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Prostate cancer gets around hormone therapy by activating a survival cell signaling pathway
Date:6/14/2011

dy was modeled in a mouse model created by the Wu laboratory in which PTEN and AR are absent in the epithelium. The findings were replicated using samples from cancerous prostates removed from patients, work done in collaboration with researchers at UCLA and the Specialized Program of Research Excellence (SPORE) in prostate cancer.

"We found similar result in both cases," Wu said. "The human cancers may behave the same way as the mouse models."

There are new generations of AR inhibitors that are potentially more effective than their predecessors being tested now in clinical trials. There also are drugs being tested that inhibit the PI3K pathway, which is commonly activated in a variety of cancers. Clinical trials currently are being designed at UCLA that will combine these types of drugs to cut off both the primary path and escape routes that prostate cancers use to survive.


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Contact: Kim Irwin
kirwin@mednet.ucla.edu
310-206-2805
University of California - Los Angeles Health Sciences
Source:Eurekalert

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