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Promising new approach to treating debilitating nervous system disease
Date:10/16/2011

mpared diseased mice that had been treated with VEGF to diseased mice that received no treatment. The VEGF group performed significantly better than the untreated mice -- and in some cases nearly as well as healthy mice that did not have SCA1. In addition, microscopic examinations found significant improvements in the brains of diseased mice that had been treated with VEGF.

The findings suggest that reversing low VEGF levels "may be a potentially useful treatment in patients with SCA1," researchers wrote.

The results also could prove relevant to other ataxia disorders "and possibly even other neurodegenerative syndromes," researchers wrote.

However, Kini cautioned that while the study findings are promising, they do not necessarily apply to humans. It would require clinical trials in patients to prove that replenishing VEGF levels is a safe and effective treatment, Kini said.


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Contact: Jim Ritter
jritter@lumc.edu
708-216-2445
Loyola University Health System
Source:Eurekalert

Page: 1 2

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