Navigation Links
Prognostic markers for prostate cancer patients who receive radiation after surgery
Date:11/3/2010

SAN DIEGO, CA (November 3, 2010)Removal of the prostate gland often eradicates early-stage cancer. But patients whose cancer has spread may need to follow up with what is known as salvage radiation therapy. Researchers at Fox Chase have now determined a better way to monitor outcomes after this procedure.

A team led by Mark Buyyounouski, M.D., M.S., radiation oncologist at Fox Chase who will present the results at the annual meeting of the American Society for Radiation Oncology, found that levels of a prostate-specific protein up to 18 months after salvage radiation therapy predict mortality and progression of the disease.

"It's important because if you can identify people who are more likely to die of prostate cancer early, you can talk with them about doing another treatment very quickly, with the hope that it will prolong their lives," says Buyyounouski.

Prostate cancer, the most common cancer in men and the second leading cause of cancer deaths in men, causes nearly 220,000 new cases and more than 30,000 deaths each year. The presence of the disease is indicated by the amount of a protein called prostate-specific antigen (PSA). For men who do not undergo surgery, reaching a PSA level of 2 ng/mL within 18 months after radiation treatment is associated with spread of the disease and higher mortality rates. Buyyounouski and his team were curious about whether the same criterion is important for patients who receive radiation after surgery.

In the study, the scientists looked at 222 patients who went through salvage radiation therapy at Fox Chase between 1991 and 2007. They found that roughly half of the men who surpassed threshold PSA levels in the bloodstream within 18 months after treatment experienced spread of the disease or died within five years. By contrast, men whose PSA levels did not reach the threshold within 18 months did not die within five years, and the likelihood that the disease metastasized was only 17% during that time period. The more quickly the PSA rises, the greater the likelihood the disease will attack other organs and cause death.

"These results provide us with an opportunity to identify patients who should be treated aggressively, before we see any other evidence of prostate cancer," Buyyounouski says. On the other hand, men who approach a PSA level of 2 ng/mL 18 months after treatment or later may not require immediate hormonal therapy, he adds. To confirm the findings, Buyyounouski and his team will next extend the investigation to multiple institutions and a larger set of patients.


'/>"/>

Contact: Diana Quattrone
Diana.Quattrone@fccc.edu
215-728-7784
Fox Chase Cancer Center
Source:Eurekalert

Related medicine news :

1. A prognostic and predictive biomarker for nonsmall cell lung cancer
2. "IPGDx, LLC Announces The Continued Validation Of Its Patented Technology For The Assessment Of Prognosis; PrognostiCheck" Getting the New Information to Patients and Do
3. Radiation pharmacogenomics identifies biomarkers that could personalize cancer treatment
4. Mayo researchers find biomarkers for personalizing radiation cancer treatment
5. Biomarkers May Aid in Early Diagnosis of Alzheimers
6. NIH launches effort to define markers of human immune responses
7. Biomarkers Could Spot Alzheimers Disease Early, Studies Suggest
8. Hydrophobic proteins: Potential biomarkers for colorectal cancer
9. Genetic markers could predict prostate cancer in younger men, U-M study finds
10. UAB researchers find 4 biomarkers important in colorectal cancer treatment prognosis
11. BATTLE links potential biomarkers to drugs for lung cancer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... 2016 , ... As a lifelong Southern Californian, Dr. Omkar Marathe earned his ... David Geffen School of Medicine at UCLA. He trained in Internal Medicine at Scripps ... in hematology/oncology at the UCLA-Olive View-Cedars Sinai program where he had the opportunity to ...
(Date:6/25/2016)... ... June 25, 2016 , ... On Friday, June 10, Van Mitchell, Secretary ... Work award to iHire in recognition of their exemplary accomplishments in worksite health promotion. ... Maryland Workplace Health & Wellness Symposium at the BWI Marriott in Linthicum Heights. iHire ...
(Date:6/24/2016)... CA (PRWEB) , ... June 24, 2016 , ... A ... procedures that most people are unfamiliar with. The article goes on to state that ... but also many of these less common operations such as calf and cheek reduction. ...
(Date:6/24/2016)... ... June 24, 2016 , ... June 19, 2016 is ... associated with chronic pain and the benefits of holistic treatments, Serenity Recovery Center ... suffering with Sickle Cell Disease. , Sickle Cell Disease (SCD) is a disorder of ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Pulmonary Hypertension ... that it will receive two significant new grants to support its work to ... its 25th anniversary by recognizing patients, medical professionals and scientists for their work ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... N.C. , June 24, 2016  Consumers ... decisions and regulators/payers have placed more emphasis on ... environment, patient support programs in the pharmaceutical industry ... patients, medications. Consequently, pharmaceutical companies are focusing on ... they are providing products and services that improve ...
(Date:6/24/2016)... Calif. , June 24, 2016  Global ... a biopharmaceutical company developing novel therapeutics for the ... needs, today announced the closing of its previously ... common stock, at the public offering price of ... the offering were offered by GBT. GBT estimates ...
(Date:6/24/2016)... June 24, 2016 ... announced the addition of the " Global Markets ... This report focuses ... an updated review, including its applications in various applications. ... market, which includes three main industries: pharmaceutical and biotechnology, ...
Breaking Medicine Technology: