Navigation Links
Project Achilles pinpoints vulnerabilities in ovarian cancer
Date:7/11/2011

s which of those are important functionally," he said.

The team used a pool of more than 54,000 shRNAs from the library developed by the Broad's RNAi Platform. "The methods that we have developed in the RNAi Platform make it practical and relatively inexpensive to screen shRNAs at a genomic scale and our first area of application was in cancer research," said David Root, director of the RNAi Platform. "The scale-up to the 100 cell lines reported in this most recent paper was a big challenge, but we also saw a huge opportunity. With data on many more cell lines, we would have far, far greater power to identify functionally important cancer targets."

The latest Project Achilles research also addresses a fundamental question in cancer biology. For decades, cancer has been classified based on tissue of origin, but within the last ten years, many scientists have suggested that it may be more revealing to classify tumors based on genetic mutations, regardless of where the cancer first began.

"Many of us in the genomics field including myself were thinking that maybe someday, we won't care about the organs that cancers come from, that we will only care about the genetic mutations that drive them," said Hahn. "What's emerging from TCGA and our Project Achilles work is that lineage will continue to be important."

Hahn suspects that in some cases, this may have to do with the way that different organ systems develop. One of the top genes that the Project Achilles team detected in ovarian cancer cells is PAX8, which plays an important role in the development of the female reproductive system. They found too many copies of PAX8 in 16 percent of the ovarian cancers they examined. In cell lines where PAX8 was overexpressed, suppressing PAX8 led to cell death.

In addition to their findings in ovarian cancer, the researchers found that looking across cancer types can reveal cancer-causing genes, but only if a large number of sample
'/>"/>

Contact: Nicole Davis
ndavis@broadinstitute.org
617-714-7152
Broad Institute of MIT and Harvard
Source:Eurekalert

Page: 1 2 3

Related medicine news :

1. International Diabetes Federation awards $2 million to 9 global diabetes research projects
2. Wingman Project Implemented for Deep Freeze Mission
3. San Diego State University and BIOCOM Institute Receive $4.95 Million Grant: The BRIDGE Project, Linking Education to Employment in San Diegos Life Sciences Industry
4. Partners Home Care Scores in Top Tier in National Medicare Demonstration Project
5. State of Oregon Department of Human Services Selects Netsmart Technologies for Comprehensive Behavioral Healthcare Integration Project
6. Project Runways Tim Gunn Returns to Address Psoriasis(TM) and Empower Patients to be Confident in Their Personal Style
7. Project Prevention Brings Controversial Sterilization Program to Honolulu
8. Good Vibrations Announces New Donation Partner: Global Justice Ecology Project
9. ORNL earns project of year award from tech transfer group
10. China VoIP & Digital Telecom Subsidiary, Beijing PowerUnique Technologies, Wins Virtualization Project Bid for Peking Universitys Third Hospital
11. The NASCAR Foundation Announces The Big Five Projects for NASCAR Day
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... New findings from Fox Chase Cancer Center paint a ... subset of breast cancers that have spread to the ... Tumors that grow into the skin, regardless of size ... classified as stage III and called "locally advanced" ... of cancer, often with poor survival. Locally advanced breast ...
(Date:7/9/2014)... ITHACA, N.Y. Although feelings are personal and ... standard code that objectively represents emotions across different ... study by Cornell University neuroscientist Adam Anderson. , ... within the orbitofrontal cortex, an area of the ... neural code which captures an individual,s subjective feeling," ...
(Date:7/9/2014)... around the world have been linked to an ... from the National Institute for Mathematical and Biological ... also contribute. , In a series of ... severe hemorrhage of internal organs in frogs, could ... if they are exposed to the virus every ...
(Date:7/9/2014)... is one of the most important organs in the ... utilize our food properly this is its synthesis ... our organism this is its detoxification function. Lack ... food all damage the liver. The resulting diseased cells ... and life-threatening liver failure. According to the German Liver ...
(Date:7/9/2014)... , , , , ... , , , , ... KEMAR, the weapon was an SA80 assault rifle and the microphone is 50m downrange from the firer and approximately 30cm from the bullet... , ... , , , , ... , , , , , ...
Breaking Medicine News(10 mins):Health News:Fox Chase researchers recommend updating the staging criteria for breast cancer diagnoses 2Health News:Fox Chase researchers recommend updating the staging criteria for breast cancer diagnoses 3Health News:Study cracks how the brain processes emotions 2Health News:Study predicts ranavirus as potential new culprit in amphibian extinctions 2Health News:Telemedicine for patients with chronic liver diseases 2Health News:Telemedicine for patients with chronic liver diseases 3Health News:Fit for the frontline? New study identifies the hearing requirements of British soldiers 2Health News:Fit for the frontline? New study identifies the hearing requirements of British soldiers 3Health News:Fit for the frontline? New study identifies the hearing requirements of British soldiers 4Health News:Fit for the frontline? New study identifies the hearing requirements of British soldiers 5Health News:Fit for the frontline? New study identifies the hearing requirements of British soldiers 6Health News:Fit for the frontline? New study identifies the hearing requirements of British soldiers 7
... threat to human health by labeling healthy people as sick ... Research Fellow at Bond University in Australia, in a feature ... The feature comes as an international conference ,Preventing Overdiagnosis, is ... by The Dartmouth Institute for Health Policy and Clinical Practice, ...
... one in four people develops hives at some time or another, ... are itchy, red or white bumps, welts or patches on the ... American Academy of Allergy, Asthma & Immunology. Acute hives, which ... are likely a reaction caused by contact with an allergen such ...
... be busier than ever, but Case Western Reserve University ... in fact, it appears to have increased. ... outcome when they analyzed 14 play studies that Russ ... But as they report in "Changes in Children,s ...
... is beneficial to have a loved one present when ... researchers at the Johns Hopkins Bloomberg School of Public ... adults suffering from poor mental health. They examined whether ... hinders physician visit processes and found that older adults ...
... Patricia Dickson, M.D., principal investigator at The Los Angeles ... is co-principal investigator of a project that was just ... for Regenerative Medicine (CIRM). The goal of the ... for the treatment of mucopolysaccharidosis I (MPS I), a ...
... Reporter , TUESDAY, May 29 (HealthDay News) -- Women who ... likely to have a child with autism spectrum disorder or ... or even if, fevers may increase the risk for autism ... not panic if they do develop a fever while pregnant ...
Cached Medicine News:Health News:Overdiagnosis poses significant threat to human health 2Health News:Overdiagnosis poses significant threat to human health 3Health News:Summer's Heat May Enflame Hives 2Health News:Despite less play, children's use of imagination increases over 2 decades 2Health News:Patient mental health overlooked by physician when a family member is present 2Health News:LA BioMed's Dr. Patricia Dickson researching treatments for neurodegenerative disorders 2Health News:Fever During Pregnancy May Raise Odds for Autism in Offspring 2Health News:Fever During Pregnancy May Raise Odds for Autism in Offspring 3
(Date:1/15/2014)... DUBLIN , January 15, 2014 Shire plc ... waived the Office of Fair Trading (OFT) approval condition to the ... Incorporated (NASDAQ: VPHM).   As a result of the ... Shire expects to complete the tender offer on January 24, 2014 ...
(Date:1/15/2014)... 2014 BreedIT Corp (OTC: BRDT), through ... of highly sophisticated agro-breeding solutions for plant breeders and ... Company,s board of directors appointed chemistry and pharmaceutical industry ... member of the board. From 1975 to ...
(Date:1/15/2014)... 2014  In an unprecedented effort to curb the spread of "superbugs" ... transport vehicles, an advanced and portable UV germicidal lamp manufactured by ... time. In order to prevent EMS paramedics and ... West Palm Beach Fire Rescue is the first ...
Breaking Medicine Technology:Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 2Shire Waives OFT Condition Relating to the Acquisition of ViroPharma Inc. 3BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 2BreedIT (OTC: BRDT) Appoints Chemistry and Pharmaceutical Industry Expert Dr. Ben-Zion Weiner to Its Board of Directors 3Superbugs No Longer Ride In Rescue Vehicles 2
... 2011  Ampio Pharmaceuticals, Inc. (Nasdaq: AMPE ) ... develops new uses for previously approved drugs and new ... publications about the Company by anonymous short sellers. The ... stock is a result of factually inaccurate and materially ...
... Thoratec Corporation (Nasdaq: THOR ), a ... save, support and restore failing hearts, today announced the ... directors.  "Bill brings tremendous skill, leadership, and ... to add him to our board of directors," said ...
Cached Medicine Technology:Ampio Responds to Recent Publications by Anonymous Short Sellers 2Thoratec Announces Appointment of William A. Hawkins to Board of Directors 2Thoratec Announces Appointment of William A. Hawkins to Board of Directors 3
... Polypropylene workbench top with ... adjustable from 25"-34". Available in ... Accessories include shelves, drawers, light ... is an expert in custom ...
... steel workbench top with powder-coated ... from 25"-34". Available in hundreds ... include shelves, drawers, light fixtures ... an expert in custom building ...
Perforated or Rod Top, Free Standing or Wall Mounted, Storage Cubby Optional, Polypropylene Construction...
... is configured specifically for pharmaceutical powder ... Panels are precision-joined to create ultra-smooth ... down and disinfect. One-inch radius corners ... creates strong, rigid surface without external ...
Medicine Products: