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Project Achilles pinpoints vulnerabilities in ovarian cancer
Date:7/11/2011

s is considered.

"A traditional way of doing these experiments was to compare one cell line versus another cell line," said Hahn. "When you test that, it turns out that's not a very robust way of doing things. What we show in this paper is that if you have eight or nine cell lines that you're comparing against each other, then your confidence in the candidates that emerge increases."

In the coming months, Hahn and his team plan to pursue the PAX8 result. Although the gene encodes a transcription factor, a class of master control proteins that have been pessimistically labeled "undruggable," the researchers will team up with the Broad's Chemical Biology Platform to look through hundreds of thousands of unique compounds to find one that can neutralize PAX8. "PAX8 is a transcription factor and it's considered a difficult or impossible target to make drugs against, but that's exactly the kind of project that the Broad likes to take on," said Hahn.

Meanwhile, the Hahn lab, RNAi Platform, and other Broad investigators are further pursuing the Project Achilles strategy, screening many more cell lines and devising new analysis methods to nominate promising target genes in many different types of cancer.


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Contact: Nicole Davis
ndavis@broadinstitute.org
617-714-7152
Broad Institute of MIT and Harvard
Source:Eurekalert

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