Navigation Links
Promising new neuroimaging techniques for early detection of Alzheimer's disease
Date:1/29/2010

Amsterdam, January 29, 2010 Investigators from the International Center for Biomedicine and the University of Chile, in collaboration with the Center for Bioinformatics of the Universidad de Talca, have discovered that two drugs, the benzimidazole derivatives lanzoprazole and astemizole, may be suitable for use as PET (positron emission tomography) radiotracers and enable imaging for the early detection of Alzheimer's Disease. The study is published in the current issue of the Journal of Alzheimer's Disease.

Lanzoprazole and astemizole specifically tag pathological oligomers of tau which form the core of neurofibrillary tangles (NFTs), a pathognomonic brain lesion in Alzheimers patients. Prof. Dr. R.B. Maccioni and Dr. Leonel Rojo, authors of the study commented, "Since neurofibrillary tangles are positively correlated with cognitive impairment, we propose that these drugs have great potential in PET neuroimaging for in vivo early detection of AD and in reducing the formation of NFTs. These studies, based on advanced proteomics and databases of molecular interactions, may help to find potential new drugs for early diagnosis and treatment of Alzheimers disease. The findings are the result of a long-standing research program supported by the Alzheimers Association-USA and Fondecyt, Chile to evaluate new drug candidates." Technological applications of this discovery are being developed with the collaboration of VentureL@b of the Universidad Adolfo Ibaez.

Interestingly, lanzoprazole and astemizole, already approved for treatment of proton pump disorders and as an antihistamine respectively, specifically bind directly to aggregated variants of tau protein, paired helical filaments (PHFs) and NFTs in Alzheimers brains. Until now it has not been possible to detect these pathological brain structures in living Alzheimers patients. The only confirmation of the disease has been attained by postmortem neuropathological evaluation.

Dr. M
'/>"/>

Contact: Esther Mateike
e.mateike@iospress.n
31-206-883-355
IOS Press
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Promising drug combination may help those with ocular melanoma that has spread
2. Promising Phase 3 trial results show biologic therapy ustekinumab significantly improved psoriasis
3. Molecule Promising Against Huntingtons Disease
4. Computerized training of working memory is a promising therapeutic strategy in ADHD
5. Baicalin might be a promising therapeutic tool for severe acute pancreatitis
6. Initial Evaluation of New Nucleus Removal Device Provides Promising Results
7. Promising new TB drug given special status by US and European regulators
8. New Drug Promising Against Tough-to-Treat Kidney Cancer
9. Einstein scientists treat cancer as an infectious disease -- with promising results
10. Thomson Scientific Publishes its Third Quarter Issue of the Ones to Watch Reviewing the Most Promising Drugs in the Pharmaceutical Pipeline
11. Protalix BioTherapeutics prGCD Named One of the Five Most Promising Drugs Entering Phase III Trials by Thomson Scientific
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/22/2014)... CA (PRWEB) July 22, 2014 Mona ... instructor certification on August 15th & 16th, 2014, at ... industry's only structured and nationally accredited Bollywood workout was ... Powered by the globally appealing Bollywood culture, Bombay Jam® ... safe, easy to follow and designed with authentic Bollywood ...
(Date:7/22/2014)... IN (PRWEB) July 22, 2014 United ... advisory organization, announces that Les McPhearson, an insurance veteran ... as CEO effective immediately and be based in the ... said, "I am delighted that Les chose to accept ... perfectly qualified to address the many challenges facing UBA ...
(Date:7/22/2014)... The American Society of Hematology (ASH) will honor Tomas ... Los Angeles with the 2014 E. Donnall Thomas Lecture ... discovery of the iron-regulatory hormone hepcidin and investigation of ... the Nobel Prize Laureate and past Society president E. ... that have represented a paradigm shift or significant discovery ...
(Date:7/22/2014)... to heart disease, Dr. Ross Feldman says women are often ... was a men,s-only disease, however, data has shown that post-menopausal ... disease and are less likely to be adequately diagnosed and ... in the British Journal of Clinical Pharmacology brings ... and helps to identify which women are more prone to ...
(Date:7/22/2014)... disorders may share certain pathogenic mechanisms with cancer, according ... researcher Linda Kusner, Ph.D. , published in ... shifting work shows that the very same inhibitors of ... in cells that produce autoimmune diseases. Henry Kaminski, ... the GW School of Medicine and Health Sciences (SMHS), ...
Breaking Medicine News(10 mins):Health News:Mona Khan Company Announces Bombay Jam® Instructor Certification in Los Angeles in August 2014 2Health News:Mona Khan Company Announces Bombay Jam® Instructor Certification in Los Angeles in August 2014 3Health News:Industry Leader Les McPhearson Joins United Benefit Advisors as New Chief Executive Officer 2Health News:Industry Leader Les McPhearson Joins United Benefit Advisors as New Chief Executive Officer 3Health News:Industry Leader Les McPhearson Joins United Benefit Advisors as New Chief Executive Officer 4Health News:Industry Leader Les McPhearson Joins United Benefit Advisors as New Chief Executive Officer 5Health News:Tomas Ganz, M.D., Ph.D., to present 2014 ASH E. Donnall Thomas Lecture 2Health News:Tomas Ganz, M.D., Ph.D., to present 2014 ASH E. Donnall Thomas Lecture 3Health News:Gene variant identified as a heart disease risk factor for women 2Health News:New research finds pathogenic connection between autoimmune disorders and cancer 2
... the United States via Haiti, probably arriving in just one ... new research. , After the virus, HIV-1, entered the ... results show that the strain of virus that spawned the ... is earlier than a lot of people had imagined," said ...
... born and die without leaving a trace in any ... which to base public health decisions, a University of ... in a paper published today (Oct. 29, 2007) in ... solutions exist to collect these vital statistics and must ...
... prevent or shorten the illness , MONDAY, Oct. 29 (HealthDay ... help prevent pneumonia in elderly nursing home residents, a new ... at 617 people 65 and older in 33 nursing homes ... normal blood zinc concentrations were about 50 percent less likely ...
... Launch National Campaign to Inspire and ... Educate that Prevention is Possible, BERKELEY, Calif., Oct. 29 ... their lifetime. Although 50 percent,of women think breast cancer is hereditary, ... the disease. LUNA, the makers of whole nutrition bars for ...
... produced responses in 40% of patients with Philadelphia, chromosome-positive chronic myeloid ... ... and availability in US means Novartis can offer physicians and ... EAST HANOVER, N.J., Oct. 29 Tasigna(R),(nilotinib) capsules have been approved in ...
... and Los Angeles provide foundation for new education ... and research efforts to fight IPF, ... is pleased to announce that two major fundraising events,hosted in Chicago ... help those suffering from idiopathic pulmonary fibrosis (IPF), a,rare and deadly ...
Cached Medicine News:Health News:HIV's path out of Africa: Haiti, the US then the world 2Health News:HIV's path out of Africa: Haiti, the US then the world 3Health News:Scandal of invisibility plagues countries with no civil registries 2Health News:Scandal of invisibility plagues countries with no civil registries 3Health News:Zinc Helps Elderly Ward Off Pneumonia 2Health News:LUNA Pure Prevention Survey Confirms Breast Cancer Misconceptions 2Health News:LUNA Pure Prevention Survey Confirms Breast Cancer Misconceptions 3Health News:Video and Photo: Tasigna(R) Receives US Approval Providing New Hope to Chronic Myeloid Leukemia Patients With Resistance or Intolerance to Existing Therapies 2Health News:Video and Photo: Tasigna(R) Receives US Approval Providing New Hope to Chronic Myeloid Leukemia Patients With Resistance or Intolerance to Existing Therapies 3Health News:Video and Photo: Tasigna(R) Receives US Approval Providing New Hope to Chronic Myeloid Leukemia Patients With Resistance or Intolerance to Existing Therapies 4Health News:Video and Photo: Tasigna(R) Receives US Approval Providing New Hope to Chronic Myeloid Leukemia Patients With Resistance or Intolerance to Existing Therapies 5Health News:Video and Photo: Tasigna(R) Receives US Approval Providing New Hope to Chronic Myeloid Leukemia Patients With Resistance or Intolerance to Existing Therapies 6Health News:Video and Photo: Tasigna(R) Receives US Approval Providing New Hope to Chronic Myeloid Leukemia Patients With Resistance or Intolerance to Existing Therapies 7Health News:Video and Photo: Tasigna(R) Receives US Approval Providing New Hope to Chronic Myeloid Leukemia Patients With Resistance or Intolerance to Existing Therapies 8Health News:Video and Photo: Tasigna(R) Receives US Approval Providing New Hope to Chronic Myeloid Leukemia Patients With Resistance or Intolerance to Existing Therapies 9Health News:Video and Photo: Tasigna(R) Receives US Approval Providing New Hope to Chronic Myeloid Leukemia Patients With Resistance or Intolerance to Existing Therapies 10Health News:Coalition for Pulmonary Fibrosis Fundraising Events Raise $280,000 for IPF 2Health News:Coalition for Pulmonary Fibrosis Fundraising Events Raise $280,000 for IPF 3
(Date:7/22/2014)... 22, 2014  Halozyme Therapeutics, Inc. (NASDAQ: ... and dosing of patients in its ongoing Phase 2 ... cancer under the revised clinical protocol agreed to with ... form of Halozyme,s proprietary recombinant human hyaluronidase under development ... "Our diligent effort to rapidly re-initiate ...
(Date:7/22/2014)... , July 22, 2014  Neurotrope Bioscience, Inc., a ... world-wide, exclusive license agreement with the Icahn School of ... Mount Sinai ) to utilize its proprietary ... in the treatment of Niemann-Pick Type C Disease (NPC), ... with Alzheimer-like symptoms. The license also covers other diseases ...
(Date:7/22/2014)... BioDelivery Sciences International, Inc. (BDSI) (NASDAQ: ... has appointed Charles J. (Chuck) Bramlage and ... the Board.  Mr. Bramlage is a ... sales and other commercial functions.  He is currently the ... stage company that was recently acquired by AstraZeneca and ...
Breaking Medicine Technology:Halozyme Resumes Patient Enrollment And Dosing In PEGPH20 Clinical Program In Pancreatic Cancer 2Halozyme Resumes Patient Enrollment And Dosing In PEGPH20 Clinical Program In Pancreatic Cancer 3Neurotrope Enters Collaborative Agreement with Icahn School of Medicine at Mount Sinai for use of Bryostatin-1 in the Treatment of Niemann-Pick Disease Type C 2Neurotrope Enters Collaborative Agreement with Icahn School of Medicine at Mount Sinai for use of Bryostatin-1 in the Treatment of Niemann-Pick Disease Type C 3Neurotrope Enters Collaborative Agreement with Icahn School of Medicine at Mount Sinai for use of Bryostatin-1 in the Treatment of Niemann-Pick Disease Type C 4Neurotrope Enters Collaborative Agreement with Icahn School of Medicine at Mount Sinai for use of Bryostatin-1 in the Treatment of Niemann-Pick Disease Type C 5BioDelivery Sciences Appoints Charles J. Bramlage and Dr. Barry I. Feinberg to its Board of Directors 2BioDelivery Sciences Appoints Charles J. Bramlage and Dr. Barry I. Feinberg to its Board of Directors 3BioDelivery Sciences Appoints Charles J. Bramlage and Dr. Barry I. Feinberg to its Board of Directors 4BioDelivery Sciences Appoints Charles J. Bramlage and Dr. Barry I. Feinberg to its Board of Directors 5BioDelivery Sciences Appoints Charles J. Bramlage and Dr. Barry I. Feinberg to its Board of Directors 6BioDelivery Sciences Appoints Charles J. Bramlage and Dr. Barry I. Feinberg to its Board of Directors 7
... WOONSOCKET, R.I., Oct. 18, 2011 A recent ... up germs, they are not doing all they can to ... receiving an annual flu shot as recommended by the Centers ... http://photos.prnewswire.com/prnh/20100816/NE50800LOGO) The CDC recommends that anyone ages 6 ...
... With connectivity enabled by Unlimited Systems Interlink integration ... only helps cancer clinics easily meet many of the ... saves time and money by reducing duplicate data entry, ... claims payment and reduced denials. Clinics can ...
Cached Medicine Technology:CVS/pharmacy Survey Reveals Consumer Misconceptions Standing in the Way of Getting a Flu Shot 2CVS/pharmacy Survey Reveals Consumer Misconceptions Standing in the Way of Getting a Flu Shot 3CVS/pharmacy Survey Reveals Consumer Misconceptions Standing in the Way of Getting a Flu Shot 4Navigating Cancer and Unlimited Systems Partner to Provide Cancer Clinics With IT Interoperability to Attain HITECH Act Incentives 2
... Hand Instruments were developed in surgeon's desire ... still having an instrument with the strength ... fear of the bending or breaking. Arthrotek ... to conform to the surgeon's hand. This ...
... Arthrotek® Precision Hand Instruments were developed in ... feel, while still having an instrument with ... without the fear of the bending or ... and manufactured to conform to the surgeon's ...
A straightforward, versatile approach to arthroscopically assisted pin placement in either the ankle or wrist....
... SureStep Drug Screen Tests are available in ... MDMA (Ecstasy). Designed using Microgenics Antibody Technology, ... only point of care immunoassay targeted to ... both MDA and MDEA but no cross-reactivity ...
Medicine Products: