Navigation Links
Promising medication counteracts constipation caused by opioid painkillers
Date:7/16/2014

Opioids strong morphine-based painkillers are widely prescribed to patients experiencing chronic severe pain. While these drugs are very effective for treating and managing pain, they have one particularly bothersome side effect: constipation. A new drug, called naloxegol, could bring relief. In stage 3 trials reported in the New England Journal of Medicine, KU Leuven and international researchers provide new evidence that the drug relieves constipation without dulling opioids' pain-relieving effects.

Up until a decade ago, physicians rarely prescribed opioids, reserving them primarily for the terminally sick. Today, opioid-based drugs have proliferated thanks to their 'user-friendliness' and effectiveness. Millions of patients take opioids on a daily basis to manage lower back pain and chronic joint problems. Opioids also play a critical role in pain management regimes for cancer patients.

However, opioids have a number of side effects, including nausea, vomiting and notoriously constipation. Opioids block pain by binding to 'mu-receptors' in the brain. But they also bind to mu-receptors in the bowels, and this causes constipation.

Some sixty percent of patients that take opioid pain relievers experience constipation. For some, the bother is so great that they choose to stop taking the drug.

A newly developed opioid antagonist called naloxegol may offer relief. Stage 3 testing by an international team of researchers led by Belgian gastroenterologist Jan Tack (University Hospitals Leuven) confirms the drug's efficacy.

Naloxegol is based on the same active molecule as naloxone, a drug developed in the 1960s to counter the effects of opioid overdose. Naloxone is commonly used to wake patients from opioid-induced anesthesia after surgery.

To arrive at naloxegol, the researchers modified the molecular structure of naloxone. The result is an orally administered, once-a-day pill for patients experienc
'/>"/>

Contact: Jan Tack
jan.tack@med.kuleuven.be
321-634-4225
KU Leuven
Source:Eurekalert

Page: 1 2

Related medicine news :

1. New therapy for pancreatic cancer patients shows promising results
2. Immune therapy for advanced bladder cancer yields promising results
3. Experimental trial represents promising step toward universal antidote for snakebite
4. Sleep researchers at SRI International identify promising new treatment for narcolepsy
5. Researchers present findings on promising biomarker for esophageal cancer
6. Vibrating capsule shows promising results in treating chronic constipation
7. Danish nasal filter looks promising for allergy sufferers
8. Scientists explore promising new option for first line of attack in lymphoma
9. GW researcher finds gene therapy a promising tool for cardiac regeneration
10. NUS researchers make new discovery of protein as a promising target for treatment of ATC
11. LA BioMed researchers report on promising new therapy for devastating genetic disorder
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/23/2014)... (PRWEB) November 23, 2014 Nearly ... heart attacks, strokes, deep vein thrombosis and other ... a federal multidistrict litigation (MDL) underway in the ... , Court documents updated on November 17th ... (JPML) show the filing of 259 lawsuits against ...
(Date:11/23/2014)... holidays can be a challenge for families of children ... an expert says. "Holidays with family can be ... have children with special needs, some care must be ... of the Sciences in Philadelphia, said in a university ... or visitors know what special requirements are needed to ...
(Date:11/23/2014)... (PRWEB) November 23, 2014 This ... such as its significance, programs and manufacturing technological ... Chinese suppliers major market gamers in information. In ... item specifications, prospective, manufacturing value, and 2009-2014 market ... the evaluation symbolizes the globally and Chinese suppliers ...
(Date:11/23/2014)... 2014 SWAccessControl.com's high quality access control ... the company has announced its new collection of power ... these high quality power suppliers. All the new models ... special offer lasts until Dec. 20, 2014. , SWAccessControl.com ... have been supporting it for a long time. It ...
(Date:11/23/2014)... AngelWeddingDress.com has recently updated its online store, offering ... “If you are looking for gorgeous beach wedding dresses ... Here you can enjoy 70% off discounts and all ... big marriage ceremony is the most important dream of ... is uppermost priority. Ophelia, one of customers, said, “I ...
Breaking Medicine News(10 mins):Health News:Testosterone Lawsuits Approach 260 in Illinois Federal Court Litigation, Bernstein Liebhard LLP Reports 2Health News:Testosterone Lawsuits Approach 260 in Illinois Federal Court Litigation, Bernstein Liebhard LLP Reports 3Health News:Holidays Can Be Sensory Overload for Kids With Autism 2Health News:Femoral Stems Industry 2014 Analysis & 2019 Forecasts for Global and Chinese Region in New Research Report at ReportsnReports.com 2Health News:Femoral Stems Industry 2014 Analysis & 2019 Forecasts for Global and Chinese Region in New Research Report at ReportsnReports.com 3Health News:Femoral Stems Industry 2014 Analysis & 2019 Forecasts for Global and Chinese Region in New Research Report at ReportsnReports.com 4Health News:Cheap Access Control Power Supplies Online Now at SWAccessControl.com, Special Offer Until Dec. 20, 2014 2Health News:Beach Wedding Dresses Added to Outstanding Online Dress Company AngelWeddingDress.com 2
... 17, 2008 A new study in the Review ... meals at restaurants. Results show that both are larger and ... typical fast food meal being smaller and having fewer calories ... , James K. Binkley of Purdue University used data from ...
... , WASHINGTON, Dec. 17 ... A Call for Action: Enabling Healthcare Reform Using Information ... for the Obama Administration and 111th Congress to harness IT,s ... , "President-elect Obama and U.S. ...
... (SDSU) and the Moores Cancer Center at the University ... forces to help explain and eliminate cancer disparities. The ... Institute (NCI) of the National Institutes of Health will ... San Diego region with the goal of reducing differences ...
... 2008 - Elsevier, world-leading publisher of scientific, technical, and ... that, beginning in January 2009, the internationally respected ... ) (http://www.jpsmjournal.com) will be the official journal of the ... The JPSM will continue to serve as ...
... Therapeutics (Prime), a,nationwide pharmacy benefit management (PBM) company, ... as Chief Marketing Officer,(CMO). , ... , As ... marketing,strategy, product development and other market-related initiatives. He ...
... Frank, a medical doctor and,researcher at the University of ... remedy sickness and save lives should have access to the,best ... located near,research institutions in wealthy countries. , ... Frank,s idea led her to ...
Cached Medicine News:Health News:HIMSS Releases Health IT Blueprint for Obama Administration and Congress 2Health News:HIMSS Releases Health IT Blueprint for Obama Administration and Congress 3Health News:HIMSS Releases Health IT Blueprint for Obama Administration and Congress 4Health News:$15 million grant awarded to reduce cancer disparities 2Health News:$15 million grant awarded to reduce cancer disparities 3Health News:$15 million grant awarded to reduce cancer disparities 4Health News:Elsevier announces new partnership between the Journal of Pain and Symptom Management and the AAHPM 2Health News:Prime Therapeutics Hires Steven Blumenfield as Chief Marketing Officer 2Health News:Vivisimo Search Delivers Medical Knowledge to Global Health-Care Community 2
(Date:11/24/2014)... 2014 Luoxis Diagnostics, Inc., a subsidiary ... announced the presentation of three clinical and preclinical ... broadly applicable and robust research tool capable of ... response to injury, illness, or stress.  In all ... Luoxis, academic and pharmaceutical research partners, RedoxSYS was ...
(Date:11/24/2014)... 24, 2014 The Female Health Company (NASDAQ-CM: ... conference call to discuss its operating results for the ... on Tuesday, December 2, 2014 at 11:00 a.m. Eastern ... operating results earlier the same day. Shareholders ... call by dialing 1-877-374-8416 (international participants dial 1-412-317-6716) and ...
(Date:11/24/2014)... DIEGO , Nov. 24, 2014  GlySens Incorporated ... two million dollar grant from the National Institute of ... of the National Institutes of Health (NIH).  The grant ... GlySens second generation ICGM™ long term implantable glucose monitoring ... underway, and enrollment is expected to begin before the ...
Breaking Medicine Technology:Luoxis Announces Presentation of Multiple Studies Validating RedoxSYS as a Rapid and Non-invasive Means of Assessing Oxidative Stress 2Luoxis Announces Presentation of Multiple Studies Validating RedoxSYS as a Rapid and Non-invasive Means of Assessing Oxidative Stress 3Luoxis Announces Presentation of Multiple Studies Validating RedoxSYS as a Rapid and Non-invasive Means of Assessing Oxidative Stress 4Luoxis Announces Presentation of Multiple Studies Validating RedoxSYS as a Rapid and Non-invasive Means of Assessing Oxidative Stress 5The Female Health Company To Report FY2014 Operating Results on Tuesday, December 2, 2014 2GlySens Incorporated Awarded $2 Million Grant from the National Institutes of Health 2
... Pre-Clinical Results Demonstrate Potential of ONCONASE for,Treatment ... /PRNewswire-FirstCall/ --,Alfacell Corporation today announced that new ... is active against naive and,chemoresistant neuroblastoma cells. ... vivo data published in Cancer,Letters (2007; Vol. ...
... WIRE)--Jun 27, 2007 - Opexa,Therapeutics, Inc. (NASDAQ:OPXA), ... of cell therapies, presented,poster presentations at the ... Meeting (ISSCR) in Cairns, Queensland, Australia,from June ... of the International,Society for Cellular Therapy (ISCT) ...
Cached Medicine Technology:In Vitro and In Vivo Data Show Alfacell's Onocanse is Active,Against Naive and Chemoresistant Neuroblastoma Cells 2In Vitro and In Vivo Data Show Alfacell's Onocanse is Active,Against Naive and Chemoresistant Neuroblastoma Cells 3Opexa Advances Monocyte Derived Islet Technology to Proof of,Principle in stz-induced NOD/SCID Mice 2Opexa Advances Monocyte Derived Islet Technology to Proof of,Principle in stz-induced NOD/SCID Mice 3
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... is a national reference laboratory and a ... development. ARUP offers an extensive test menu ... in clinical and anatomic pathology. Owned by ... include more than half of the nation's ...
... reference laboratory and a worldwide leader in ... an extensive test menu of highly complex ... anatomic pathology. Owned by the University of ... half of the nation's university teaching hospitals ...
... national reference laboratory and a worldwide leader ... offers an extensive test menu of highly ... and anatomic pathology. Owned by the University ... than half of the nation's university teaching ...
Medicine Products: