Navigation Links
Prostaglandin receptor key to atherosclerosis development
Date:12/15/2008

The researchers found that the mice with macrophages lacking the EP4 receptor had a significant reduction in atherosclerosis compared to mice with the EP4 receptor. They also observed an increase in macrophage programmed cell death (apoptosis) in the atherosclerotic lesions of mice with EP4-deficient cells.

The team examined EP4 receptor signaling pathways and discovered that two pathways known to be involved in macrophage cell survival (PI3K/Akt and NF-kappaB pathways) had lower activity in the EP4-deficient mice, suggesting a mechanism for the increase in macrophage cell death.

"Our studies clearly show that prostaglandin-E2 plays an important role in atherosclerosis and in macrophage survival," Linton said. "Prostacyclin and thromboxane aren't the whole story."

The findings suggest the potential for modulating the development of atherosclerosis with inhibitors of prostaglandin-E2 synthesis, which are already being studied, and also by manipulating the EP receptors or their signaling pathways, Linton said.

The link between macrophage apoptosis and lesion development remains unclear, he said.

There have been some reports that increased macrophage apoptosis in early lesions reduces the lesion area, Linton said. Other studies have suggested that macrophage apoptosis creates a pro-inflammatory environment that promotes the development of more complex lesions. Still other reports speculate that macrophage cell death promotes plaque rupture, causing heart attacks and strokes.

If the latter is true, Linton said, the current studies could offer a mechanistic explanation for how the drug Vioxx increased heart attacks in patients. Vioxx, a selective inhibitor of the enzyme cyclooxygenase-2 (COX-2), was withdrawn from the market because of concern about an apparent increase in cardiovascular risk.

The current findings suggest that because COX-2 inhibition would reduce prostaglandin-E2 levels (COX enzymes perfor
'/>"/>

Contact: Kathy Whitney
kathy.f.whitney@vanderbilt.edu
615-322-4747
Vanderbilt University Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. NicOx Announces U.S. Phase 2a Results for PF-03187207 and Gives an Update on Continuing NO-prostaglandin Program
2. Investigational Agent Targeting Metabotropic Glutamate 2/3 Receptors Demonstrates Antipsychotic Activity in Humans, Study in Nature Medicine Finds
3. Low level of neuronal receptor linked to mild cognitive impairment and Alzheimers disease
4. Pathway Diagnostics Announces Commercial Availability of SensiTrop(TM) HIV Co-receptor Tropism Assay
5. Pharmacopeia Acquires Selective Androgen Receptor Modulator (SARM) Program from Bristol-Myers Squibb
6. Food restriction increases dopamine receptor levels in obese rats
7. Quest Diagnostics Licenses Technology Underlying SensiTrop(TM) HIV Co-Receptor Tropism Test from Pathway Diagnostics
8. Abbott Researchers Target Neuronal Nicotinic Receptors for Treatment of Pain and Cognition
9. Exelixis to Receive Milestone Payment From Bristol-Myers Squibb for Achievement of Liver X Receptor Agonist Development Milestone
10. Receptor protein appears to be key in breakdown of kidney filtration
11. Cell-death receptor links cancer susceptibility and inflammation
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/17/2014)... Cut Pro X plugin developers have announced a new anamorphic ... “ProBlue 5k is a compilation of anamorphic flares that can ... Austin, CEO of Pixel Film Studios. “Blurring the line between ... , ProBlue 5k is the ultimate Ultra High Definition anamorphic ... compilation of over 100 anamorphic flares can be applied to ...
(Date:9/17/2014)... who struggle to distinguish between a business strategy and business ... the answer by reading Per Wickstrom’s latest blog post. , ... plan and a business strategy are both strategic – and ... I view it is that a business plan is part ... , According to the blog post, a business plan ...
(Date:9/17/2014)... 17, 2014 The Oliver Law Group ... allegedly caused by Non-Sterile Other-Sonic Ultrasound Transmission Gel ... their options for legal recourse. Other-Sonic ultrasound gel was ... in March 2012, after the product was linked to ... Beaumont Hospital in Royal Oak, Michigan . While victims ...
(Date:9/17/2014)... HealthDay Reporter WEDNESDAY, ... womb to household chemicals known as phthalates might increase ... researchers reported in a new study. Children had ... between age 5 and 11 if their mothers were ... (pronounced thal-ates), the researchers found. The two phthalates were ...
(Date:9/17/2014)... FRISCO, Texas (PRWEB) September 17, 2014 ... (EV-D68) outbreak that is hospitalizing scores of infants, children ... Louisiana, says Dr. Kirk Mahon, medical director of Legacy ... , “There have been no reported cases of EV-D68 ... Oklahoma and Louisiana, that could change,” he said. “Implementing ...
Breaking Medicine News(10 mins):Health News:A New Plugin Entitled ProBlue 5k Was Released Today from Pixel Film Studios Exclusively for Final Cut Pro X 2Health News:Per Wickstrom’s Latest Blog Explores the Difference Between a Business Plan and a Business Strategy 2Health News:Victims of Pseudomonas Infections Allegedly Caused by Other-Sonic Ultrasound Transmission Gel Face Statute of Limitations, Reports The Oliver Law Group P.C. 2Health News:Victims of Pseudomonas Infections Allegedly Caused by Other-Sonic Ultrasound Transmission Gel Face Statute of Limitations, Reports The Oliver Law Group P.C. 3Health News:Victims of Pseudomonas Infections Allegedly Caused by Other-Sonic Ultrasound Transmission Gel Face Statute of Limitations, Reports The Oliver Law Group P.C. 4Health News:Prenatal Exposure to Chemicals in Plastics Linked to Asthma Risk in Kids 2Health News:Prenatal Exposure to Chemicals in Plastics Linked to Asthma Risk in Kids 3Health News:Prenatal Exposure to Chemicals in Plastics Linked to Asthma Risk in Kids 4Health News:Legacy ER & Urgent Care Warns North Texans about Dangers of Enterovirus D68 2
... , , , , , NEW YORK, ... of a letter of intent for a strategic alliance with Rusan ... Rusan providing Rx for Africa Inc. the tuberculosis (TB) drug, "RUCOX-4" ... World Health Organization (WHO), which is also approved by the Ethiopian ...
... ,Performance Excellence and Accountability in Kidney Care, to reduce mortality ... 2012 - , , WASHINGTON, June 8 ... quality improvement campaign pledging to reduce mortality among first-year dialysis ... percent by the end of 2012. , ...
... Hispanics - the "invisible" Boomers - Face Workplace Challenges , ... play a dynamic role in helping solve long-term challenges for many ... according to a new AARP report, being released today at AARP,s ... http://www.newscom.com/cgi-bin/prnh/20070209/NYF043LOGO ) , , ...
... , Aspirin a Day, Other Services Cited , in ... 8 As Congress tackles health reform, a new public education ... year by investing in five basic preventive services. That includes 45,000 ... benefit were advised by their doctors to take a daily dose ...
... PHOENIX, June 8 Summer can be a fun time of year, ... Plan Arizona encourages area seniors to take extra precautions this season with ... Prevent sunburn. Applying sunscreen ... prior to going out, everyday. Reapply every two to four hours, more ...
... and Rochester , N.Y. ... New Reports from HealthLeaders-InterStudy , , NASHVILLE, Tenn., ... market intelligence, reports that medical home pilot initiatives across the ... such programs can save money by directing care more efficiently. ...
Cached Medicine News:Health News:Rx for Africa, Inc. Signs Letter of Intent for Strategic Alliance with Rusan Pharma, Ltd. of India 2Health News:Rx for Africa, Inc. Signs Letter of Intent for Strategic Alliance with Rusan Pharma, Ltd. of India 3Health News:Kidney Care Partners Launches Health Care Campaign to Improve Survival Rates of First-Year Dialysis Patients 2Health News:Kidney Care Partners Launches Health Care Campaign to Improve Survival Rates of First-Year Dialysis Patients 3Health News:Hispanic Workers Ages 50+ May Help Employers Solve Potential Future Labor Shortages 2Health News:Hispanic Workers Ages 50+ May Help Employers Solve Potential Future Labor Shortages 3Health News:U.S. Could Save 100,000 Lives a Year with Five Basic Preventive Services 2Health News:SCAN Health Plan Arizona Encourages Sun Smarts and Plenty of Water for Seniors This Summer 2Health News:Medical Home Pilot Initiatives Continue to Expand Nationwide 2Health News:Medical Home Pilot Initiatives Continue to Expand Nationwide 3
(Date:9/17/2014)... 2014  Aratana Therapeutics, Inc. (NASDAQ: ... licensing, developing and commercializing innovative biopharmaceutical products for ... public offering of 4,500,000 shares of its common stock at ... share. Aratana has granted the underwriters a 30-day ... shares of its common stock. Jefferies ...
(Date:9/17/2014)... Calif. , Sept. 17, 2014 ... announced that it has earned a $4 million ... AKAO ) associated with the initiation of a ... serious multi-drug resistant (MDR), gram-negative bacterial infections.  The ... study to evaluate the efficacy and safety of ...
(Date:9/17/2014)... MILL VALLEY, Calif. , Sept. 17, ... announced a partnership in the fight against sarcoma. ... Sarcoma Alliance Suzanne Renee Leider Memorial Assistance Fund. ... assistance to reimburse sarcoma patients for expenses directly ... sarcoma specialist. Scientific literature reinforces the importance of ...
Breaking Medicine Technology:Aratana Therapeutics, Inc. Announces Pricing of Public Offering 2Isis Pharmaceuticals Earns $4 Million from Achaogen for the Initiation of a Phase 3 Study of Plazomicin 2Isis Pharmaceuticals Earns $4 Million from Achaogen for the Initiation of a Phase 3 Study of Plazomicin 3Champions Oncology Partners with Sarcoma Alliance to Bring Personalized Treatment Options to Sarcoma Patients 2Champions Oncology Partners with Sarcoma Alliance to Bring Personalized Treatment Options to Sarcoma Patients 3
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: