Navigation Links
Proposed drug may reverse Huntington's disease symptoms
Date:6/20/2012

With a single drug treatment, researchers at the Ludwig Institute for Cancer Research at the University of California, San Diego School of Medicine can silence the mutated gene responsible for Huntington's disease, slowing and partially reversing progression of the fatal neurodegenerative disorder in animal models.

The findings are published in the June 21, 2012 online issue of the journal Neuron.

Researchers suggest the drug therapy, tested in mouse and non-human primate models, could produce sustained motor and neurological benefits in human adults with moderate and severe forms of the disorder. Currently, there is no effective treatment.

Huntington's disease afflicts approximately 30,000 Americans, whose symptoms include uncontrolled movements and progressive cognitive and psychiatric problems. The disease is caused by the mutation of a single gene, which results in the production and accumulation of toxic proteins throughout the brain.

Don W. Cleveland, PhD, professor and chair of the UC San Diego Department of Cellular and Molecular Medicine and head of the Laboratory of Cell Biology at the Ludwig Institute for Cancer Research, and colleagues infused mouse and primate models of Huntington's disease with one-time injections of an identified DNA drug based on antisense oligonucleotides (ASOs). These ASOs selectively bind to and destroy the mutant gene's molecular instructions for making the toxic huntingtin protein.

The singular treatment produced rapid results. Treated animals began moving better within one month and achieved normal motor function within two. More remarkably, the benefits persisted, lasting nine months, well after the drug had disappeared and production of the toxic proteins had resumed.

"For diseases like Huntington's, where a mutant protein product is tolerated for decades prior to disease onset, these findings open up the provocative possibility that transient treatment
'/>"/>

Contact: Scott LaFee
slafee@ucsd.edu
619-543-6163
University of California - San Diego
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. Proposed testosterone testing of some female olympians challenged by Stanford scientists
2. Treatment of childhood OSA reverses brain abnormalities
3. Combination of 2 drugs reverses liver tumors
4. In Mice, Drug Reverses Symptoms of Condition Linked to Autism
5. Kidney Disease May Be as Harmful to Heart as Heart Attack: Study
6. New Treatments Emerging from Immune and Inflammatory Disease R&D Pipelines
7. Gum Disease, HPV May Play Role in Head & Neck Cancers
8. Device implanted in brain has therapeutic potential for Huntingtons disease
9. Control gene for conveyor belt cells could help improve oral vaccines, treat intestinal disease
10. Fruit flies reveal mechanism behind ALS-like disease
11. 1960s-era anti-cancer drug points to treatments for Lou Gehrigs disease
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Proposed drug may reverse Huntington's disease symptoms
(Date:5/30/2015)... Wixom, Michigan: Proof. Pest Control, a family-owned company focusing ... twist to its robust line of services-a 100% organic ... general pest management. , “We like killing bugs. ... Manager. “The average person cringes when they see a spider. ... that most people don’t even want to think about. ...
(Date:5/30/2015)... Key Housing, a top-rated corporate housing ... their June 2015 featured apartment community: 388 Beale Street. ... Key Housing is helping those people looking for corporate ... of the tightest apartment markets in the United States. ... anyone who requires temporary San Francisco corporate housing is ...
(Date:5/30/2015)... May 30, 2015 This year the ... with Pulmonary Horizons to offer one of the most ... and discuss successful practices to diagnose, treat and manage ... Pulmonary Horizons Conference is Interaction with Multidisciplinary ... the Overall Needs of Patients with COPD," said Brian ...
(Date:5/30/2015)... A live auction will be held to ... surgery centers and other medical facilities around the United ... radiology, surgery, endoscopy, lab, anesthesia, exam and much more. ... June 2nd starting at 10:00am EDT. The equipment is ... Hiatus Rd., Sunrise, FL 33351. Anyone can participate ...
(Date:5/30/2015)... York, NY (PRWEB) May 30, 2015 ... Wednesday, May 26th 2015, announcing that, “criminals used taxpayer-specific ... to information on approximately 100,000 tax accounts through IRS’ ... date of birth and street address.” , “You ... industry to have to think it was only a ...
Breaking Medicine News(10 mins):Health News:Proof. Pest Control-Now Offering 100% Organic Pest Control in Southeast Michigan 2Health News:San Francisco Corporate Housing Leader Key Housing Designates 388 Beale Street as Featured Community for June 2Health News:San Francisco Corporate Housing Leader Key Housing Designates 388 Beale Street as Featured Community for June 3Health News:Pulmonary Horizons 2nd Annual COPD Conference Miami Hilton Downtown, July 17-19, 2015 Patient Centered Cross-Continuum Education to Improve the Care of Patients with COPD 2Health News:Pulmonary Horizons 2nd Annual COPD Conference Miami Hilton Downtown, July 17-19, 2015 Patient Centered Cross-Continuum Education to Improve the Care of Patients with COPD 3Health News:Centurion to Sell Surplus Medical Equipment in Online and On-site Auction 2Health News:IRS Attack Exemplifies the Compounding Dangers of Stolen Personal Data 2Health News:IRS Attack Exemplifies the Compounding Dangers of Stolen Personal Data 3Health News:IRS Attack Exemplifies the Compounding Dangers of Stolen Personal Data 4Health News:IRS Attack Exemplifies the Compounding Dangers of Stolen Personal Data 5
... information about outbreak of Avian Influenza in Pakistan. ... in Pakistan, the North-Western States bordering Pakistan were ... areas especially to check informal/illegal trade of restricted ... especially of poultry and in areas visited by ...
... on a young woman, an Australian man gouged out both her ... to be the 28-year-old woman's partner, a man of around 30 ... the incident. ,The horrific string of events began ... of a Victorian country town- Malmsbury, 100 km northwest of Melbourne. ...
... is in trouble again. The Federal Drug Administration of U.S (FDA) ... pulled out of the market due to safety reasons. ... class of drugs as Vioxx ,was voted out 20-1 by ... from the market in September 2004 after research showed that it ...
... ‘chemo brain’ that chemotherapy patients complain about, is finally ... especially women have for years informed their doctors about ... to concentrate, difficulty retrieving words, trouble with multitasking and ... edge. Once brushing such complaints aside, these very people, ...
... is causing confusion among scientists, //is the mystery of ... decipher the reason for this. Normal healthy adult bees abandon the ... ago it was seen that a mass exodus would leave the ... in the new phenomenon it is seen that new bees ...
... of 95 infants were evaluated for urinary tract infection. ... as well as the diagnosis and treatment. This study ... the most common causes of unexplained fevers in infants ... ,All the patients in this study underwent renal ultrasonography, ...
Cached Medicine News:Health News:Steps To Prevent Out-Break Of Bird Flu 2Health News:Steps To Prevent Out-Break Of Bird Flu 3Health News:Arcoxia Slammed –Nothing Better Than Vioxx Says FD 2Health News:Chemo Brain- Nothing Forgettable About It 2Health News:Chemo Brain- Nothing Forgettable About It 3Health News:Vanishing Honey Bees 2
(Date:5/30/2015)... -- Eisai Inc. announced today the results of its Phase 3 ... primary endpoint evaluating overall survival in patients who had advanced ... soft tissue sarcoma. These data will be presented at the ... Clinical Oncology (ASCO) in Chicago as ... and also in an oral session on Monday, June 1 ...
(Date:5/30/2015)... IRVING, Tex. , May 30, 2015 /PRNewswire/ ... focused on fulfilling the promise of precision medicine, ... studies that demonstrate the utility of Caris Molecular ... in facilitating comparisons between tumors that share histological ... of the American Society of Clinical Oncology (ASCO) ...
(Date:5/29/2015)... OTTAWA , May 29, 2015 /CNW/ - Alliance ... Canada, is recalling the health product Galenic Health ... levels of lead for adolescents and children. The ... limits for children, but within acceptable limits for ... used to relieve digestive upset and disturbances. Alliance ...
Breaking Medicine Technology:Phase 3 Trial Investigating Eribulin in Patients with Advanced Soft Tissue Sarcoma Demonstrated Improved Overall Survival 2Phase 3 Trial Investigating Eribulin in Patients with Advanced Soft Tissue Sarcoma Demonstrated Improved Overall Survival 3Phase 3 Trial Investigating Eribulin in Patients with Advanced Soft Tissue Sarcoma Demonstrated Improved Overall Survival 4Phase 3 Trial Investigating Eribulin in Patients with Advanced Soft Tissue Sarcoma Demonstrated Improved Overall Survival 5Phase 3 Trial Investigating Eribulin in Patients with Advanced Soft Tissue Sarcoma Demonstrated Improved Overall Survival 6Caris Molecular Intelligence Multi-Platform Tumor Profiling Facilitates Comparisons between Tumors that Share Histological Features 2Caris Molecular Intelligence Multi-Platform Tumor Profiling Facilitates Comparisons between Tumors that Share Histological Features 3Caris Molecular Intelligence Multi-Platform Tumor Profiling Facilitates Comparisons between Tumors that Share Histological Features 4Caris Molecular Intelligence Multi-Platform Tumor Profiling Facilitates Comparisons between Tumors that Share Histological Features 5Caris Molecular Intelligence Multi-Platform Tumor Profiling Facilitates Comparisons between Tumors that Share Histological Features 6
... SPRINGS, Calif., Feb. 18, 2012 A national coalition ... medication is inviting area residents to safely dispose of ... pharmacies today.   Sponsored by the Collaborating ... the event comes as pain medicine providers prepare to ...
... CHAPEL HILL, N.C., Feb. 17, 2012  Communication channels are ... to seek the ones that drive efficient performance, ... With so many communications options, companies need to ... most effective, and how to best use them. ...
Cached Medicine Technology:National Coalition Holds Prescription Drug Take-back Day in Palm Springs Ahead of Pain Medicine Scientific Meeting 2National Coalition Holds Prescription Drug Take-back Day in Palm Springs Ahead of Pain Medicine Scientific Meeting 3National Coalition Holds Prescription Drug Take-back Day in Palm Springs Ahead of Pain Medicine Scientific Meeting 4Effective Communication Options to Increase Organizational Effectiveness 2
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
Medicine Products: