Navigation Links
Promising and perilous? The ambivalent role of the CXCL12/ CXCR4 axis in heart repair
Date:11/30/2011

The chemokine CXCL12 acts as a chemical signal which mobilizes hematopoietic and other types of stem cells to leave the bone marrow and enter the circulation. Secretion of CXCL12 also guides these cells to sites at which the perfusion of tissue is sub-optimal due to localized obstruction of blood flow. These capabilities have made CXCL12 and its cognate receptor CXCR4 interesting candidates for therapies aimed at mitigating the effects of damage to the heart caused by myocardial infarction.

A team of researchers led by Professor Christian Weber of the Medical Center of the University of Munich has now taken a closer look at the normal physiological function of this ligand-receptor couple. Their results reveal that the molecules have "rather ambivalent roles," as Weber puts it.

Myocardial infarction remains one of the leading causes of death in Western societies. The condition occurs when parts of the heart muscle can no longer be adequately supplied with oxygen because blood flow through the coronary arteries is impeded. Researchers have therefore suggested that CXCL12 and CXCR4 could perhaps be used therapeutically to direct stem cells required for the formation of new blood vessels to migrate into ischemic, i.e. poorly perfused, tissues and thus help to increase blood flow in such areas.

"The precise physiological functions of the chemokine and its receptor are poorly understood, although these are the crucial determinants of their therapeutic potential and of possible side-effects," Weber points out. "We therefore studied the effects of infarction in an animal model in which the amount of CXCR4 produced is specifically reduced. We focused on the molecular and cellular consequences of infarction, particularly with respect to the recovery of cardiac function, formation of scar tissue, severity of inflammation, and neovascularization of heart muscle."

To their surprise the researchers found that reduction of the CXCR4 level correlated with significant reductions in infarct size and the degree of tissue inflammation, but that recovery of blood flow and neovascularization were concomitantly decreased. These opposing effects together meant that heart function was equally impaired whether or not the level of CXCR4 function was reduced.

"However, we did see some evidence for an improvement in adaptation to sub-optimal levels of oxygen," Weber remarks. "Although we cannot assume that these results are immediately applicable to the human heart, they do point toward the possibility especially in the case of systemic therapy of quite critical side-effects. We should perhaps focus on more localized approaches, such as the direct injection of stem cells with higher levels of CXCR4, or of CXCL12 variants that remain confined to the damaged areas of the heart or retain their activity in the coronary arteries for longer." (suwe/PH)


'/>"/>

Contact: Luise Dirscherl
dirscherl@lmu.de
49-892-180-2706
Ludwig-Maximilians-Universitt Mnchen
Source:Eurekalert

Related medicine news :

1. New artemisinin-based treatment against malaria promising
2. New Multiple Sclerosis Therapy Promising in Early Trial
3. Promising Malaria Vaccine May Save Childrens Lives
4. Promising new approach to treating debilitating nervous system disease
5. FDG-PET appears promising for predicting prognosis of patients with inoperable NSCLC
6. New half-match bone marrow transplant procedure yields promising outcomes for cancer patients
7. DOE laboratories help develop promising new cancer fighting drug, vemurafenib
8. Experimental Drug Promising Against Tough-to-Treat Asthma
9. INFORMS: CARE positions disaster relief with promising discipline of humanitarian logistics
10. Massachusetts General Hospital, Iacocca Foundation announce promising results of Phase I diabetes trial
11. Fighting cancer with cancer: Mayo Clinic finds promising use for thyroid cancer gene
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... D.C. (PRWEB) , ... June 25, 2016 , ... ... discuss health policy issues and applications at AcademyHealth’s Annual Research Meeting June 26-28, ... their work on several important health care topics including advance care planning, healthcare ...
(Date:6/25/2016)... Long Beach, CA (PRWEB) , ... June 25, 2016 , ... ... from UCLA with Magna Cum Laude and his M.D from the David Geffen School ... San Diego and returned to Los Angeles to complete his fellowship in hematology/oncology at ...
(Date:6/24/2016)... ... 2016 , ... Those who have experienced traumatic events may suffer from a ... such as drug or alcohol abuse, as a coping mechanism. To avoid this pain ... following a traumatic event. , Trauma sufferers tend to feel a range of emotions, ...
(Date:6/24/2016)... , ... June 24, 2016 , ... ... offering micro-osteoperforation for accelerated orthodontic treatment. Dr. Cheng has extensive experience with all ... brackets , AcceleDent, and accelerated osteogenic orthodontics. , Micro-osteoperforation is a revolutionary ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute Beauty ... Barry M. Weintraub as a prominent plastic surgeon and the network’s newest partner. ... and the most handsome men, look naturally attractive. Plastic surgery should be invisible.” ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , Belgium , June 24, ... VNRX), today announced the appointment of Dr. ... Directors as a Non-Executive Director, effective June 23, ... Audit, Compensation and Nominations and Governance Committees.  As ... Futcher will provide independent expertise and strategic counsel ...
(Date:6/23/2016)... 23, 2016 Any dentist who has made an ... current process. Many of them do not even offer this ... and high laboratory costs involved. And those who ARE able ... such a high cost that the majority of today,s patients ... Parsa Zadeh , founder of Dental Evolutions Inc. and ...
(Date:6/23/2016)... 23, 2016 Research and Markets has ... Market Analysis 2016 - Forecast to 2022" report to ... report contains up to date financial data derived from varied ... major trends with potential impact on the market during the ... segmentation which comprises of sub markets, regional and country level ...
Breaking Medicine Technology: