Navigation Links
Project Will Map Genomes of 1,000 People Worldwide
Date:1/22/2008

International effort should spot genes that help cause disease, scientists say

TUESDAY, Jan. 22 (HealthDay News) -- The genomes of 1,000 people worldwide will be mapped in what scientists are calling the most detailed and medically relevant look at human genetic variation ever conducted.

As outlined by an international team of researchers on Tuesday, the 1000 Genomes Project will receive major support from the U.S. National Human Genome Research Institute (NHGRI), the Wellcome Trust Sanger Institute in England, and the Beijing Genomics Institute in China.

"The 1000 Genomes Project will examine the human genome at a level of detail that no one has done before," consortium co-chair Richard Durbin, of the Wellcome Trust Sanger Institute, said in a prepared statement.

Data from the project will be made available to the worldwide scientific community through public databases. The people who have their genomes sequenced will remain anonymous and will not have to provide any personal medical information.

Among the populations whose DNA will be sequenced in this effort are: Yoruba in Ibadan, Nigeria; Japanese in Tokyo; Chinese in Beijing; Utah residents with ancestry from northern and western Europe; Luhya in Webuye, Kenya; Maasai in Kinyawa, Kenya; Toscani in Italy; Gujarati Indians in Houston; Chinese in metropolitan Denver; people of Mexican ancestry in Los Angeles; and people of African ancestry in the southwestern United States.

"Such a project would have been unthinkable only two years ago. Today, thanks to amazing strides in sequencing technology, bioinformatics and population genomics, it is now within our grasp," Durbin said. "So we are moving forward to build a tool that will greatly expand and further accelerate efforts to find more of the genetic factors involved in human health and disease."

All humans are more than 99 percent genetically identical. However, understanding the small fraction of genetic variation among humans can help explain individual differences in disease susceptibility, response to drugs, or reaction to environmental factors.

Previous research has identified more than 100 regions of the human genome that contain genetic variants associated with the risk of common diseases such as diabetes, coronary artery disease, prostate and breast cancer, rheumatoid arthritis, inflammatory bowel disease, and age-related macular degeneration.

However, existing genome maps are not extremely detailed, which means that researchers often have to use expensive and time-consuming DNA sequencing to help them identify precise genetic variants that cause a disease.

The new genetic map created by the 1000 Genomes Project will help scientists more quickly pinpoint disease-related genetic variants and advance efforts to use genetic information to develop new ways to diagnose, treat and prevent genetic-related diseases.

"This new project will increase the sensitivity of disease discovery efforts across the genome five-fold and within gene regions at least 10-fold," NHGRI director Dr. Francis S. Collins said in a prepared statement.

"Our existing databases do a reasonably good job of cataloging variations found in at least 10 percent of a population. By harnessing the power of new sequencing technologies and novel computational methods, we hope to give biomedical researchers a genome-wide map of variation down to the 1 percent level. This will change the way we carry out studies of genetic disease," Collins said.

More information

Find out more at 1000 genomes.



-- Robert Preidt



SOURCE: U.S. National Human Genome Research Institute, news release, Jan. 22, 2008


'/>"/>
Copyright©2008 ScoutNews,LLC.
All rights reserved  

Related medicine news :

1. QI projects may -- or may not -- improve patient safety and outcomes
2. MU researchers to collaborate on $20 million project
3. Fry Construction Selected for High-Profile Medical Imaging Project
4. Jacobs Receives Contract for New Hospital Project in Belgium
5. IVCC launches groundbreaking insecticide projects with Bayer and Syngenta
6. Global Health Project targets reducing AIDS among Indias adolescents
7. Uncontrolled Blood Pressure Highest Among Hispanics, Prompting New Hypertension Project in San Antonio
8. New Business Development of Multi-Hospital Project!
9. ARIZONA METH PROJECT Unveils Arizonas Anti-Meth Youth Pledge and Kicks Off Phase Two of Public Awareness Campaign
10. Meth Project Advertisements Selected for National Prevention Campaign
11. Pillow, PAs Great American Sleep Better(TM)Project Reports Results
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Project Will Map Genomes of 1,000 People Worldwide
(Date:4/25/2017)... Vegas, NV (PRWEB) , ... April 25, 2017 ... ... can now choose a modern procedure that achieves results in a fraction of ... in Las Vegas, NV, with Significance Dental Specialists, now offers this revolutionary ...
(Date:4/25/2017)... ... , ... Back Pain Centers of America (BPC), which connects people ... their area, announces the launch of a new and proprietary customer relationship management (CRM) ... reputable physicians to help them with back or neck pain and helps to match ...
(Date:4/25/2017)... ... April 25, 2017 , ... ... predictive analytics to its patient care management module. Using this new feature, sleep ... patient has been initiated on continuous positive airway pressure (CPAP), oral, or other ...
(Date:4/25/2017)... ... April 25, 2017 , ... Vetoquinol USA® , a ... UCII, part of the EQUISTRO line, at this week’s Rolex Kentucky Three-Day Event ... the immunologic level. , The scientifically-developed Flexadin UCII supports the body’s normal repair ...
(Date:4/24/2017)... ... April 24, 2017 , ... LG CNS Healthcare ... Device (BYOD) capabilities at Telehealth 2.0, the American Telemedicine Association’s national conference. , ... medical devices with a pre-programmed tablet in a remarkably easy-to-use kit for patients. ...
Breaking Medicine News(10 mins):
(Date:4/19/2017)... , April 19, 2017  Vanderbilt University Medical Center ... in Nashville , Tennesse have been ... Sphincter Stimulation for GERD (LESS GERD) trial. The EndoStim ... long-term reflux control by restoring normal function to the ... million people in the United States ...
(Date:4/19/2017)... N.J. , April 19, 2017  Novartis ... by the National Heart, Lung, and Blood Institute ... demonstrating that 58% of patients with treatment-naïve severe ... months when treated with eltrombopag at the initiation ... . The study evaluated three sequential treatment groups, ...
(Date:4/18/2017)... April 18, 2017 Research and Markets has ... report to their offering. ... The global arthroscopy devices market to grow at a CAGR of ... Arthroscopy Devices Market 2017-2021, has been prepared based on an in-depth ... market landscape and its growth prospects over the coming years. The ...
Breaking Medicine Technology: