Navigation Links
Prostate cancer drug reduces testosterone levels in as little as 3 days
Date:12/3/2008

More than 95 per cent of men who took degarelix for prostate cancer saw their testosterone levels fall dramatically as early as three days after they started treatment, according to a paper in the December issue of BJU International.

They also experienced much greater falls in their prostate-specific antigen (PSA) levels at 14 and 28 days than men taking leuprolide.

Researchers from Canada, the USA, France, Denmark and the Netherlands studied 610 men as part of the Phase Three trial, randomly assigning them to one of three study groups.

"Androgen deprivation hormone therapy is an effective response to prostate cancer, but the drugs that are most widely used cause an initial rise in testosterone - the hormone we are trying to reduce - when the patient first takes them" explains lead author Dr Laurence Klotz from the Division of Urology at the University of Toronto, Canada.

"We prefer to avoid this biochemical surge as it can stimulate the prostate cancer cells and exacerbate a number of clinical symptoms, such as spinal cord compression and bone pain. It could also result in more rapid growth of microscopic disease that is present in the patient but is too small to be detected.

"Degarelix is a new gonadotrophin-releasing hormone (GnRH) antagonist. It works by binding to, and blocking, the GnRH receptors in the pituitary gland, reducing the amount of LH and FSH hormones that are released. This leads directly to a rapid fall in testosterone."

Group one (207 patients) received an injection of 240mg of degarelix in month one, followed by a maintenance dose of 80mg every month for eleven months and group two (202 patients) received 240mg of degarelix in month one followed by a maintenance dose of 160mg for eleven months.

The third group (201 patients) received a monthly 7.5mg dose of leuprolide, which is a GnRH agonist.

At the start of the trial the study participants had a med
'/>"/>

Contact: Annette Whibley
wizard.media@virgin.net
Wiley-Blackwell
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
2. First biomarker discovered that predicts prostate cancer outcome
3. Frequent Prostate Screens Fail to Improve Aggressive Cancer Diagnoses
4. New male sling procedure helps prostate cancer survivors who suffer from urinary incontinence
5. Us TOO Launches National SEA Blue Campaign for Prostate Cancer Awareness Month
6. Red wine compound shown to prevent prostate cancer
7. Barbershop Talks Cut Black Mens Prostate Cancer Risk
8. Generic prostate drug helps find high-risk cancers early
9. Finasteride unlikely to induce high grade prostate cancers
10. Shrinkage of prostate led to overestimation of cancer risk in trial
11. Prostate Cancer Awareness Week to Screen Thousands
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/22/2014)... 2014 7,178 small business owners and ... Friday shopping and opted instead to join Digital Marketer, ... for their 5th annual “Black Friday Boot Camp”. ... to attend the 5 hour online training event and ... to support two Central Texas based charities dedicated to ...
(Date:12/22/2014)... (PRWEB) December 22, 2014 Christmas is days ... has a fast and easy solution that will please: the ... can be purchased from from $25 up to $350," says ... 100% customer satisfaction and a wide array of skin care ... fees and no expiration dates. , Gift delivery past ...
(Date:12/22/2014)... A substantial percentage of patients ... (CT) to evaluate abnormal findings on outpatient chest ... to a new study published online in the ... show that radiologist recommendations for additional imaging (RAIs) ... care. , RAIs, which have grown 200 percent ...
(Date:12/22/2014)... (PRWEB) December 22, 2014 Parker & ... absolute best in Arizona home contracting services reports a ... to its quality services in 2014. As a company ... the early 1970s, Parker and Sons is a business ... The company works side-by-side with other top quality companies ...
(Date:12/21/2014)... Weddingshe.com, an outstanding online supplier of ... released its new selection of Cocktail Dresses for the ... to the newest fashion trends. , “We ... cocktail parties . All of them are offered at ... are making every effort to offer a nice shopping ...
Breaking Medicine News(10 mins):Health News:Austin Company Digital Marketer Raises 100K to Fight Childhood Cancer 2Health News:Austin Company Digital Marketer Raises 100K to Fight Childhood Cancer 3Health News:RSNA: Radiologist Recommendations for Chest CT Have High Clinical Yield 2Health News:RSNA: Radiologist Recommendations for Chest CT Have High Clinical Yield 3Health News:Parker & Sons Reports A Record Number Of Favorable References With Regard To Its Quality Services In 2014 2Health News:Parker & Sons Reports A Record Number Of Favorable References With Regard To Its Quality Services In 2014 3Health News:Stunning Cocktail Party Dresses from Weddingshe.com 2
... at Wake Forest University School of Medicine has been awarded ... aspects of blood lipoproteins, such as cholesterol, that may be ... cause of death across the civilized world. , The ... of good nutrition and pathways of metabolism that can lead ...
... industry. , ... Nashville, TN (PRWEB) ... into the inner workings of disease management (DM) comes a ... article is published this month in The Journal of Managed ...
... Thursday, Sept 11, 2008 to Sunday, Sept 14, 2008, WHERE: Moscone South Convention ... San Francisco, CA 94103, ... 55 4th Street ... Kim Nickols (916) 704-8965, WHAT: Approximately 15,000 ...
... by other children wielding club while playing away from course, ... rare, golf-related eye injures in children can be devastating, says ... boys and five girls, average age 10.2 years, treated at ... were injured by golf clubs and one patient (9 percent) ...
... Md., Sept. 8 Spherix Incorporated,(Nasdaq: SPEX ) ... reverse stock split at a Special Meeting of Stockholders ... minimum per share market price,requirements for continued listing on ... record entitled to receive notice of, and,to vote at, ...
... consumer choices , , MONDAY, Sept. 8 (HealthDay News) -- You ... credit cards, gift cards or gift certificates, according to a ... issue of the Journal of Experimental Psychology: Applied , ... estimate expenses in detail. , "The more transparent the ...
Cached Medicine News:Health News:New Paper Reveals Reasons for Payer Discontent with Disease Management 2Health News:Renowned Dentists to Present Latest on Dental Innovations 2Health News:Renowned Dentists to Present Latest on Dental Innovations 3Health News:Kids' Eye Injuries From Golf Clubs Rare But Severe 2Health News:Spherix Incorporated to Seek Stockholder Approval of Reverse Stock Split 2Health News:Buyers Spend More With Non-Cash Purchases 2
(Date:12/19/2014)... WESTMINSTER, Colo. , Dec. 19, 2014  Monarch ... (f/k/a Cannabis Kinetics Corp.) is pleased to provide this ... for continued growth in 2015. "Over this ... corporate goals and I am extremely proud to say ... diversified position today than it has ever been," stated ...
(Date:12/19/2014)... , Dec. 18, 2014  Sage Analytics ... generation of equipment for the testing of marijuana ... of the new Luminary™ Profiler, the industry,s first ... measurement in a cost-effective, portable unit. ... specific needs of the cannabis industry, the Luminary™ ...
(Date:12/19/2014)... 18, 2014 Since last month,s FBI shutdown ... known as the leading online black market for illegal ... in its offering of drugs and other illegal items.  ... takedowns did succeed in lowering the numbers of drugs ... the markets in August. But some new sites that ...
Breaking Medicine Technology:Monarch America Inc. CEO Reviews Recent Achievements and Provides Outlook for 2015 2Monarch America Inc. CEO Reviews Recent Achievements and Provides Outlook for 2015 3Sage Analytics Develops Breakthrough System for Potency Testing of Cannabis Products 2Post Silk Road - Another Online Drug Den Now Dominates the DarkNet 2Post Silk Road - Another Online Drug Den Now Dominates the DarkNet 3
... CEL-SCI Corp. (Amex: CVM ) announces the following ... October 13, 2010 @ 11:30 AM EasternWhere: , ... Simply log on to the web at the address above.Contact: ... unable to participate during the live webcast, the call will ...
... 11 The preeminent law office of Nurenberg, ... action lawsuit against Johnson & Johnson,s artificial joint ... clients who suffered damages resulting from the company,s ... District Court, Northern District of Ohio, Eastern Division) ...
Cached Medicine Technology:DePuy Orthopaedics Accused of Deceiving Hip Replacement Patients 2DePuy Orthopaedics Accused of Deceiving Hip Replacement Patients 3
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference ... laboratory research and development. ARUP offers an ... unique medical tests in clinical and anatomic ... ARUP Laboratories' clients include more than half ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: