Navigation Links
Prostate Cancer Patients at Higher Risk of Blood Clots
Date:4/14/2010

Dangers were greatest for those on hormone therapy, study found

WEDNESDAY, April 14 (HealthDay News) -- Men with prostate cancer are at greater risk for developing blood clots, especially if they're undergoing hormone therapy, new research shows.

"Our findings indicate that it is important to consider thromboembolic [blood-clotting] side effects when treating patients with prostate cancer, especially those who require endocrine treatment," said Mieke van Hemelrijck, lead author of a study in the April 13 online issue of The Lancet Oncology.

Still, the findings shouldn't change the way men with this type of tumor are treated, just perhaps the way they are monitored, van Hemelrijck added.

"Endocrine treatment is currently the cornerstone of therapy for men with locally advanced or metastatic disease. It is thus not possible to change the treatment, but doctors can be more aware of the risk of thromboembolic diseases and check for certain symptoms when following up their patients," said van Hemelrijck, who is a doctoral candidate at Kings College London.

And the findings do give an extra round of reassurance that this is indeed a risk, another expert noted.

"We have known for decades that cancer patients have a greater risk of blood clots, [but] it hasn't been as well-defined in the prostate cancer population," said Dr. Steven Clinton, director of prostate and genitourinary oncology at The Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute in Columbus. "For the first time, this puts some numbers on the risk in that population. It's an enormous study, and it does give us some numbers to work with."

According to background information in the study, cancer patients in general have about a fourfold greater risk of developing blood clots than people who are cancer-free.

Advancing age and other treatments for cancer, including prostatectomy or removal of the prostate gland, might further elevate that clotting risk.

These authors analyzed data from Sweden's National Prostate Cancer Register, which includes 96 percent of all prostate cancer cases in that country. Men were divided into three groups: those receiving endocrine or hormone therapy to reduce levels of male hormones (including testosterone), those receiving surgery and/or radiation and those who were simply being watched.

Men taking hormone therapy had a 2.48 increased risk of developing a blood clot and almost double the chance of a pulmonary embolism (when the clot travels to the lung), compared to men without prostate cancer.

Those in the prostatectomy group had a 73 percent increased risk of blood clots and double the risk of a pulmonary embolism. Those in the "watch-and-wait group had a 27 percent increased risk of blood clots and a 57 percent increased risk of that clot moving to the lung.

None of the groups saw an increased risk of arterial embolism, when clots block an artery.

Those under the age of 65 and those with more advanced disease had even more risk. Given that men in the no-treatment-yet group also had more blood clots, much of the risk was likely from the cancer itself.

"This is probably telling us that something about the cancer and its biology may be impacting coagulation," Clinton said.

However, the type of treatment obviously also plays a role.

Still, the absolute number of blood clots seen in the study was relatively low -- about four per 1,000 person-years, up from 2.

"One should be aware of [the increased risk] and make sure that that the patient is being monitoring for symptoms of blood clots but you're not going to go so far as to recommend that we give [blood thinners] to everybody to prevent it," Clinton said.

More information

The National Cancer Institute has more on prostate cancer.



SOURCES: Mieke Van Hemelrijck, doctoral candidate, Kings College London; Steven Clinton, M.D., Ph.D., director, prostate and genitourinary oncology, Ohio State University Comprehensive Cancer Center - James Cancer Hospital and Solove Research Institute, Columbus; April 13, 2010, The Lancet Oncology


'/>"/>
Copyright©2010 ScoutNews,LLC.
All rights reserved

Related medicine news :

1. Registration Now Open for Little Red Door's Unite 2 Fight Race Against Prostate Cancer Saturday, July 10, 2010
2. New investigation supports correlation between XMRV and prostate cancer
3. Drug reduces risk of prostate cancer diagnosis in high-risk men
4. Study Revives Debate on Prostate Drug
5. Prostate Cancer Treatment Database Hits Milestone of 12,500
6. Male Infertility Significantly Increases Risk of Prostate Cancer
7. Infertility Raises Risk of More Aggressive Prostate Cancer
8. Infertility increases a mans risk of prostate cancer
9. Prostate Cancer Radiation Side Effects May Subside With Time
10. Increased radiation dose does not increase long-term side effects for prostate cancer patients
11. Freezing Tumors Shows Promise Against Prostate, Breast Cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2017)... ... ... past six years, Lightning Labels has sent out a call for users of its custom ... creativity of their designs. Submissions this year were open from May 18 to July 1 ... winners of the sixth annual Photo Contest, along with the prizes they've received:, ...
(Date:8/22/2017)... ... August 22, 2017 , ... “Wilderness Voices”: a collection ... travel. “Wilderness Voices” is the creation of published author, Martha McKown, an ordained ... was inspired as a very young child when her older sisters studied High School ...
(Date:8/22/2017)... ... , ... TopConsumerReviews.com recently gave a best-in-class 5-star rating to Energy NADH, a ... of modern life continually makes more demands on time and energy, people are finding ... people in vicious high/low cycles and can also cause long term health issues. More ...
(Date:8/21/2017)... ... August 22, 2017 , ... ... I. Stevens as a 2017-2018 inductee into its VIP Woman of the ... NAPW is the nation’s leading networking organization exclusively for professional women, boasting more ...
(Date:8/21/2017)... ... 2017 , ... Marathon running has surged in popularity in ... running increases exposure to ultraviolet radiation, a carcinogen that promotes skin cancer. Studies ... half may be adequately protecting themselves with proper clothing and sunscreen. , ...
Breaking Medicine News(10 mins):
(Date:8/2/2017)... , Aug. 2, 2017 ... Who,s Who as a Pinnacle Lifetime Professional in ... Key Account Manager at Turing Pharmaceuticals, AG. Her ... troubleshooting and relationship building.                ... more than 25 years of experience as a ...
(Date:7/31/2017)... Pharmacy, Inc. (NYSE: DPLO), has been named one of the ... Crain,s Detroit Business . The annual Crain,s Fast ... growth. This year,s edition measures growth from 2013 to 2016. ... list, visit crainsdetroit.com/awards/fast_50/2017 .  "Being named ... Phil Hagerman , CEO and chairman of Diplomat. "We,ve made ...
(Date:7/27/2017)... 2017  Zimmer Biomet Holdings, Inc. (NYSE and SIX: ZBH) ... 30, 2017.  The Company reported second quarter net sales ... prior year period, and an increase of 2.1% on ... of contribution from the LDR Holding Corporation acquisition, second ... of 2016, or 0.3% on a constant currency basis. ...
Breaking Medicine Technology: