Navigation Links
Proposed drug may reverse Huntington's disease symptoms
Date:6/20/2012

With a single drug treatment, researchers at the Ludwig Institute for Cancer Research at the University of California, San Diego School of Medicine can silence the mutated gene responsible for Huntington's disease, slowing and partially reversing progression of the fatal neurodegenerative disorder in animal models.

The findings are published in the June 21, 2012 online issue of the journal Neuron.

Researchers suggest the drug therapy, tested in mouse and non-human primate models, could produce sustained motor and neurological benefits in human adults with moderate and severe forms of the disorder. Currently, there is no effective treatment.

Huntington's disease afflicts approximately 30,000 Americans, whose symptoms include uncontrolled movements and progressive cognitive and psychiatric problems. The disease is caused by the mutation of a single gene, which results in the production and accumulation of toxic proteins throughout the brain.

Don W. Cleveland, PhD, professor and chair of the UC San Diego Department of Cellular and Molecular Medicine and head of the Laboratory of Cell Biology at the Ludwig Institute for Cancer Research, and colleagues infused mouse and primate models of Huntington's disease with one-time injections of an identified DNA drug based on antisense oligonucleotides (ASOs). These ASOs selectively bind to and destroy the mutant gene's molecular instructions for making the toxic huntingtin protein.

The singular treatment produced rapid results. Treated animals began moving better within one month and achieved normal motor function within two. More remarkably, the benefits persisted, lasting nine months, well after the drug had disappeared and production of the toxic proteins had resumed.

"For diseases like Huntington's, where a mutant protein product is tolerated for decades prior to disease onset, these findings open up the provocative possibility that transient treatment
'/>"/>

Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Proposed testosterone testing of some female olympians challenged by Stanford scientists
2. Treatment of childhood OSA reverses brain abnormalities
3. Combination of 2 drugs reverses liver tumors
4. In Mice, Drug Reverses Symptoms of Condition Linked to Autism
5. Kidney Disease May Be as Harmful to Heart as Heart Attack: Study
6. New Treatments Emerging from Immune and Inflammatory Disease R&D Pipelines
7. Gum Disease, HPV May Play Role in Head & Neck Cancers
8. Device implanted in brain has therapeutic potential for Huntingtons disease
9. Control gene for conveyor belt cells could help improve oral vaccines, treat intestinal disease
10. Fruit flies reveal mechanism behind ALS-like disease
11. 1960s-era anti-cancer drug points to treatments for Lou Gehrigs disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Proposed drug may reverse Huntington's disease symptoms
(Date:9/20/2014)... 2014 QueenBeeTickets.com is ready to offer ... performances. She will visit many cities in North America ... 16th of April. , Click Here to ... at QueenBeeTickets.com. , The star’s fans are not going ... favorite young singer in a live performance. Ariana Grande ...
(Date:9/20/2014)... The Arizona Advanced Manufacturing Institute (AzAMI) ... Day by opening its doors to the community. Guided ... labs will be offered between 10 a.m. and 2 ... Dobson campus (1833 W. Southern Ave, Mesa, AZ 85202). ... AzAMI at MCC was established in the fall of ...
(Date:9/20/2014)... Las Vegas, Nevada (PRWEB) September 20, 2014 ... from its extremely successful showing at the PAIN ... and wonderful Cosmopolitan Hotel and Casino in Las ... , While MarijuanaDoctors.com primarily attended PAIN Week in ... medical marijuana as a viable and legitimate tool ...
(Date:9/19/2014)... 20, 2014 Consistent premium price ... the Vision Insurance industry in recent years; however, ... of industry margins. From 2009 to 2014, industry ... provide coverage for routine eye exams and other ... contact lens and refractive surgery. According to IBISWorld ...
(Date:9/19/2014)... Unbound , an international humanitarian organization based in ... Philippines being affected by both a tropical storm and an ... the nearest public schools while others moved to higher ground ... to portions of the northern Philippines. , The storm ... more than 10 feet of water. , “It is ...
Breaking Medicine News(10 mins):Health News:Discount Ariana Grande Tickets: QueenBeeTickets.com Delights Fans with Discount Concert Tickets for Ariana Grande’s 2015 Honeymoon Tour 2Health News:National Manufacturing Day Open House at Mesa Community College Oct. 3 2Health News:MarijuanaDoctors.com Experiences Unprecedented Support and Growth at Pain Week 2014 2Health News:Vision Insurance in the US Industry Market Research Report from IBISWorld Has Been Updated 2Health News:Vision Insurance in the US Industry Market Research Report from IBISWorld Has Been Updated 3Health News:Vision Insurance in the US Industry Market Research Report from IBISWorld Has Been Updated 4Health News:Double Threat in Philippines Displaces Thousands of Unbound Families 2
... ,Appetite Controller, Hits U.S. Market, WAYNE, N.J., ... of their appetite and eat up to 30 ... U.S. dietary supplement that offers the,breakthrough European weight ... seven clinical trials demonstrating its,effectiveness, SlimShots is poised ...
... Alzheimer,s Care, WASHINGTON, May 14 The nation,s ... Special,Committee on Aging to look to assisted living providers ... Richard Grimes, the CEO and President of the ... committee as it launched,hearings on the impact on Americans ...
... William V. Corr, Executive Director, Campaign for,Tobacco-Free Kids, ... Columbia,Council has taken a critical step to protect ... use by doubling the District,s cigarette tax to,$2 ... this life-saving measure,and urge members to also increase ...
... Woodenboat Publications first small business to receive wellness ... Anthem Blue Cross and,Blue Shield, in partnership with ... announce that Woodenboat Publications of Brooklin is the ... wellness discount through Chamber,BlueOptions. Woodenboat Publications will receive ...
... isn,t meant to encourage patients to throw out their ... researchers have some advice for those with high blood ... And watch your high blood pressure take a little ... small new study. But they aren,t suggesting anyone turn ...
... The genetic profile of two large Georgia families with ... gene that may cause the disease, researchers say. , ... common in DNA, but this pattern of SNPs shows ... says Dr. Shirley E. Poduslo, neuroscientist in the Medical ...
Cached Medicine News:Health News:New Supplement Helps Americans Eat Less Every Day 2Health News:Assisted Living Industry Looks at Future of Alzheimer's 2Health News:DC Council Delivers Victory for Kids and Taxpayers by Doubling the Cigarette Tax to $2 per Pack 2Health News:Anthem Rewards Employers for Healthy Behaviors 2Health News:Music Hath Charms to Calm Hypertension 2Health News:Families shed light on likely causative gene for Alzheimer's 2
(Date:9/19/2014)... Sept. 19, 2014 /PRNewswire-iReach/ -- "United ... 2020″, provides key market data on ... market. The report provides value, in ... (in units) within market categories – ... Esophagoscopes & Gastroscopes, Duodenoscopes, Laparoscopes, Hysteroscopes, ...
(Date:9/19/2014)... 19, 2014  The board of directors of AbbVie ... cash dividend of $0.42 per share.  ... stockholders of record at the close of business on ... a global, research-based biopharmaceutical company formed in 2013 following ... its expertise, dedicated people and unique approach to innovation ...
(Date:9/19/2014)... Medical announces the formal launch of the largest ... on the market today at this weekend,s American Orthopaedic ... Chicago .  The Osteotomy Truss System is a comprehensive ... size options included in one versatile set. Previously available ... 18 implant sizes, which limited a surgeon,s ability to ...
Breaking Medicine Technology:United States General Surgery Devices Market to 2020 - Endoscopy, Bariatric Surgery, Aesthetic Lasers and Energy, Biopsy Devices, Hernia Repair, Non-Vascular Stents 2United States General Surgery Devices Market to 2020 - Endoscopy, Bariatric Surgery, Aesthetic Lasers and Energy, Biopsy Devices, Hernia Repair, Non-Vascular Stents 3United States General Surgery Devices Market to 2020 - Endoscopy, Bariatric Surgery, Aesthetic Lasers and Energy, Biopsy Devices, Hernia Repair, Non-Vascular Stents 4United States General Surgery Devices Market to 2020 - Endoscopy, Bariatric Surgery, Aesthetic Lasers and Energy, Biopsy Devices, Hernia Repair, Non-Vascular Stents 54WEB Medical Unveils 3D-Printed Osteotomy Truss System 2
... Oct. 20 A number of costs ... over the past two and a half years. Certain ... risen by double digits during this time, increasing packaging ... largest cost components, although the majority of marketers reduced ...
... Generic Pirfenidone in India, Giving Hope to... -- MUMBAI, India, October 20, 2010 ... ... if (typeof(lpUnit)==,undefined,) var lpUnit=,PRN,; --> ... ""; BitlyCB.alertResponse = function(data) { var s = ,; var first_result; // Results are keyed by longUrl, so we ...
Cached Medicine Technology:Nonprescription Drugs Cost Structures Fluctuate with Increased Cost of Goods, According to Kline 2Nonprescription Drugs Cost Structures Fluctuate with Increased Cost of Goods, According to Kline 3Cipla Launches the World's First Generic Pirfenidone in India, Giving Hope to Sufferers of IPF (Idiopathic Pulmonary Fibrosis) 2Cipla Launches the World's First Generic Pirfenidone in India, Giving Hope to Sufferers of IPF (Idiopathic Pulmonary Fibrosis) 3Cipla Launches the World's First Generic Pirfenidone in India, Giving Hope to Sufferers of IPF (Idiopathic Pulmonary Fibrosis) 4Cipla Launches the World's First Generic Pirfenidone in India, Giving Hope to Sufferers of IPF (Idiopathic Pulmonary Fibrosis) 5Cipla Launches the World's First Generic Pirfenidone in India, Giving Hope to Sufferers of IPF (Idiopathic Pulmonary Fibrosis) 6Cipla Launches the World's First Generic Pirfenidone in India, Giving Hope to Sufferers of IPF (Idiopathic Pulmonary Fibrosis) 7Cipla Launches the World's First Generic Pirfenidone in India, Giving Hope to Sufferers of IPF (Idiopathic Pulmonary Fibrosis) 8
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... Laboratories is a national reference laboratory and ... and development. ARUP offers an extensive test ... tests in clinical and anatomic pathology. Owned ... clients include more than half of the ...
Medicine Products: