Navigation Links
Promising breakthrough for transplant patients
Date:2/27/2013

This press release is available in French.

A team led by Dr. Marie-Jose Hbert from the University of Montreal Hospital* Research Centre (CRCHUM) has discovered a new cause of organ rejection in some kidney transplant patients. Her team has identified a new class of antibodies anti-LG3 which when activated lead to severe rejection episodes associated with a high rate of organ loss. This discovery, which holds promise for organ recipients, was published in the online version of the American Journal of Transplantation.

Rejection is one of the major obstacles to organ transplantation. For the most part, it occurs when the recipient's immune system recognizes the transplanted organ as a foreign body that must be eliminated. However, even when there is a good donor-recipient immunologic match, the recipient's immune system can attack the transplanted organ's blood vessels. Called acute vascular rejection, this phenomenon often leads to a high rate of graft loss.

Hbert's team has characterized anti-LG3, an antibody that some patients produce to attack LG3, a protein that plays an important role in vascular repair and regeneration. "In these patients, the secretion of LG3 by the new kidney stimulates the activity of these antibodies which attack and injure the blood vessels of the transplanted organ. The net effect is that the normal healing process of the transplanted organ is hindered, if not interrupted, leading to impaired kidney function and even loss," explains Dr. Hbert.

By identifying the heightened presence of anti-LG3 antibodies in patients prior to transplantation, researchers will be able to predict the development of severe rejection episodes. "These results are quite exciting," notes Hbert, "and suggest that new therapies aimed at eliminating LG3 antibodies prior to transplantation could reduce organ rejection or
'/>"/>

Contact: Lucie Dufresne
lucie.dufresne.chum@ssss.gouv.qc.ca
514-890-8000 x15380
Centre hospitalier de l'Universit de Montral
Source:Eurekalert

Page: 1 2

Related medicine news :

1. STARK TRAINING Prepares Promising Future Players For NFL Scouting Combine
2. Scientists find promising new approach to preventing progression of breast cancer
3. NIH scientists discover promising target to block Staphylococcus infection
4. Researchers discover promising prognostic marker for aggressive breast cancer
5. Development of the first way to make large amounts of promising anti-cancer substance
6. Researchers find model system to study promising cancer drug
7. A promising clinical trial to reduce the severity of autistic disorders
8. Treating cocaine dependence: A promising new pharmacotherapy
9. Mayo Clinic identifies promising treatment for inherited form of kidney disease
10. Meth vaccine shows promising results in early tests
11. New developments reveal a molecule with a promising function in terms of cancer treatment.
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/1/2014)... at the University of California, San Diego School of ... in chili peppers produces chronic activation of a ... a reaction that ultimately reduces the risk of colorectal ... 1, 2014 issue of The Journal of Clinical ... TRPV1, was originally discovered in sensory neurons, where it ...
(Date:8/1/2014)... brain plays a central role in regulating appetite and ... in the brain,s control of food intake and body ... process has been unclear. A new study ... that PPARγ activity in a type of neuron known ... response to high-fat diet. Sabrina Diano and colleagues ...
(Date:8/1/2014)... HealthDay Reporter FRIDAY, Aug. 1, 2014 (HealthDay News) ... have significantly less endurance than those who weigh less, a new ... were obese, half were of normal weight -- people who were ... Obesity also was associated with less strength, increased discomfort and ... to 65 years of age -- neither improved nor reduced a ...
(Date:8/1/2014)... -- The U.S. Food and Drug Administration announced on ... help fight type 2 diabetes. Jardiance (empagliflozin) ... regimens to control blood sugar levels in the overall ... Office of Drug Evaluation II in the FDA,s Center ... statement. The FDA also recommended that Jardiance be ...
(Date:8/1/2014)... study, researchers at University Hospitals Rainbow Babies & Children,s ... at greater risk for death on a commercial airline ... worldwide between January 2010 and June 2013 and found ... age of 2. , The study was conducted ... of an in-flight pediatric fatality onboard commercial airline flights ...
Breaking Medicine News(10 mins):Health News:Pepper and halt: Spicy chemical may inhibit gut tumors 2Health News:Obesity Might Slow You Down at Work 2Health News:Obesity Might Slow You Down at Work 3Health News:FDA Approves New Type 2 Diabetes Drug 2Health News:New research characterizes in-flight pediatric deaths 2
... Mayo is the first organization approved for three specialties ... The American Board of Family Medicine (ABFM), ... American Board of Pediatrics (ABP)—the nation,s three largest physician certifying ... Sponsor of Maintenance of Certification (MOC) activities. Mayo Clinic,s rigorous attention ...
... , SAN DIEGO , Jan. 27 ... that the Company will report its fourth quarter and year-end 2009 ... 2010.  Neurocrine will then host a  live conference call and webcast ... afternoon, February 3, 2010 at 5:00 p.m. Eastern ...
... a leading source of adult stem cells, which are ... the cells is an arduous and often painful process. ... as adipose tissue, may be a promising new source ... and progenitor cells (HSPCs), according to a study ...
... United States has an inefficient and expensive health care system, ... care system detailed in a new study in the ... No. 2). According to the authors of ... Health Care System" from Ben-Gurion University of the Negev (BGU) ...
... of Medicine has been awarded six Department of ... grants for innovative medical research. The grants, totaling ... field of breast cancer. Case Western ... awards and three Idea Awards. The three postdoctoral ...
... few anti-spasticity medications used for children with cerebral palsy ... according to a new review of scientific literature headed ... by a national panel of interdisciplinary experts nationwide. ... release a new practice guideline on effective treatments. Dr. ...
Cached Medicine News:Health News:Mayo Clinic Recognized by Three Certifying Boards for Quality Improvement Activities 2Health News:Mayo Clinic Recognized by Three Certifying Boards for Quality Improvement Activities 3Health News:Mayo Clinic Recognized by Three Certifying Boards for Quality Improvement Activities 4Health News:Mayo Clinic Recognized by Three Certifying Boards for Quality Improvement Activities 5Health News:Neurocrine Biosciences Announces Conference Call and Webcast to Present Fourth Quarter and Year-End 2009 Financial Results 2Health News:Fat tissue may be a source of valuable blood stem cells, study says 2Health News:Fat tissue may be a source of valuable blood stem cells, study says 3Health News:Integrating private insurance with public health would improve US health care -- study 2Health News:Case Western Reserve receives $2.8 million to further breast cancer research 2Health News:Anti-spasticity medications need further research 2
(Date:7/31/2014)... Pa. , July 31, 2014   Auxilium ... fully integrated specialty biopharmaceutical company, today announced that the ... 2014 on Thursday, August 7, 2014 before the opening ... conduct a conference call that day at 8:30 a.m. ... quarter of 2014. The presentation slides to be used ...
(Date:7/31/2014)... Fla. , July 31, 2014 Rock ... today that it has initiated the development of its ... ; and that it has selected Quotient Clinical, The ... Kingdom (UK) to run its early development ... Clinical Trial Application (CTA) by the end of the ...
(Date:7/31/2014)... 2014  Decision Resources Group is launching an extension ... to now include ChinaTrack; the new capabilities track the ... interactive dashboard providing detailed brand-level share tracking and analytics. ... level. Other key capabilities of the new ... addition to end-user surveys of healthcare facilities, ChinaTrack data ...
Breaking Medicine Technology:Auxilium Pharmaceuticals, Inc. To Announce Second Quarter 2014 Results On August 7, 2014 2Auxilium Pharmaceuticals, Inc. To Announce Second Quarter 2014 Results On August 7, 2014 3Rock Creek Pharmaceuticals Provides Update of its European Drug Development Regulatory Strategy and selects Quotient Clinical for its early development programs 2Rock Creek Pharmaceuticals Provides Update of its European Drug Development Regulatory Strategy and selects Quotient Clinical for its early development programs 3Rock Creek Pharmaceuticals Provides Update of its European Drug Development Regulatory Strategy and selects Quotient Clinical for its early development programs 4Decision Resources Group Announces First Medical Device Account Targeting Tool in China 2
... 13 Eli Lilly and Company (NYSE: LLY ... vice president, science and technology, and president, Lilly Research ... Lilly has also announced that Jan M. Lundberg, Ph.D., ... AstraZeneca, is to become his successor. Paul is committed ...
... Millar Instruments, Inc. developer and manufacturer of Mikro-Tip® ... Harvard Apparatus, manufacturer of specialty life science equipment, ... DiGiusto, President of Harvard Apparatus states, "We are ... Instruments to provide comprehensive solutions for physiology research. ...
Cached Medicine Technology:Dr. Steven M. Paul to Retire from Lilly as Executive Vice President, Science and Technology, President, Lilly Research Laboratories; Dr. Jan M. Lundberg, Executive Vice President, Head of Global Discovery Research, AstraZeneca, Named his Successor 2Dr. Steven M. Paul to Retire from Lilly as Executive Vice President, Science and Technology, President, Lilly Research Laboratories; Dr. Jan M. Lundberg, Executive Vice President, Head of Global Discovery Research, AstraZeneca, Named his Successor 3Millar Instruments and Harvard Apparatus Improve Ability to Provide Customers With Total Physiology Solutions Through Joint Distribution Agreement 2
Stainless steel bone clamp....
Designed for proximal femoral elevation in total hip replacement or in other surgery with a similar need for bone manipulation....
To elevate, dissect, scrape and apply traction to bone and soft tissue....
The AV Plus DX pacing lead is designed for use with the St. Jude Medical Affinity VDR pulse generator. This single-lead pacing system provides reliable pacing therapy with the added benefits of AV sy...
Medicine Products: