Navigation Links
Progress toward new chemotherapy agents
Date:3/26/2012

Advances in chemotherapy have dramatically improved the outlook for many cancer patients, but the side effects of this treatment are daunting. A new generation of chemotherapy drugs with fewer side effects is the goal of Edward J. Merino, assistant professor of chemistry at the University of Cincinnati.

Merino will discuss his efforts toward designing these new anticancer agents Tuesday, March 27, at The Chemistry of Life: Spring National Meeting and Exposition of the American Chemical Society in San Diego.

At that meeting, Merino will show a new anticancer agent that targets cancerous cells by zeroing-in on the "pollutants" produced by the characteristic metabolism within tumors. This agent, which Merino calls a "ROS-caged agent," is activated by oxidative stress, a signature of cancerous activity.

"Cancerous cells use energy differently from other cells," Merino said. "Like an automobile engine with the gas pedal pushed to the floor, they give off a unique sort of pollution because they are not as efficient in using energy. Cancer cells don't use metabolism all the way through. We have found key enzymes that contribute to this characteristic signature."

This signature results from the build-up of reactive oxygen species, known as ROS. This environment creates a chemical target that Merino and his team can target with chemical systems. Merino describes his findings as a preliminary description of the factors that can make drug delivery much more selective.

"We are looking for chemicals that operate like heat-seeking missiles that attack only cancerous cells," Merino said. "If we are successful, we can create drugs with far fewer side effects."

The side effects associated with chemotherapy hair loss and weight loss are generated from the mechanism used to target today's family of drugs. Because cancerous cells reproduce rapidly, chemotherapy targets rapidly reproducing cells. The problem, Merino said, is that cells in the stomach lining and cells in our hair follicles also reproduce rapidly so conventional chemotherapy kills those cells, too.

A better understanding of cancer metabolism is an essential part of the work, but so is the basic chemistry involved in creating targeted compounds.

"We are continually making new compounds," Merino said, "but very few of them give any indication of working. Out of hundreds of candidates, we have one moving into a mouse model, and another that looks promising."


'/>"/>

Contact: Greg Hand
greg.hand@uc.edu
513-556-1822
University of Cincinnati
Source:Eurekalert  

Related medicine news :

1. American Red Cross Issues One-Month Progress Report for Haiti Earthquake
2. Herpes Drug Might Also Slow HIV Progression
3. Study Reports Progress Against Fatal Brain Cancer
4. Delcath Systems to Conduct Conference Call to Update Investors on Recent Progress
5. HIV and noncommunicable diseases hinder the progress of poor countries Millennium Development Goals
6. Congressional Testimony: Progress Made But Much More to Do for Americas Veterans
7. Fifty years of the light fantastic: Laser advances spark scientific progress
8. Progress In Access To Safe Drinking-Water; Sanitation Needs Greater Efforts
9. Progress Made Against Tough-to-Treat Biliary Tract Cancers
10. Targeting the blood-brain barrier may delay progression of Alzheimers disease
11. Statins may slow progression of multiple sclerosis, new study finds
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Progress toward new chemotherapy agents
(Date:6/27/2016)... ... June 27, 2016 , ... "FCPX editors can now reveal their media with ... X," said Christina Austin - CEO of Pixel Film Studios. , ProSlice Color ... users can now reveal the media of their split screens with growing colorful ...
(Date:6/26/2016)... ... , ... Quality metrics are proliferating in cancer care, and are derived from ... of the beholder, according to experts who offered insights and commentary in the current ... For the full issue, click here . , For the American Society of ...
(Date:6/26/2016)... ... June 26, 2016 , ... Many women are confused ... endometriosis. These women need a treatment plan to not only alleviate symptoms and ... help for preservation of fertility and ultimately achieving a pregnancy. The specialists at ...
(Date:6/25/2016)... ... June 25, 2016 , ... First Choice Emergency Room , ... Sesan Ogunleye, as the Medical Director of its new Mesquite-Samuell Farm facility. , ... our new Mesquite location,” said Dr. James M. Muzzarelli, Executive Medical Director of First ...
(Date:6/24/2016)... ... June 24, 2016 , ... A recent article ... people are unfamiliar with. The article goes on to state that individuals are now ... of these less common operations such as calf and cheek reduction. The Los Angeles ...
Breaking Medicine News(10 mins):
(Date:6/23/2016)... , June 23, 2016 Any dentist who has ... of the current process. Many of them do not even ... technical difficulties and high laboratory costs involved. And those who ... it at such a high cost that the majority of ... Dr. Parsa Zadeh , founder of Dental Evolutions ...
(Date:6/23/2016)... 2016 Capricor Therapeutics, Inc. ... biotechnology company focused on the discovery, development and ... enrollment in its ongoing randomized HOPE-Duchenne clinical trial ... of its 24-patient target. Capricor expects the trial ... of 2016, and to report top line data ...
(Date:6/23/2016)... , June 23, 2016  Astellas today announced the establishment of Astellas Farma Colombia (AFC), a new affiliate with ... Latin America . ... ... ... ...
Breaking Medicine Technology: