Navigation Links
Promising and perilous? The ambivalent role of the CXCL12/ CXCR4 axis in heart repair
Date:11/30/2011

The chemokine CXCL12 acts as a chemical signal which mobilizes hematopoietic and other types of stem cells to leave the bone marrow and enter the circulation. Secretion of CXCL12 also guides these cells to sites at which the perfusion of tissue is sub-optimal due to localized obstruction of blood flow. These capabilities have made CXCL12 and its cognate receptor CXCR4 interesting candidates for therapies aimed at mitigating the effects of damage to the heart caused by myocardial infarction.

A team of researchers led by Professor Christian Weber of the Medical Center of the University of Munich has now taken a closer look at the normal physiological function of this ligand-receptor couple. Their results reveal that the molecules have "rather ambivalent roles," as Weber puts it.

Myocardial infarction remains one of the leading causes of death in Western societies. The condition occurs when parts of the heart muscle can no longer be adequately supplied with oxygen because blood flow through the coronary arteries is impeded. Researchers have therefore suggested that CXCL12 and CXCR4 could perhaps be used therapeutically to direct stem cells required for the formation of new blood vessels to migrate into ischemic, i.e. poorly perfused, tissues and thus help to increase blood flow in such areas.

"The precise physiological functions of the chemokine and its receptor are poorly understood, although these are the crucial determinants of their therapeutic potential and of possible side-effects," Weber points out. "We therefore studied the effects of infarction in an animal model in which the amount of CXCR4 produced is specifically reduced. We focused on the molecular and cellular consequences of infarction, particularly with respect to the recovery of cardiac function, formation of scar tissue, severity of inflammation, and neovascularization of heart muscle."

To their surprise the researchers found that reduction of the CXCR4 level correlated with significant reductions in infarct size and the degree of tissue inflammation, but that recovery of blood flow and neovascularization were concomitantly decreased. These opposing effects together meant that heart function was equally impaired whether or not the level of CXCR4 function was reduced.

"However, we did see some evidence for an improvement in adaptation to sub-optimal levels of oxygen," Weber remarks. "Although we cannot assume that these results are immediately applicable to the human heart, they do point toward the possibility especially in the case of systemic therapy of quite critical side-effects. We should perhaps focus on more localized approaches, such as the direct injection of stem cells with higher levels of CXCR4, or of CXCL12 variants that remain confined to the damaged areas of the heart or retain their activity in the coronary arteries for longer." (suwe/PH)


'/>"/>

Contact: Luise Dirscherl
dirscherl@lmu.de
49-892-180-2706
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

Related medicine news :

1. New artemisinin-based treatment against malaria promising
2. New Multiple Sclerosis Therapy Promising in Early Trial
3. Promising Malaria Vaccine May Save Childrens Lives
4. Promising new approach to treating debilitating nervous system disease
5. FDG-PET appears promising for predicting prognosis of patients with inoperable NSCLC
6. New half-match bone marrow transplant procedure yields promising outcomes for cancer patients
7. DOE laboratories help develop promising new cancer fighting drug, vemurafenib
8. Experimental Drug Promising Against Tough-to-Treat Asthma
9. INFORMS: CARE positions disaster relief with promising discipline of humanitarian logistics
10. Massachusetts General Hospital, Iacocca Foundation announce promising results of Phase I diabetes trial
11. Fighting cancer with cancer: Mayo Clinic finds promising use for thyroid cancer gene
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/18/2017)... ... 17, 2017 , ... Park Cities Pet Sitter President, Joette White, has been ... Radio network. The episode, which was posted this week, features a 30-minute interview ... to Park Cities Pet Sitter’s being awarded the 2017 National Association of Professional Pet ...
(Date:2/18/2017)... ... February 18, 2017 , ... A new directory ... contact points to easily connect elderly veterans of America's armed forces to a ... It also conveys material on this year's increase in the Veterans Pension with ...
(Date:2/17/2017)... ... February 17, 2017 , ... While EHR data has ... introduced an innovative workstation designed to reduce nursing fatigue while enhancing productivity. Based ... Workstation offers a lightweight, highly mobile, multi-functional alternative to the limitations of handheld ...
(Date:2/17/2017)... , ... February 17, 2017 , ... ... that allow for the electronic prescribing of controlled and non-controlled substances plus the ... percent of pharmacies in the United States now accept electronic prescriptions, according to ...
(Date:2/17/2017)... Falls Church, VA (PRWEB) , ... ... ... to Integrate FDA Device Approval and Reimbursement , **An FDAnews Webinar**, Feb. ... , What are the critical reimbursement questions manufacturers should be asking ...
Breaking Medicine News(10 mins):
(Date:2/17/2017)... , Feb 17, 2017 Research and Markets has ... Business Report" report to their offering. ... The report provides separate comprehensive analytics for the US, ... , Asia-Pacific , and Rest of World. Annual ... a six-year historic analysis is provided for these markets. Market data and ...
(Date:2/17/2017)... , Feb. 17, 2017   Risperdal lawsuits ... effects allegedly associated with use of the atypical antipsychotic ... Philadelphia Court of Common Pleas, where the ... tort program. According to a notice posted on the ... convene a meeting on March 9, 2017 at 11:00 ...
(Date:2/17/2017)... 17, 2017   FormFast , the leader in ... partnership with Engage , one of the largest ... . FormFast will serve as the forms automation and ... MEDITECH .  FormFast is a ... complement and enhance the electronic health record. FormFast,s technology ...
Breaking Medicine Technology: