Navigation Links
Progress toward new chemotherapy agents
Date:3/26/2012

Advances in chemotherapy have dramatically improved the outlook for many cancer patients, but the side effects of this treatment are daunting. A new generation of chemotherapy drugs with fewer side effects is the goal of Edward J. Merino, assistant professor of chemistry at the University of Cincinnati.

Merino will discuss his efforts toward designing these new anticancer agents Tuesday, March 27, at The Chemistry of Life: Spring National Meeting and Exposition of the American Chemical Society in San Diego.

At that meeting, Merino will show a new anticancer agent that targets cancerous cells by zeroing-in on the "pollutants" produced by the characteristic metabolism within tumors. This agent, which Merino calls a "ROS-caged agent," is activated by oxidative stress, a signature of cancerous activity.

"Cancerous cells use energy differently from other cells," Merino said. "Like an automobile engine with the gas pedal pushed to the floor, they give off a unique sort of pollution because they are not as efficient in using energy. Cancer cells don't use metabolism all the way through. We have found key enzymes that contribute to this characteristic signature."

This signature results from the build-up of reactive oxygen species, known as ROS. This environment creates a chemical target that Merino and his team can target with chemical systems. Merino describes his findings as a preliminary description of the factors that can make drug delivery much more selective.

"We are looking for chemicals that operate like heat-seeking missiles that attack only cancerous cells," Merino said. "If we are successful, we can create drugs with far fewer side effects."

The side effects associated with chemotherapy hair loss and weight loss are generated from the mechanism used to target today's family of drugs. Because cancerous cells reproduce rapidly, chemotherapy targets rapidly reproducing cells. The problem, Merino said
'/>"/>

Contact: Greg Hand
greg.hand@uc.edu
513-556-1822
University of Cincinnati
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. American Red Cross Issues One-Month Progress Report for Haiti Earthquake
2. Herpes Drug Might Also Slow HIV Progression
3. Study Reports Progress Against Fatal Brain Cancer
4. Delcath Systems to Conduct Conference Call to Update Investors on Recent Progress
5. HIV and noncommunicable diseases hinder the progress of poor countries Millennium Development Goals
6. Congressional Testimony: Progress Made But Much More to Do for Americas Veterans
7. Fifty years of the light fantastic: Laser advances spark scientific progress
8. Progress In Access To Safe Drinking-Water; Sanitation Needs Greater Efforts
9. Progress Made Against Tough-to-Treat Biliary Tract Cancers
10. Targeting the blood-brain barrier may delay progression of Alzheimers disease
11. Statins may slow progression of multiple sclerosis, new study finds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Progress toward new chemotherapy agents
(Date:6/2/2015)... Branchburg, NJ (PRWEB) June 02, 2015 ... independent verification for non-GMO products made according to ... avoidance. Verified products are produced in compliance with ... testing of all GMO risk ingredients, facility inspections ... possible standards for GMO avoidance. , “Savoury Systems ...
(Date:6/2/2015)... (PRWEB) June 02, 2015 Consumer ... consumer organization, today announced its commitment to help ... to the use of antibiotics sicken about 2.25 ... to the Centers for Disease Control and Prevention. ... President and CEO Marta Tellado participating in the ...
(Date:6/2/2015)... June 02, 2015 Robert LaPrade, ... Officer at the Steadman Philippon Research Institute, participated in ... for Single Sport Specialization? ” This was a collaborative ... (AOSSM) Research Committee that was recently published in the ... this project was limited, there is evidence that early ...
(Date:6/2/2015)... While the movie box office may be ... books themselves are stepping into a new role: that ... produce educational comics in multiple languages that will explain ... - an international effort to address humanity’s most pressing ... energy, inequality, climate change and more. , “The United ...
(Date:6/2/2015)... North Vancouver, B.C., Canada (PRWEB) June 02, 2015 ... American publisher of audit, compliance and risk ... of a new online risk management effectiveness gap-improvement ... reduce the effect of uncertainty on objectives. Organizations ... but they improve their capabilities to do this ...
Breaking Medicine News(10 mins):Health News:Savoury Systems International Receives Non-GMO Project Verification Continuing its Commitment to Provide Customers with Clean Label Ingredients 2Health News:Consumer Reports Aims to Stop the Spread of Superbugs 2Health News:Consumer Reports Aims to Stop the Spread of Superbugs 3Health News:Early Single Sport Specialization May Put Youth Athletes at Risk for Overuse Injuries According to Colorado Knee Specialist Robert LaPrade, MD, PhD 2Health News:Early Single Sport Specialization May Put Youth Athletes at Risk for Overuse Injuries According to Colorado Knee Specialist Robert LaPrade, MD, PhD 3Health News:Can Comics Help the United Nations Save the World? 2Health News:Can Comics Help the United Nations Save the World? 3Health News:Specialty Technical Publishers and Radar Launch Online Assessment Program for Evaluation of Risk Management Effectiveness 2Health News:Specialty Technical Publishers and Radar Launch Online Assessment Program for Evaluation of Risk Management Effectiveness 3Health News:Specialty Technical Publishers and Radar Launch Online Assessment Program for Evaluation of Risk Management Effectiveness 4
... Quarter Revenue of $74.6 Million - , ... Guidance -Fourth Quarter and Full Year 2008 Highlights:- Fourth quarter ... quarter 2007- Full year 2008 total revenue of $250.1 million; ... the second half 2008 of $10 million; exceeds prior guidance ...
... All, Will Solve Crisis and Cut Costs OAKLAND, Calif., ... nurses today praised President Obama,s call for "comprehensive" healthcare ... emphasized that only genuine reform, as in expanding Medicare ... and rein in the skyrocketing costs that the president ...
... Feb. 25 Medarex, Inc. (Nasdaq: MEDX ) ... ended December 31, 2008. Medarex,s net loss for the year ... share, as compared to a net loss of $27.1 million, ... 2008 includes a gain of $151.8 million, or $1.18 per ...
... , , WEDNESDAY, Feb. 25 (HealthDay News) -- U.S. ... drug applications from a Ranbaxy Laboratories plant in India ... Ranbaxy, based in India, is one of the largest ... , "We took this action after it became apparent ...
... of Craneware,s 10th Anniversary YearATLANTA, Feb. 25 Craneware (AIM: CRW.L), ... health systems, is pleased to announce its interim results for the ... , Total of $21.8m ... 28% ...
... Ranbaxy has just received a letter and information ... Paonta Sahib facility have been added to a list ... "AIP". Ranbaxy will analyze the letter and other ... FDA has said it has no evidence the drugs ...
Cached Medicine News:Health News:NuVasive Reports Fourth Quarter and Full Year 2008 Financial Results 2Health News:NuVasive Reports Fourth Quarter and Full Year 2008 Financial Results 3Health News:NuVasive Reports Fourth Quarter and Full Year 2008 Financial Results 4Health News:NuVasive Reports Fourth Quarter and Full Year 2008 Financial Results 5Health News:NuVasive Reports Fourth Quarter and Full Year 2008 Financial Results 6Health News:NuVasive Reports Fourth Quarter and Full Year 2008 Financial Results 7Health News:NuVasive Reports Fourth Quarter and Full Year 2008 Financial Results 8Health News:NuVasive Reports Fourth Quarter and Full Year 2008 Financial Results 9Health News:NuVasive Reports Fourth Quarter and Full Year 2008 Financial Results 10Health News:NuVasive Reports Fourth Quarter and Full Year 2008 Financial Results 11Health News:NuVasive Reports Fourth Quarter and Full Year 2008 Financial Results 12Health News:NuVasive Reports Fourth Quarter and Full Year 2008 Financial Results 13Health News:NuVasive Reports Fourth Quarter and Full Year 2008 Financial Results 14Health News:NuVasive Reports Fourth Quarter and Full Year 2008 Financial Results 15Health News:Nurses Welcome President's Call for Comprehensive Health Reform 2Health News:Medarex Announces 2008 Fourth Quarter and Year End Financial Results 2Health News:Medarex Announces 2008 Fourth Quarter and Year End Financial Results 3Health News:Medarex Announces 2008 Fourth Quarter and Year End Financial Results 4Health News:Medarex Announces 2008 Fourth Quarter and Year End Financial Results 5Health News:Medarex Announces 2008 Fourth Quarter and Year End Financial Results 6Health News:Medarex Announces 2008 Fourth Quarter and Year End Financial Results 7Health News:Medarex Announces 2008 Fourth Quarter and Year End Financial Results 8Health News:Medarex Announces 2008 Fourth Quarter and Year End Financial Results 9Health News:Medarex Announces 2008 Fourth Quarter and Year End Financial Results 10Health News:Medarex Announces 2008 Fourth Quarter and Year End Financial Results 11Health News:Medarex Announces 2008 Fourth Quarter and Year End Financial Results 12Health News:FDA Halts New Applications From Indian Drug Maker's Plant 2Health News:Craneware Announces Half-Year Results 2Health News:Press Statement Issued by Ranbaxy Laboratories Limited 2
(Date:6/2/2015)... today they are expanding their reach nationally by providing customers with on-site 17025 accredited pipette calibrations. ... ... ... ... Photo - http://photos.prnewswire.com/prnh/20150601/219758 ...
(Date:6/2/2015)... 2015  CytRx Corporation (NASDAQ: CYTR ), a ... announced that it has reached an agreement to settle ... Delaware Court of Chancery, which names as ... directors and officers, and names the Company as a ... re CytRx Corp. Stockholder Derivative Litigation , C.A. No. ...
(Date:6/2/2015)... ACTON, Mass. , June 2, 2015  Psychemedics ... global leader for over twenty-five years, announced the addition ... panels. In response to growing abuse concerns, the addition ... panel and D-Amphetamine/Adderall® was added as an option to ... , Chairman and CEO stated:  "Sadly, more and more ...
Breaking Medicine Technology:Integrated Service Solutions, Inc. Announces Nationwide Expansion for On-site Pipette Calibrations 2Integrated Service Solutions, Inc. Announces Nationwide Expansion for On-site Pipette Calibrations 3Integrated Service Solutions, Inc. Announces Nationwide Expansion for On-site Pipette Calibrations 4CytRx Announces Settlement of Stockholder Derivative Lawsuit in Delaware 2CytRx Announces Settlement of Stockholder Derivative Lawsuit in Delaware 3CytRx Announces Settlement of Stockholder Derivative Lawsuit in Delaware 4Psychemedics Announces Addition Of FDA Cleared Drugs 2Psychemedics Announces Addition Of FDA Cleared Drugs 3
... Inc. (Nasdaq: BNVI ) announced today that it ... year 2010 ended September 30, 2010 on Thursday, November 11, ... to review the financial results on Thursday, November 11, 2010 ... the call by dialing (877) 317-6789 or (412) 317-6789, or ...
... 4, 2010 ADVENTRX Pharmaceuticals, Inc. (NYSE Amex: ... Brian M. Culley, will present at the Wall Street Analyst ... 2010 at 12:50 p.m. Eastern time, at The University Club ... a live audio webcast and slide presentation on the Company,s ...
Cached Medicine Technology:
VACUETTE paediatric tubes have decreased sample volumes and are ideal for small childrens' veins and geriatric patients....
... tubes contain a buffered sodium ... with a citrate concentration of ... mol/l (3.8%). The mixing ratio ... to 9 parts blood. In ...
... Cross-match tubes are available ... serum tube contains a clotting ... cross-match tests where serum is ... EDTA cross-match tube is suitable ...
VACUETTE paediatric tubes have decreased sample volumes and are ideal for small childrens' veins and geriatric patients....
Medicine Products: