Navigation Links
Promising strategy for treatment of lung cancer
Date:3/29/2010

A research team at the Sahlgrenska Academy at the University of Gothenburg, Sweden, has shown in a study that two closely related enzymes could be targets for the treatment of lung cancer. The discovery was made when the researchers blocked the production of the two enzymes in transgenic mice. This resulted in inhibition of cell growth, fewer tumours and greater survival among the mice.

The article is being published in the journal Proceedings of the National Academy of Sciences (PNAS). With many types of cancer, the growth and spread of tumours is stimulated by Ras and Rho proteins. For these proteins to function, they need to be modified by the closely related enzymes FT and GGT. A number of pharmaceutical companies have therefore developed substances that reduce the activity of these two enzymes with the aim of inhibiting the function of Ras and Rho proteins and so slowing the development of the disease.

However, treatment with various substances to block these two enzymes has often been non-specific, and their efficacy has varied widely. This has made it difficult for researchers to assess the true potential of these enzymes as targets for medicines.

"We therefore developed genetic strategies in mice, known as transgenic mice, to switch off the genes coding for FT and GGT, enabling us to investigate whether a complete blockade of FT or GGT can inhibit the development of lung cancer, and whether this has side-effects in the lungs," explains researcher Anna-Karin Sjgren, who led the study together with Meng Liu, both from the Department of Clinical and Molecular Medicine.

In their study, the researchers used transgenic mice which produce a mutated Ras protein that causes lung cancer. First, production of FT or GGT in these mice's lungs was stopped by switching off the relevant genes.

"When we turned off the FT gene, the mice developed fewer lung tumours and lived longer," says Meng Liu. "At cellular level, the blockade of FT meant that the tumour cells were no longer able to divide. When we blocked the production of GGT, we saw the same effects: inhibition of cell growth, fewer lung tumours and improved survival."

In experiments where both genes were switched off at the same time, the number of lung tumours dropped sharply and the mice lived much longer. This means that the absence of these two enzymes does not have any obvious side-effects in the lungs, and that lung tumour cells seem to be more sensitive to the treatment than normal lung cells.

"Our findings show that FT and GGT are promising targets for the treatment of lung cancer," the researchers explain. "The next step in our research is to find out whether blocking these enzymes can have side-effects in other tissues."


'/>"/>

Contact: Anna-Karin Sjgren
anna-karin.sjogren@wlab.gu.se
46-031-342-4723
University of Gothenburg
Source:Eurekalert

Related medicine news :

1. SBRT eliminates tumors with promising survival for early-stage inoperable lung cancer patients
2. New smoking cessation therapy proves promising
3. Lacosamide validated as promising therapy for uncontrolled partial-onset seizures
4. Sytropin HGH Shows Promising Anti-Aging Results
5. New strategy produces promising advance in cancer vaccines
6. Promising therapy for relapsing multibple sclerosis
7. First blinded study of venous insufficiency prevalence in MS shows promising results
8. UH Case Medical Center researchers publish promising findings for advanced cervical cancer
9. Promising new neuroimaging techniques for early detection of Alzheimers disease
10. LSUHSC research yields promising stroke treatment
11. Promising New Results On The Added Safety Of Using SmokeStik Electronic Cigarettes In The Bid To Quit Smoking
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2016)... ... May 25, 2016 , ... Casa Velas, an adults-only boutique ... precious stones to complement its new wellness suites . The two 1,350 sq. ... a plethora of special services and insuite amenities, from a custom soap selection and ...
(Date:5/25/2016)... ... 25, 2016 , ... Laser Skin & Wellness Center is excited ... time of female aging. The Juliet™ procedure helps to reverse the ... leakage, laxity, itchiness and pain have reported real relief from these and other problems ...
(Date:5/25/2016)... TX (PRWEB) , ... May 25, 2016 , ... ... the United States, named Dr. Anh Tat Nguyen, as the Medical Director of its ... the facility Medical Director of our new DeSoto location,” said Dr. James M. Muzzarelli, ...
(Date:5/24/2016)... ... May 24, 2016 , ... Sterling Global Products is launching a Kickstarter campaign ... hanging wipe dispenser. The campaign kick-off video is located via this link https://youtu.be/WsO4qz2odco ... The goal is to raise $1,000 per day for a total of $25,000. The ...
(Date:5/24/2016)... ... May 24, 2016 , ... Women's Excellence ... Roberta Jordan is a Certified Nurse Midwife who was born and raised in ... went on to complete her masters degree from the University of Mexico. Roberta ...
Breaking Medicine News(10 mins):
(Date:5/24/2016)... -- Niederländische Chirurgen haben eine innovative ... erlaubt, ihre Expertise weltweit zu teilen und so ... mit einer Instant-Messaging-Funktion und der Möglichkeit, in einem ... Afrika, Asien und den USA ... Information und Weiterbildung   "MDLinking ...
(Date:5/24/2016)... New Zealand , May 24, 2016 ... and informatics solutions for the healthcare sector, has been named ... New Zealand Hi-Tech Awards 2016. Dr Bruce ... fantastic acknowledgement for our team.  It,s really good to be ... burden healthcare internationally. Our products are used in 35 countries ...
(Date:5/24/2016)... 2016 Los innovadores de ... mundo, introduce catéteres para la intervención de extremidades ... compañía global especializada en el suministro de soluciones ... cartera incluyendo productos para tratar la enfermedad arterial ... son los dispositivos de primera entrada de la ...
Breaking Medicine Technology: