Navigation Links
Programming cells to home to specific tissues may enable more effective cell-based therapies
Date:10/27/2011

Boston, MA - Stem cell therapies hold enormous potential to address some of the most tragic illnesses, diseases, and tissue defects world-wide. However, the inability to target cells to tissues of interest poses a significant barrier to effective cell therapy. To address this hurdle, researchers at Brigham and Women's Hospital (BWH) have developed a platform approach to chemically incorporate homing receptors onto the surface of cells. This simple approach has the potential to improve the efficacy of many types of cell therapies by increasing the concentrations of cells at target locations in the body. These findings are published online in the journal Blood on Oct. 27, 2011.

For this new platform, researchers engineered the surface of cells to include receptors that act as a homing device. "The central hypothesis of our work is that the ability of cells to home to specific tissues can be enhanced, without otherwise altering cell function," said corresponding author Jeffrey M. Karp, PhD, co-director of the Regenerative Therapeutics Center at BWH and a principal faculty member of the Harvard Stem Cell Institute. "By knowing the 'zip code' of the blood vessels in specific tissues, we can program the 'address' onto the surface of the cells to potentially target them with high efficiencies."

While conventional cell therapies that include local administration of cells can be useful, they are typically more invasive with limited potential for multiple doses. "You can imagine, that when the targeted tissue is cardiac muscle, for example to treat heart attacks or heart failure, injecting the cells directly into the heart can be an invasive procedure and typically this approach can only be performed once," said Dr. Karp, also an assistant professor at Harvard Medical School and affiliate faculty Harvard-MIT Division of Health Sciences and Technology.

Using the platform the researchers created, the cells are prepared to travel directly to
'/>"/>

Contact: Holly Brown-Ayers
hbrown-ayers@partners.org
617-534-1603
Brigham and Women's Hospital
Source:Eurekalert  

Page: 1 2

Related medicine news :

1. OASIS Recognized for Brain Fitness Programming
2. Adritech Software Releases Website Realizer, a Website Builder to Create Websites without Any Programming Knowledge
3. University of Michigan Health System earns major grant to expand childhood obesity programming
4. Fetal programming of disease risk to next generation depends on parental gender
5. New Study Uses Adult Stem Cells in Effort to Save Limbs of Patients with Peripheral Arterial Disease
6. New study suggests stem cells sabotage their own DNA to produce new tissues
7. Attacking cancer cells with hydrogel nanoparticles
8. UCR researcher identifies mechanism malaria parasite uses to spread in red blood cells
9. Pittsburgh Neurosurgeons Explore Use of Drug that Illuminates Brain Tumor Cells To Guide Surgery
10. New tool illuminates connections between stem cells and cancer
11. Bitter melon extract attacks breast cancer cells
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Programming cells to home to specific tissues may enable more effective cell-based therapies
(Date:10/31/2014)... Gold Medal Wine Club is making it ... for the wine novice and enthusiasts on their lists with ... , which Early Bird shoppers receive discounts as high as ... , Gift Givers must place their orders before November ... Gold Medal Wine Club adds more value to its Wine ...
(Date:10/31/2014)... York (PRWEB) October 31, 2014 North ... Eye in Garden City, Long Island and the addition ... their medical staff, according to North Shore Eye Care ... the Emeritus Acting Chairman of the Department of Ophthalmology ... successful practice in Garden City for more than 30 ...
(Date:10/31/2014)... RESEARCH UK scientists have found a drug combination that ... - paving the way for new treatments, according to ... Research Institute (NCRI) Cancer Conference in Liverpool next week*. ... initiate a chain of events culminating in self destruction. ... and become immortal. This means that cells grow out ...
(Date:10/31/2014)... October 31, 2014 FindSurrogateMother.com ... remarkable gifts of life — building a family through ... surrogate mothers and donors with hopeful intended parents in ... circumstances. , It’s a collective aptitude of surrogate mothers, ... lawyers, and fertility clinics that help provide these connections ...
(Date:10/31/2014)... (PRWEB) October 31, 2014 Triple Board ... his hair restoration services to transform the appearance of ... the American Academy of Facial Plastic and Reconstruction Surgery ... time to restore the facial hair Jones lost during ... , The pro-bono hair restoration procedure, valued around $16,000, ...
Breaking Medicine News(10 mins):Health News:Gold Medal Wine Club now offering Early Bird Gift Giving Special for Holidays 2Health News:William Kasper, MD Garden City Ophthalmologist, Joins Medical Staff at North Shore Eye Care 2Health News:William Kasper, MD Garden City Ophthalmologist, Joins Medical Staff at North Shore Eye Care 3Health News:Scientists trigger self-destruct switch in lung cancer cells 2Health News:Over 800 New Surrogate Mother Members at FindSurrogateMother.com Helping Create Pathways to Parenthood 2Health News:Over 800 New Surrogate Mother Members at FindSurrogateMother.com Helping Create Pathways to Parenthood 3Health News:Miami Hair Restoration Specialist Transforms Wounded Soldier 2
... ... NanaWall Systems, Inc. announces the NanaWall SL60 is featured in ... competition sponsored by the USGBC for interior designers to showcase the ... experience. The NanaWall connects the hotel suite to an outdoor ...
... ... Downtown Hospital gave a new home to the suddenly displaced, 29th graduating class of ... ... 20, 2010 -- BMCC’s Center for Continuing Education and Workforce Development, in partnership ...
... , ... startup launches Boston based seminar series targeted at IT professionals , ... (PRWEB) May 20, 2010 -- ITSessions ... and World Trade Center on June 17, 2010. This seminar kicks off a new ...
... ... control! Brandi Funk is a nurse practitioner, patient advocate and healthcare writer ... quest to aid consumers. “It is my deep desire to help Americans ... Your Health Care Costs Now!" Funk unveils some of the worst healthcare ...
... Accel Castillo ... ... from Palm Springs Middle School, has taken the top individual honor for the inaugural Fuel ... ,Castillo will be honored at his school on Friday (May 21) and will arrive in ...
... , ... of C.R. Bard Patient Care) and Diane Thome (former Healthcare Market Research Executive) Join The ... Tarrytown, NY ... merger and acquisition (M&A) and strategic growth services for companies in the healthcare industry, is ...
Cached Medicine News:Health News:NanaWall Featured in Award-winning Green Hotel Suite 2Health News:NanaWall Featured in Award-winning Green Hotel Suite 3Health News:St. Vincent's Hospital Closes—and BMCC Rescues its Paramedic Program 2Health News:ITSessions Announces Desktop Virtualization Seminar 2Health News:ITSessions Announces Desktop Virtualization Seminar 3Health News:New Healthcare Book Helps Families Navigate Rising Healthcare Costs and Decreasing Coverage 2Health News:Palm Springs 8th-Grader Wins National 'Fuel Up To Play 60' Award 2Health News:Palm Springs 8th-Grader Wins National 'Fuel Up To Play 60' Award 3Health News:Palm Springs 8th-Grader Wins National 'Fuel Up To Play 60' Award 4Health News:The Walden Group, a Specialized Strategic Healthcare Investment Banking Firm, Adds Key Advisory Services 2Health News:The Walden Group, a Specialized Strategic Healthcare Investment Banking Firm, Adds Key Advisory Services 3
(Date:10/31/2014)... Migranade, Inc. announced today the new migraine ... 36 million U.S. migraine sufferers November, 2014. The medicine ... actual cause of migraines and not just the symptoms. ... source Migranade is assured to be a game changer ... available at http://www.migranade.com and will soon hit ...
(Date:10/31/2014)... , Oct. 31, 2014 Though therapies are ... are expected to show an annual increase of 16.2% ... of nearly $1 billion, according to Kalorama Information,s report, ... proprietary stem cell therapeutics that have gained or are ... "As drug developers tackle ever more complicated conditions, ...
(Date:10/30/2014)... 2014 Stryker Orthopaedics, the Official Joint Replacement ... rounding out its debut year of the relationship at ... AZ. This marks the eleventh tournament stop ... the brand has activated on-site with the "Stryker Mobility ... on the importance of joint health.  ...
Breaking Medicine Technology:Game Changing Migraine Medication To Be Available November 2014 2Report: Stem Cell Technologies Market Growing 2Stryker Mobility Zone Makes Final Stop Of 2014 At Charles Schwab Cup Championship 2Stryker Mobility Zone Makes Final Stop Of 2014 At Charles Schwab Cup Championship 3Stryker Mobility Zone Makes Final Stop Of 2014 At Charles Schwab Cup Championship 4
... Nile Therapeutics, Inc. (Nasdaq: NLTX ), ... for heart failure patients, today announced plans to collaborate ... the clinical development of Nile,s proprietary natriuretic peptide, cenderitide ... "We are very pleased to partner with ...
... /PRNewswire-Asia/ -- ShangPharma Corporation (NYSE: SHP ) ... biotechnology research and development outsourcing company, today announced that ... Care Conference in New York from March 1 – ... Officer of ShangPharma, will host a group presentation at ...
Cached Medicine Technology:Nile Therapeutics to Collaborate with Medtronic on Clinical Development of Cenderitide for Heart Failure and Renal Disease 2Nile Therapeutics to Collaborate with Medtronic on Clinical Development of Cenderitide for Heart Failure and Renal Disease 3ShangPharma to Present at the Citibank Global Health Care Conference from March 1 - 3, 2011 2
Surgical Loupes...
... Made up of doublet objective and ... 2.0x, 2.5x and 3.0x. The true benefit ... Movement whilst maintaining focal clarity is made ... field. The ultra lightweight aluminum bar and ...
Inside and out, the Achieva is designed to unleash a new era, in which the clinical capabilities of MR will further expand....
... The Intradiscal Instruments are designed to ... to aid in disc removal, endplate ... The set consists of several Vertebral ... Retractors, and a Vertebral Body Positioner. ...
Medicine Products: