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Promising medication counteracts constipation caused by opioid painkillers
Date:7/16/2014

ing opioid-induced constipation.

The researchers tested the pill's efficacy in two phase 3 studies with promising results. Naloxegol was shown to maintain opioids' pain-killing effect in the brain and block their effects in the bowels. Bowel function in all of the 1,400 test subjects returned to normal and accompanying stomach pain and other discomforts decreased. No patients experienced a diminished pain-relieving effect as a result of the drug.

While the studies addressed in the paper focused on patients taking opioids for non-cancer pain such as back pain and other musculoskeletal ailments, similar studies are now underway to examine the effect of naloxegol in patients with chronic cancer-related pain.

Final regulatory approval for the drug is pending in the United States and Europe.


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Contact: Jan Tack
jan.tack@med.kuleuven.be
321-634-4225
KU Leuven
Source:Eurekalert

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