Navigation Links
Project Will Map Genomes of 1,000 People Worldwide
Date:1/22/2008

International effort should spot genes that help cause disease, scientists say

TUESDAY, Jan. 22 (HealthDay News) -- The genomes of 1,000 people worldwide will be mapped in what scientists are calling the most detailed and medically relevant look at human genetic variation ever conducted.

As outlined by an international team of researchers on Tuesday, the 1000 Genomes Project will receive major support from the U.S. National Human Genome Research Institute (NHGRI), the Wellcome Trust Sanger Institute in England, and the Beijing Genomics Institute in China.

"The 1000 Genomes Project will examine the human genome at a level of detail that no one has done before," consortium co-chair Richard Durbin, of the Wellcome Trust Sanger Institute, said in a prepared statement.

Data from the project will be made available to the worldwide scientific community through public databases. The people who have their genomes sequenced will remain anonymous and will not have to provide any personal medical information.

Among the populations whose DNA will be sequenced in this effort are: Yoruba in Ibadan, Nigeria; Japanese in Tokyo; Chinese in Beijing; Utah residents with ancestry from northern and western Europe; Luhya in Webuye, Kenya; Maasai in Kinyawa, Kenya; Toscani in Italy; Gujarati Indians in Houston; Chinese in metropolitan Denver; people of Mexican ancestry in Los Angeles; and people of African ancestry in the southwestern United States.

"Such a project would have been unthinkable only two years ago. Today, thanks to amazing strides in sequencing technology, bioinformatics and population genomics, it is now within our grasp," Durbin said. "So we are moving forward to build a tool that will greatly expand and further accelerate efforts to find more of the genetic factors involved in human health and disease."

All humans are more than 99 percent genetically identical. However, understanding the small fraction of genetic variation among humans can help explain individual differences in disease susceptibility, response to drugs, or reaction to environmental factors.

Previous research has identified more than 100 regions of the human genome that contain genetic variants associated with the risk of common diseases such as diabetes, coronary artery disease, prostate and breast cancer, rheumatoid arthritis, inflammatory bowel disease, and age-related macular degeneration.

However, existing genome maps are not extremely detailed, which means that researchers often have to use expensive and time-consuming DNA sequencing to help them identify precise genetic variants that cause a disease.

The new genetic map created by the 1000 Genomes Project will help scientists more quickly pinpoint disease-related genetic variants and advance efforts to use genetic information to develop new ways to diagnose, treat and prevent genetic-related diseases.

"This new project will increase the sensitivity of disease discovery efforts across the genome five-fold and within gene regions at least 10-fold," NHGRI director Dr. Francis S. Collins said in a prepared statement.

"Our existing databases do a reasonably good job of cataloging variations found in at least 10 percent of a population. By harnessing the power of new sequencing technologies and novel computational methods, we hope to give biomedical researchers a genome-wide map of variation down to the 1 percent level. This will change the way we carry out studies of genetic disease," Collins said.

More information

Find out more at 1000 genomes.



-- Robert Preidt



SOURCE: U.S. National Human Genome Research Institute, news release, Jan. 22, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. QI projects may -- or may not -- improve patient safety and outcomes
2. MU researchers to collaborate on $20 million project
3. Fry Construction Selected for High-Profile Medical Imaging Project
4. Jacobs Receives Contract for New Hospital Project in Belgium
5. IVCC launches groundbreaking insecticide projects with Bayer and Syngenta
6. Global Health Project targets reducing AIDS among Indias adolescents
7. Uncontrolled Blood Pressure Highest Among Hispanics, Prompting New Hypertension Project in San Antonio
8. New Business Development of Multi-Hospital Project!
9. ARIZONA METH PROJECT Unveils Arizonas Anti-Meth Youth Pledge and Kicks Off Phase Two of Public Awareness Campaign
10. Meth Project Advertisements Selected for National Prevention Campaign
11. Pillow, PAs Great American Sleep Better(TM)Project Reports Results
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Project Will Map Genomes of 1,000 People Worldwide
(Date:3/24/2017)... ... March 24, 2017 , ... Empower Brokerage, ... their training and leads programs. , In February, 2017, Empower Brokerage introduced their ... Performance Partners is designed to teach how to maximize their sales efforts, as ...
(Date:3/24/2017)... ... March 24, 2017 , ... “Finding Christ Through Social Media: ... journal chronicling the writer’s path toward true communion with God. “Finding Christ Through ... is the creation of published author Lea Michelle Johnson, a follower of Christ, ...
(Date:3/24/2017)... (PRWEB) , ... March 24, 2017 , ... “Vintage and ... a retired minister and college Bible teacher residing in North Carolina with his wife, ... who have blessed them with six grandchildren. David is also the author of “Shadow ...
(Date:3/24/2017)... ... ... “The Adventures of Joey, The Dog Who Barks at Puddles”: a boisterous story ... fullest, as God intended. “The Adventures of Joey, The Dog Who Barks at Puddles” ... passion for writing, especially about truth and human behavior. , Published by Christian Faith ...
(Date:3/23/2017)... ... ... A recent report from the National Council on Teacher Quality (NCTQ) advocates for ... on a review of GPA and SAT/ACT requirements at 221 institutions in 25 states, ... that this higher bar should be set by states, by the Council for the ...
Breaking Medicine News(10 mins):
(Date:3/23/2017)... , Mar 23, 2017 Research and ... Analysis & Trends - Industry Forecast to 2025" report to ... ... of around 6.9% over the next decade to reach approximately $3.5 ... estimates and forecasts for all the given segments on global as ...
(Date:3/23/2017)... , March 23, 2017 The ... ageing population, increasing diabetic population, accelerating economic growth and increasing ... this industry are higher life expectancy of ESRD patients, rising ... emerging markets. However, the expansion of the market is hindered ... ...
(Date:3/23/2017)... , March 23, 2017  Transportation Insight, a multi-modal ... end-to-end supply chain management firm with expertise serving clients ... Solutions Rick Zaffarano was named a 2017 ... Supply Chain by the only publication exclusively dedicated to ... supply chain. "Rick has brought to Transportation ...
Breaking Medicine Technology: