Navigation Links
Prolactin blocks oncogene associated with poor prognosis in breast cancer
Date:2/3/2010

(PHILADELPHIA) Researchers from the Kimmel Cancer Center at Jefferson have found a mechanism by which a hormone responsible for milk production blocks an oncogene that makes breast cancer more aggressive.

Publishing in the journal Cancer Research, the researchers discovered that prolactin, a pituitary hormone that normally stimulates breast development and milk production, in fact reduces levels of an oncogene called BCL6. The BCL6 protein has previously been shown to play a role in poorly differentiated breast cancer, which carries a poorer prognosis.

According to Hallgeir Rui, M.D., Ph.D., a professor of Cancer Biology and Medical Oncology at Jefferson Medical College of Thomas Jefferson University, prolactin's role in breast cancer is, to a large extent, carried out by a protein pathway called Stat5. In breast cancer, the inactivation of Stat5 is related to poorly differentiated breast cancer, and thus poorer prognosis.

"We found that prolactin will block expression of the BCL6 protein, and showed that Stat5a, but not the very similar Stat5b variant, is involved in this process as a mediator of prolactin," said Dr. Rui. "We think that prolactin plays an important role in preventing aggressive breast cancers, and that there is a connection between the loss of Stat5 and the increase of BCL6 in making breast cancer more aggressive."

Dr Rui and his laboratory investigated the phenomenon in several different breast cancer cell lines grown in the laboratory, and also in mice and in human breast cancer samples. The relationship held up across all three.

Receptors for prolactin are present on a majority of breast cancers. Prolactin levels in blood are relatively unaffected by menopause, and breast cancer patients across all age groups are exposed to the hormone. The new findings may lead to better diagnostic tests for breast cancer, and also the development of new treatments.


'/>"/>

Contact: Emily Shafer
emily.shafer@jefferson.edu
215-955-6300
Thomas Jefferson University
Source:Eurekalert

Page: 1

Related medicine news :

1. Jefferson researchers uncover new evidence of prolactins possible role in breast cancer
2. Idahos Health Care Woes Need Solutions, Not More Roadblocks
3. Drug Combo Blocks HIV Infection in Mice
4. Undocumented Hispanics Face Health Care Roadblocks in U.S.
5. New chemo cocktail blocks breast cancer like a strong fence
6. U.S. Leadership in Medical Innovation Depends on Education and Immigration Policy, Say Experts at Capitol Hill Briefing on Education & Immigration: Building Blocks of Innovation
7. Council for American Medical Innovation to Host Capitol Hill Breakfast Briefing on Education and Immigration: The Building Blocks of Innovation
8. Federal Judge Orders Schwarzenegger Administration to Comply with Order That Blocks State Reduction for IHSS Worker Wages
9. BurrellesLuce White Paper Gives Advice on Turning Twitter Connections Into Community Building Blocks
10. Iran Blocks Access to the Chopra Center's Web Site, Podcasts, and Blogs
11. Prospect Therapeutics In Vitro Studies Demonstrate that GCS-100 Drug Binds to and Blocks the Effects of Galectin-3
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:10/13/2017)... ... October 13, 2017 , ... “The Journey: From the Mountains to the Mission ... lost souls in the Philippines. “The Journey: From the Mountains to the Mission Field” ... the Bible. She has taught all ages and currently teaches a class of ladies ...
(Date:10/12/2017)... San Francisco, CA (PRWEB) , ... October 12, ... ... and Dr. Cheng, are now treating sleep apnea using cutting-edge Oventus ... sleep apnea, a serious sleep disorder characterized by frequent cessation in breathing. Oral ...
(Date:10/12/2017)... ... October 12, 2017 , ... IsoComforter, Inc. ( https://isocomforter.com ... the introduction of an innovative new design of the shoulder pad. The shoulder ... maximum comfort while controlling your pain while using cold therapy. By utilizing ice and ...
(Date:10/12/2017)... ... 12, 2017 , ... Information about the technology: , Otomagnetics ... enable prevention of a major side effect of chemotherapy in children. Cisplatin and ... For cisplatin, hearing loss is FDA listed on-label as a dose limiting toxicity. ...
(Date:10/12/2017)... ... October 12, 2017 , ... Leading pediatric oncology experts at ... for the 49th Congress of the International Society of Paediatric Oncology (SIOP) ... Center for Cancer and Blood Disorders at Children’s National, and Stephen P. ...
Breaking Medicine News(10 mins):
(Date:10/11/2017)... FRISCO, Texas , Oct. 11, 2017 /PRNewswire/ ... healthcare services, has amplified its effort during National ... patients about hereditary cancer risks. ... Journal of Clinical Oncology calculated that more than ... to have inherited mutations in BRCA1 or BRCA2 and ...
(Date:10/7/2017)... , Oct. 6, 2017   Provista, a ... than $100 billion in purchasing power, today announced a ... information. The Newsroom is the online home ... trends, infographics, expert bios, news releases, slideshows and events. ... to a wealth of resources at their fingertips, viewers ...
(Date:10/4/2017)... , Oct. 4, 2017 ... single-use, self-contained, illuminating medical devices, today announced regulatory ... Health Surveillance Agency (or Agência Nacional de Vigilância ... first single-use, cordless surgical retractor with integrated LED ... optimal access, illumination and exposure of a tissue ...
Breaking Medicine Technology: