Navigation Links
Propofol's effect on the sciatic nerve: Harmful or protective?
Date:10/31/2013

Propofol is a rapid, but short-acting, intravenous drug that is preferentially used for the induction and maintenance of anesthesia. Propofol can inhibit inflammation and suppress the secretion of the proinflammatory cytokines interleukin-1, interleukin-6 and tumor necrosis factor alpha from astrocytes, and enhance the synthesis and release of the anti-inflammatory cytokine interleukin-10. Consequently, propofol can inhibit damage caused by proinflammatory cytokines and exert protective effects on the central nervous system. A recent study published in the Neural Regeneration Research (Vol. 8, No. 27, 2013) showed that after propofol was injected into the injured sciatic nerve of mice, nuclear factor kappa B expression in the L46 segments of the spinal cord in the injured side was reduced, apoptosis was decreased, nerve myelin defects were alleviated, and the nerve conduction block was lessened. The experimental findings indicate that propofol inhibits the inflammatory and immune responses, decreases the expression of nuclear factor kappa B, and reduces apoptosis. These effects of propofol promote regeneration following sciatic nerve injury.


'/>"/>

Contact: Meng Zhao
eic@nrren.org
86-138-049-98773
Neural Regeneration Research
Source:Eurekalert  

Page: 1

Related medicine news :

1. Young girls more likely to report side effects after HPV vaccine
2. Preteens More Likely to Report HPV Vaccine Side Effects
3. In children born with severe heart defect, surgical management has little effect on neuro outcomes
4. Novel compound demonstrates anti-leukemic effect in zebrafish, shows promise for human treatment
5. Breast cancer patients suffer treatment-related side effects long after completing care
6. Breast Cancer Treatment Side Effects May Last for Years
7. Baldness Drug May Cause Sexual Side Effects: FDA
8. Study examines adverse effects among different radiation therapies for prostate cancer
9. HIV Prevention Pill Cost-Effective for High-Risk Men: Study
10. Pig stomach mucins are effective as anti-viral agents for consumer products
11. LA BioMeds Dr. John Tsuang examines effects of Ibudilast and metamphetamines
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Propofol's effect on the sciatic nerve: Harmful or protective?
(Date:6/24/2017)... Fla. (PRWEB) , ... June 24, 2017 , ... ... is now offering genetic testing for medications in select Florida and Texas doctors' ... pharmacogenomics. , This new application of genetic testing recognizes the role genes ...
(Date:6/24/2017)... , ... June 24, 2017 , ... The weather is ... time outdoors. Home and business owners should be aware that the summer months provide ... In fact, mechanical locks and keys can be negatively affected from direct exposure to ...
(Date:6/23/2017)... ... June 23, 2017 , ... ... and will ultimately do significant harm to people with all chronic conditions, including ... "While it leaves in place the Affordable Care Act (ACA) requirement that insurers ...
(Date:6/23/2017)... ... June 24, 2017 , ... Studies show evidence that carotenoids and ... of visual loss in these patients. , But how often do ophthalmologists and optometrists ... to patients at risk of or with early symptoms of AMD? A study ...
(Date:6/23/2017)... ... 2017 , ... Military Connection friend and veteran advocate Micaela Bensko ... Atlantic lounge. , Bensko is no stranger to the plight of the disabled. ... life to supporting our wounded veterans. A world-class photographer, her riveting photos “The Wounds ...
Breaking Medicine News(10 mins):
(Date:5/26/2017)...  In response to the opioid epidemic in ... working with Pfizer to make up to 1 million ... community health centers, free and charitable clinics, public health ... "Pfizer has a long-standing commitment to improving health outcomes ... through educational activities," said Caroline Roan , vice ...
(Date:5/23/2017)... Calif. , May 23, 2017  Leaf ... most innovative medical devices for pressure ulcer prevention, ... the American Association of Critical Care Nurses, National ... May 22-25. The Leaf Patient Monitoring ... specifically for the hospital environment.  The system seamlessly ...
(Date:5/22/2017)... , May 22, 2017  As the ... a whole continue to make the revolutionary shift ... increasingly important for ensuring positive patient outcomes and ... stakeholders are shifting focus away from clinical trials ... effects of long-term specialty drug therapy utilization in ...
Breaking Medicine Technology: