Navigation Links
Prostate Cancer Treatment Could Impair Men's Thinking
Date:7/29/2008

Hormone deprivation approach seems to affect memory, concentration, study finds,,

TUESDAY, July 29 (HealthDay News) -- Men undergoing hormone deprivation therapy to keep prostate cancer at bay may experience memory loss and have trouble concentrating, a new study finds.

Testosterone is thought to help spur prostate cancer. So, androgen depletion therapy has been used for many years to treat the disease. By reducing the level of testosterone, the treatment helps to slow the growth of prostate cancer cells.

However, "androgen depletion therapy can potentially have some subtle, adverse cognitive effects," said lead researcher Christian J. Nelson, from the department of psychiatry and behavioral sciences at Memorial Sloan-Kettering Cancer Center in New York City.

These effects include difficulty in remembering and multi-tasking, Nelson said. "These men might not be thinking as quickly as they used to," he said. "They may find it more difficult to hold several pieces of information in their mind at one time."

The report was published in the July 28 online edition of Cancer.

For the study, Nelson's group reviewed a variety of studies in both animals and people that looked at the effects of androgen depletion therapy on cognition. They found that, depending on the study, between 47 percent and 69 percent of men treated with a hormonal approach did experience some decline in at least one area of cognition.

Troubling as the cognitive effects might seem, men should not seek to discontinue their therapy, Nelson said. "Treating the disease is much more important than these subtle cognitive effects," he said.

It's not known whether these effects are a direct result of hormone depletion or whether they are tied to the other side effects of hormone therapy. Those side effects include hot flashes, fatigue and anemia.

The research in this area is new, and not much is known about the full extent of cognitive problems brought on by androgen depletion, Nelson said. As for specific advice, Nelson noted there is no standard recommendation, but a few common sense tips may help.

"As men start this therapy, it is important to monitor them to see if they are having any of these effects," Nelson said. "If you are having difficulty with memory, make sure you are writing things down more. If you are having difficulty with multi-tasking, try simple things like focusing on one thing at a time," he said.

It is possible that when hormone therapy is stopped, these adverse cognitive effects go away, Nelson added.

Dr. Durado Brooks, director of prostate and colorectal cancers at the American Cancer Society, said the study highlights a largely ignored side effect of androgen depletion therapy.

Recent studies have also shown an increased risk of fracture and other conditions associated with the treatment, he said.

"There is a study that suggests that cardiovascular death rates may be higher among men undergoing this therapy. There is clear evidence that there is an increase in metabolic syndrome, which is associated with coronary artery disease and diabetes," Brooks said.

Moreover, androgen depletion therapy continues to be offered in situations where its benefits are not clear, Brooke said. Androgen depletion therapy may not be appropriate for treating early disease and should only be used in cases of advanced prostate cancer, he said.

"Many men are being treated with androgen depletion therapy for localized disease," Brooks said. "A study that was published just last month shows there is no survival advantage for most men in that situation," he said. "Men need to decide whether the potential benefit outweighs the harm of the therapy for them."

More information

For more about cancer, visit the American Cancer Society.



SOURCES: Christian J. Nelson, Ph.D., department of psychiatry and behavioral sciences, Memorial Sloan-Kettering Cancer Center, New York City; Durado Brooks, M.D., director, prostate and colorectal cancers, American Cancer Society, Atlanta; July 28, 2008, Cancer


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. Conventional prognostic factors fail to explain better prostate cancer survival in most Asian men
2. First biomarker discovered that predicts prostate cancer outcome
3. Frequent Prostate Screens Fail to Improve Aggressive Cancer Diagnoses
4. New male sling procedure helps prostate cancer survivors who suffer from urinary incontinence
5. Us TOO Launches National SEA Blue Campaign for Prostate Cancer Awareness Month
6. Red wine compound shown to prevent prostate cancer
7. Barbershop Talks Cut Black Mens Prostate Cancer Risk
8. Generic prostate drug helps find high-risk cancers early
9. Finasteride unlikely to induce high grade prostate cancers
10. Shrinkage of prostate led to overestimation of cancer risk in trial
11. Prostate Cancer Awareness Week to Screen Thousands
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Prostate Cancer Treatment Could Impair Men's Thinking
(Date:5/5/2016)... , ... May 05, 2016 , ... ... Drago presented a talk highlighting the organization’s successful Care Transitions program ... , The talk was titled “Minimizing Costs in the Post-Acute Environment Through Effective ...
(Date:5/5/2016)... CA (PRWEB) , ... May 05, 2016 , ... The ... the Year, Derek Pittman, along with his university coaching staff. Together they bring their ... with separate sessions run for youth players ages 5-13, and high school players. Session ...
(Date:5/5/2016)... (NEW YORK, New York) , ... (PRWEB) May 05, 2016 , ... ... partnership with healthcare talent acquisition startup, HireNurses, on the eve of National Nurses ... for job seeking nurses and healthcare employers. With their enrollment into the Talent Tech ...
(Date:5/5/2016)... ... 05, 2016 , ... United Collection Bureau, Inc. (UCB) announces Sarah Clark as ... years of experience within the healthcare revenue cycle industry. With a primary focus of ... Patient Financial Services at Spectrum Health. While at Spectrum Health, Clark helped Spectrum achieve ...
(Date:5/5/2016)... ... ... Institute will celebrate its three-year anniversary on May 14 by giving away a free ... May. To date, the Lung Institute has treated over 2,000 people at their five clinics ... the success of this treatment and to the patients who refuse to give up,” says ...
Breaking Medicine News(10 mins):
(Date:5/4/2016)... Yissum Research Development Company ... that it had signed an exclusive world-wide licensing and ... novel protein degradation and immunomodulatory drugs for cancer and ... candidates representing first-in-class therapy for hematologic and solid malignancies. ... The novel technology was developed by Yinon ...
(Date:5/4/2016)... , May 4, 2016 ... of the  "Global Acute Ischemic Stroke Market ... to their offering.       (Logo: ... Global Acute Ischemic Stroke Market and Competitive ... Acute Ischemic Stroke pipeline products, Acute Ischemic ...
(Date:5/3/2016)... Global Insulin Needles Industry ... key companies and supported with 272 tables and ... on the current state of the Insulin Needles ... including definitions, classifications, applications and industry chain structure. ... the international market including development history, competitive landscape ...
Breaking Medicine Technology: