Navigation Links
Promoting healing by keeping skeletal stem cells 'young'
Date:3/30/2010

in the bone marrow and other tissues.

The team showed that Notch prevents stem cells from maturing. When the scientists activated the Notch pathway, the stem cells didn't progress as usual. Instead, they remained indefinitely in an immature state and did not go on to become bone cells, cartilage cells, or cells for connective tissue.

The team also settled a long-standing question, fingering the molecule RBPJ-kappa as the molecule through which Notch works in mesenchymal stem cells. That knowledge is crucial for scientists trying to understand precisely how Notch works in bone and cartilage development. A few years ago, Hilton was part of a team that showed that Notch is a critical regulator of the development of bone and cartilage. The latest study extends those observations, providing important details that suggest appropriate activation and manipulation of the Notch pathway may provide doctors with a tool to maintain and expand mesenchymal stem cells for use in treating disease.

The work is part of ongoing research around the world aimed at harnessing the promise of stem cells for human health. Unfortunately, stem cell therapy has been slow to actually make a difference in the lives of patients with problems of the bones and cartilage, Hilton notes, largely because so many questions are currently unanswered.

"To really make stem-cell medicine work, we need to understand where the stem cells have come from and how to get them to become the cell you want, when and where you want it. We are definitely in the infancy of learning how to manipulate stem cells and use them in treatment," said Hilton, assistant professor of Orthopaedics and Rehabilitation.

"This research helps set the foundation for ultimately trying new therapies in patients," he added. "For instance, let's say a patient has a fracture that simply won't heal. The patient comes in and has a sample of bone marrow drawn. Their skeletal stem cells are isolated and
'/>"/>

Contact: Tom Rickey
tom_rickey@urmc.rochester.edu
585-275-7954
University of Rochester Medical Center
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. National Nutrition Month Kicks Off with Hottest Celebrity Diet Trend: Fiber -- F-Factor Diet Book Promoting Fiber Soars Up Best-Sellers List
2. Chitosan as alternative to growth-promoting antibiotics for ruminants
3. BABYCENTER Partners In Promoting Safe And Healthy Pregnancies Through Text4baby
4. Massage Fosters Healing in Bereaved Relatives
5. Secret to healing chronic wounds might lie in tiny pieces of silent RNA
6. Healing Wounds and Hearts: Warrior Weekend Helps Soldiers and Marines Relax and Recover
7. Master Zhi Gang Sha Dedicates Soul Healing Blessings for Humanity Service to Chile's Earthquake Victims
8. A novel in vitro model for light-induced wound healing
9. New Book, "Healing," Claims "What's Ailing The U.S. is What's Ailing Us All" - Offers Healing Self-Love
10. New Book, Healing, Claims Whats Ailing the U.S. is Whats Ailing Us All - Offers Healing Self-Love
11. Wound-Healing Maggots Succumb to Deadly Bacteria
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/2/2015)... (PRWEB) June 02, 2015 ZOOM+, the ... ZOOM+ Performance Health Insurance, announced today the opening of ... White 57 - a three-in-one complete dental exam, cleaning ... Jr. for kids. Like all ZOOM+ services, ZOOM+Smile can ... “Why shouldn’t the dentist office be as inviting as ...
(Date:6/2/2015)... With a dedicated focus to become an ... has hired Leslie Young as director of human resources ... to better understand and respond to the distinct needs of ... in 13 states across the country. , “As we intensify ... to our residents, we are making it an equal priority ...
(Date:6/2/2015)... Alberta (PRWEB) June 02, 2015 ... wireless technology, highlights North Pole Engineering’s (NPE) announcement ... ANT Wireless technologies: WASP-N, WASP-PoE-2 and WASP-PoE-3. WASP ... ANT-FS) and Bluetooth Smart® bridge solution that allows ... transmitted over WiFi or Ethernet networks. ...
(Date:6/2/2015)... 2015 For those that have ever ... to harmful germs, chemicals and bodily fluids from each ... an inventor from Queens Village, N.Y., their worries are ... efficient, fun, hygienic way to store and dispense toothpaste. ... bugs, chemicals and germs. Furthermore, it insures that all ...
(Date:6/2/2015)... Vancouver, BC – According to ... http://www.idataresearch.com ), the bone graft substitute market is ... over traditional allograft materials. Because the use of ... increase in operation time, alternative graft options are ... these synthetic materials is partly the result of ...
Breaking Medicine News(10 mins):Health News:ZOOM+ Opens Its First On-Demand ZOOM+Smile Studio and Reinvents the Dental Exam 2Health News:Tutera Senior Living & Health Care Hires HR Pro Leslie Young to Lead New Initiatives to Become Employer of Choice 2Health News:Tutera Senior Living & Health Care Hires HR Pro Leslie Young to Lead New Initiatives to Become Employer of Choice 3Health News:Tutera Senior Living & Health Care Hires HR Pro Leslie Young to Lead New Initiatives to Become Employer of Choice 4Health News:ANT Technology Incorporated in Second Generation WASP Bridge Products 2Health News:ANT Technology Incorporated in Second Generation WASP Bridge Products 3Health News:Dental Storage and Dispensing Unit Invented by InventHelp Client (LGI-1890) 2Health News:Medtronic, DePuy Synthes Shift U.S. Bone Graft Substitute Market Towards Synthetic Demineralized Bone Matrices 2Health News:Medtronic, DePuy Synthes Shift U.S. Bone Graft Substitute Market Towards Synthetic Demineralized Bone Matrices 3
... Men worried about taking finasteride, a drug proven effective in ... performance in the bedroom, can now put their fears ... study, by researchers from the Southwest Oncology Group, found that ... the effects diminish over the course of time. ...
... revealed that the reason behind her battle with Insomnia is her ... she is struggling with the sleep disorder, because her songs keep ... most of her lyrics and hits strike her when she's trying ... has to write them down or record them on the spot, ...
... Health authorities of Ukraine are not taking any chances. Following ... yellow phosphorous, they have examined around 16, 000 ... The incident near the Polish border (outside Lviv) was caused ... parked tankers holding the chemical. ,Health practioners examined thousands ...
... a country which has been named the epicentre of the gourmet ... book on Spanish gastronomy said Thursday. ,"There is ... many things," said Miguel Angel Rincon, who has just published "Un ... cooking in Madrid). ,Rincon came up with the book ...
... seems to ask the government of India.,Clearly positing development against ... the so-called Green Bench that sits over environmental issues. ... the Forest Advisory Committee (FAC), constituted under the Forest Conservation ... up its Green Bench on the ground that it has ...
... to his estranged wife Heather Mills in divorce settlement, but ... reports are to be believed. ,Earlier, it was ... of somewhere between 25 to 30 million pounds out of ... their stubbornness is now indicating that they may finally have ...
Cached Medicine News:Health News:Mens Sexual Prowess Not Affected by Prostate Cancer Drug 2Health News:Ukrainian Town Under A Canopy Of Toxic Skies 2Health News:Indian Government Asks the Supreme Court to Keep Off Environmental Issues 2Health News:Indian Government Asks the Supreme Court to Keep Off Environmental Issues 3Health News:Indian Government Asks the Supreme Court to Keep Off Environmental Issues 4
(Date:6/2/2015)... 2015 ANI Pharmaceuticals, Inc. ("ANI") (NASDAQ: ... from the U.S. Food and Drug Administration (FDA) of ... Oral Solution 5mg/5mL. Trailing twelve-month sales for the product ... competitors. ANI expects to begin shipping to its customers ... and CEO of ANI Pharmaceuticals, stated, "This ANDA represents ...
(Date:6/2/2015)... 2015  Integrated Service Solutions, Inc. ("the Company") announced today they are expanding their reach nationally by providing customers with on-site ... ... ... ... Photo - http://photos.prnewswire.com/prnh/20150601/219758 ...
(Date:6/2/2015)... Mass. , June 2, 2015  Psychemedics Corporation ... leader for over twenty-five years, announced the addition of ... In response to growing abuse concerns, the addition of ... and D-Amphetamine/Adderall® was added as an option to the ... Chairman and CEO stated:  "Sadly, more and more prescription ...
Breaking Medicine Technology:ANI Pharmaceuticals Announces FDA Approval of Oxycodone Hydrochloride Oral Solution 5mg/5mL 2ANI Pharmaceuticals Announces FDA Approval of Oxycodone Hydrochloride Oral Solution 5mg/5mL 3Integrated Service Solutions, Inc. Announces Nationwide Expansion for On-site Pipette Calibrations 2Integrated Service Solutions, Inc. Announces Nationwide Expansion for On-site Pipette Calibrations 3Integrated Service Solutions, Inc. Announces Nationwide Expansion for On-site Pipette Calibrations 4Psychemedics Announces Addition Of FDA Cleared Drugs 2Psychemedics Announces Addition Of FDA Cleared Drugs 3
... , , RARITAN, N.J., ... L.L.C. announced today that it has submitted a New Drug ... for tapentadol extended release (ER) tablets, an investigational oral analgesic ... patients 18 years of age or older. , Chronic ...
... , NEW YORK, Dec. 1 Reportlinker.com ... in its catalogue: , Molecular Diagnostics - A ... Molecular diagnostics market is being driven by several growth ... techniques, which combine optimized sample preparation, analysis, and data ...
Cached Medicine Technology:New Drug Application Submitted to FDA for Tapentadol Extended Release Tablets for Management of Chronic Pain 2New Drug Application Submitted to FDA for Tapentadol Extended Release Tablets for Management of Chronic Pain 3New Drug Application Submitted to FDA for Tapentadol Extended Release Tablets for Management of Chronic Pain 4New Drug Application Submitted to FDA for Tapentadol Extended Release Tablets for Management of Chronic Pain 5New Drug Application Submitted to FDA for Tapentadol Extended Release Tablets for Management of Chronic Pain 6New Drug Application Submitted to FDA for Tapentadol Extended Release Tablets for Management of Chronic Pain 7Reportlinker Adds Molecular Diagnostics - A World Market Review 2Reportlinker Adds Molecular Diagnostics - A World Market Review 3Reportlinker Adds Molecular Diagnostics - A World Market Review 4Reportlinker Adds Molecular Diagnostics - A World Market Review 5Reportlinker Adds Molecular Diagnostics - A World Market Review 6Reportlinker Adds Molecular Diagnostics - A World Market Review 7
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... ARUP Laboratories is a national reference laboratory ... research and development. ARUP offers an extensive ... medical tests in clinical and anatomic pathology. ... Laboratories' clients include more than half of ...
Medicine Products: