicare! 2Happy 50th Anniversary Medicare! 3PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 2PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 3PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 4PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 5PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 6PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 7PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 8PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 9PTC Therapeutics Reports Second Quarter 2015 Financial Results and Provides Corporate Update 10
... ResMed Inc. (NYSE: RMD ) announced today that it will be ... ... 4, 2010 ; Jefferies Global Life Sciences Conference at the Grand Hyatt in ... Conference at the Four Seasons in Chicago on June 16, 2010 ; ...
... April 27 AstraZeneca LP and AstraZeneca ... resolve allegations that AstraZeneca illegally marketed the anti-psychotic drug ... by the Food and Drug Administration (FDA), the Departments ... Fraud Enforcement Action Team (HEAT) announced today.  Such unapproved ...
Cached Medicine Technology:ResMed Inc. to Present at Upcoming Conferences 2Pharmaceutical Giant AstraZeneca to Pay $520 Million for Off-Label Drug Marketing 2Pharmaceutical Giant AstraZeneca to Pay $520 Million for Off-Label Drug Marketing 3Pharmaceutical Giant AstraZeneca to Pay $520 Million for Off-Label Drug Marketing 4Pharmaceutical Giant AstraZeneca to Pay $520 Million for Off-Label Drug Marketing 5Pharmaceutical Giant AstraZeneca to Pay $520 Million for Off-Label Drug Marketing 6
... precision, ergonomics, and value!, Comfortable ... soft non-slip, contoured handle , Finer ... plunger spring action , Completely autoclavable ... the need for recalibration , Easy-to-read ...
This CLS number is a new product number, created to easily match Cornings product number. If showing no availability yet, please order under the old Sigma-Aldrich number (Z71,408-9) or contact custom...
... Pipettor is the #1 Pipettor for ... comfort, and reliability. Continuously adjustable. Features ... sub-micrometer. Easy interchangeable ejector buttons to ... Adjustable rapid pipet tip ejector with ...
... improved ergonomics for today's exacting laboratory ... finger rest and the large display ... Finnpipette Digitals also feature soft-touch tip ... pend.) and super blow-out for 0.2 ...
Medicine Products: