Navigation Links
Promising breakthrough for transplant patients
Date:2/27/2013

This press release is available in French.

A team led by Dr. Marie-Jose Hbert from the University of Montreal Hospital* Research Centre (CRCHUM) has discovered a new cause of organ rejection in some kidney transplant patients. Her team has identified a new class of antibodies anti-LG3 which when activated lead to severe rejection episodes associated with a high rate of organ loss. This discovery, which holds promise for organ recipients, was published in the online version of the American Journal of Transplantation.

Rejection is one of the major obstacles to organ transplantation. For the most part, it occurs when the recipient's immune system recognizes the transplanted organ as a foreign body that must be eliminated. However, even when there is a good donor-recipient immunologic match, the recipient's immune system can attack the transplanted organ's blood vessels. Called acute vascular rejection, this phenomenon often leads to a high rate of graft loss.

Hbert's team has characterized anti-LG3, an antibody that some patients produce to attack LG3, a protein that plays an important role in vascular repair and regeneration. "In these patients, the secretion of LG3 by the new kidney stimulates the activity of these antibodies which attack and injure the blood vessels of the transplanted organ. The net effect is that the normal healing process of the transplanted organ is hindered, if not interrupted, leading to impaired kidney function and even loss," explains Dr. Hbert.

By identifying the heightened presence of anti-LG3 antibodies in patients prior to transplantation, researchers will be able to predict the development of severe rejection episodes. "These results are quite exciting," notes Hbert, "and suggest that new therapies aimed at eliminating LG3 antibodies prior to transplantation could reduce organ rejection or
'/>"/>

Contact: Lucie Dufresne
lucie.dufresne.chum@ssss.gouv.qc.ca
514-890-8000 x15380
Centre hospitalier de l'Universit de Montral
Source:Eurekalert

Page: 1 2

Related medicine news :

1. STARK TRAINING Prepares Promising Future Players For NFL Scouting Combine
2. Scientists find promising new approach to preventing progression of breast cancer
3. NIH scientists discover promising target to block Staphylococcus infection
4. Researchers discover promising prognostic marker for aggressive breast cancer
5. Development of the first way to make large amounts of promising anti-cancer substance
6. Researchers find model system to study promising cancer drug
7. A promising clinical trial to reduce the severity of autistic disorders
8. Treating cocaine dependence: A promising new pharmacotherapy
9. Mayo Clinic identifies promising treatment for inherited form of kidney disease
10. Meth vaccine shows promising results in early tests
11. New developments reveal a molecule with a promising function in terms of cancer treatment.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/20/2014)... 2014 On September 7th, 2014 Peoria will ... connects people living with MS with people who care. This ... are 85% of the way to their goal. This years ... at 11:30 and the walk starts at 1:00 pm. ... answer question about chiropractic care and how it helps symptoms ...
(Date:8/20/2014)... Medical Alert Systems, http://www.medicalalert-systems.com/ , a ... of the most popular medical alert devices including Medical ... it is now offering special deals and discounts on ... a fixed income but would like to purchase some ... welcome news. , As a company spokesperson for the ...
(Date:8/20/2014)... Recently, UWDress.com, the distinguished wedding dress manufacturer and retailer, ... dresses for girls . According to the company’s marketing ... by experienced specialists. Now, they are provided with discounted ... new items come in various styles: A-line scalloped edge ... elegant backless gowns and so on. It is working ...
(Date:8/20/2014)... Park Avenue Dental, a leading Florida-based ... a top graduate of the University of Detroit School ... its website through an ultra-informative blog focused on dental ... parkavenuedentalfl.com, the blog page is chock full of topics ... instead concentrating on important dental care tips ...
(Date:8/20/2014)... Locating rates for insurance packages will now be an ... new source of term life insurance providers has been added ... 50 states at http://quotespros.com/life-insurance.html . , The database ... available for the public to find out the exact annual ... quotations that are available are good through the rest of ...
Breaking Medicine News(10 mins):Health News:Dr. Kelch of AlignLife North Peoria Supports Peoria Annual Walk MS 2Health News:Medical Alert Systems Website Now Offering Special Prices on the Popular Medical Guardian Product 2Health News:Medical Alert Systems Website Now Offering Special Prices on the Popular Medical Guardian Product 3Health News:Cheap Birthday Party Dresses for Girls Now Available at UWDress.com 2Health News:Park Avenue Dental Provides Dental Care Tips for World Wide Community on New Website Blog 2Health News:Park Avenue Dental Provides Dental Care Tips for World Wide Community on New Website Blog 3Health News:Term Life Insurance Price Database Now Helps Quote Prices for Adults in 50 States Online 2
... SAN FRANCISCO (February 11, 2011) In a study ... Medicine,s (SMFM) annual meeting, The Pregnancy Meeting , in ... use of non alcohol antibacterial mouth-rinse containing cetylpyridinium chloride ... "This research demonstrated that reducing the severity of periodontal ...
... have a neat trick they sometimes use to compensate ... made by ground-based telescopes. They create an artificial star ... compensate for the atmospheric turbulence. Lihong Wang, ... Engineering at Washington University in St. Louis, has invented ...
... Bing Energy Inc. of Chino, Calif., has selected Tallahassee as ... in collaboration with Professor Jim P. Zheng of The Florida ... FSU into a better, faster, more economical and commercially viable ... 244 jobs paying an average wage of $41,655 in Florida. ...
... HealthDay Reporter , THURSDAY, Feb. 10 (HealthDay ... clot-busting drug within the recommended 60-minute window after their ... widely recommended that the ,door-to-needle, time should be 60 ... a professor of cardiovascular medicine at the University of ...
... In a study to be presented today at the Society ... in San Francisco, researchers will present findings that show that ... streptococcus (GBS) between their routine third trimester screening and a ... early-onset sepsis is a leading cause of neonatal infection. GBS ...
... Reporter , THURSDAY, Feb. 10 (HealthDay News) -- While ... also hold true: More than one-quarter of married Americans ... has strengthened their union. University of Virginia researchers ... for 29 percent of the people surveyed. Among those ...
Cached Medicine News:Health News:Use of alcohol-free antibacterial mouth-rinse is associated with decrease in preterm birth 2Health News:A guide star lets scientists see deep into human tissue 2Health News:A guide star lets scientists see deep into human tissue 3Health News:A guide star lets scientists see deep into human tissue 4Health News:A guide star lets scientists see deep into human tissue 5Health News:A guide star lets scientists see deep into human tissue 6Health News:Bing Energy relocates to partner with FSU on high-tech fuel cells 2Health News:Bing Energy relocates to partner with FSU on high-tech fuel cells 3Health News:Few Stroke Patients Given Clot-Buster Quickly Enough: Study 2Health News:Few Stroke Patients Given Clot-Buster Quickly Enough: Study 3Health News:Third trimester group B streptococcus test doesn't accurately predict presence during labor 2Health News:Recession Strengthens Some Marriages: Survey 2Health News:Recession Strengthens Some Marriages: Survey 3
(Date:8/20/2014)... Aug. 20, 2014 Reportlinker.com announces ... available in its catalogue: Wireless ... RFID, Zigbee, UWB WWAN, WMAN, WLAN and ... Kalorama Information,s Wireless Opportunities ... Zigbee, UWB WWAN, WMAN, WLAN and other ...
(Date:8/20/2014)... , Aug. 20, 2014 Reportlinker.com announces ... in its catalogue: Global Coatings for ... This report analyzes the ... US$ Million by the following Product Segments: Active ... The report provides separate comprehensive analytics for the ...
(Date:8/20/2014)... LYNDHURST, N.J. , Aug. 20, 2014  Amerigen ... Amerigen Pharmaceuticals Co. Ltd., has received Chinese FDA ... Mecobalamin 0.5 mg Tablets into the ... of a marketing and distribution agreement with Sinochem ... product at its US FDA approved and China ...
Breaking Medicine Technology:Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 2Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 3Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 4Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 5Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 6Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 7Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 8Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 9Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 10Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 11Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 12Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 13Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 14Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 15Wireless Opportunities in Healthcare (The Market for Bluetooth, RFID, Zigbee, UWB WWAN, WMAN, WLAN and other technologies) 16Global Coatings for Medical Devices Industry 2Global Coatings for Medical Devices Industry 3Global Coatings for Medical Devices Industry 4Global Coatings for Medical Devices Industry 5Global Coatings for Medical Devices Industry 6Global Coatings for Medical Devices Industry 7Global Coatings for Medical Devices Industry 8Global Coatings for Medical Devices Industry 9Global Coatings for Medical Devices Industry 10Global Coatings for Medical Devices Industry 11Global Coatings for Medical Devices Industry 12Global Coatings for Medical Devices Industry 13Global Coatings for Medical Devices Industry 14Global Coatings for Medical Devices Industry 15Global Coatings for Medical Devices Industry 16Global Coatings for Medical Devices Industry 17Global Coatings for Medical Devices Industry 18Global Coatings for Medical Devices Industry 19Global Coatings for Medical Devices Industry 20Global Coatings for Medical Devices Industry 21
... 27, 2011 Aethlon Medical, Inc. (OTCBB: AEMD), ... address infectious disease and cancer, disclosed today that ... "A Medical Device Strategy To Inhibit HER2+ Breast ... the company,s website at: http://www.aethlonmedical.com/assets/001/5080.pdf ...
... Sept. 27, 2011 BD Biosciences, a segment of ... of the new BD Falcon™ Multi-Flask, a multi-layer cell ... cell culture easily and more efficiently. ... flasks. The new BD Falcon Multi-Flask, available in both ...
Cached Medicine Technology:"A Medical Device Strategy To Inhibit HER2+ Breast Cancer Progression" Released by Aethlon Medical, Inc. 2"A Medical Device Strategy To Inhibit HER2+ Breast Cancer Progression" Released by Aethlon Medical, Inc. 3BD Biosciences Introduces New Device Designed to Increase Cell Growth and Cell Culture Productivity 2
The new ProteomeX Workstation enables the rapid set up, execution and analysis of multidimensional LC/MS methods, providing you with the best possible technique to characterize your complex proteomic...
... The ProteomeLab XL-A/XL-I functions over a ... strength and pH, delivering more thorough ... operating methodology measures the relative change ... providing an efficient way to measure ...
Storage temperature: 2 - 8C, linearity: 0 - 700 mg/dL, expected values: 30 - 780 mg/dL. Available with calibrator and number of tests 110....
Intended for the quantitative determination of triglycerides in serum or plasma. Reaction: endpoint, reaction is complete in five minutes at 37C. Wavelength: 540 nm. Linearity: 1000 mg/dL (11.3 mmol/...
Medicine Products: