Navigation Links
Progesterone is effective for hot flash treatment and provides an alternative to estrogen
Date:6/21/2010

Postmenopausal women who experience bothersome hot flashes or night sweats may have an alternative treatment to estrogen. According to a new study, oral micronized progesterone relieves those symptoms. The results will be presented Saturday at The Endocrine Society's 92nd Annual Meeting in San Diego.

"This is the first evidence that oral micronized progesterone, which is molecularly identical to the natural hormone, is effective for women with symptomatic hot flashes," said the presenting author, Jerilynn Prior, MD, professor, University of British Columbia, Vancouver, Canada.

Available only by prescription and sold under the brand name Prometrium in the United States and Canada, this form of progesterone is manufactured from a steroid in yams.

"Vasomotor symptoms"hot flashes (sometimes called hot flushes) and night sweatsare experienced by most women during the years around the final menstrual period. In the most symptomatic women (at least 5-10%) these symptoms disturb sleep, energy and quality of life, Prior said.

The researchers recruited 114 healthy postmenopausal women seeking hormonal therapy for hot flashes and night sweats and randomly assigned them to take either oral micronized progesterone or an inactive substance (placebo), both as three round capsules at bedtime. Neither the women nor the study team members were aware which treatment the study participants received during the three months of therapy. The time since their last menstrual flow was one to 10 years, with an average of four years. To be eligible to participate in the study, women could not have taken ovarian hormone therapy within the past six months.

Prior and Christine Hitchcock, PhD, of the University of British Columbia, calculated the average daily vasomotor symptom score, or VMSScore, from the data that subjects recorded in a daily diary. This score reflects both intensity and number for hot flashes and night sweats each day.

Progesterone, in a 300-milligram dose, was more effective than placebo at decreasing the intensity and number of symptoms, the authors reported, and the difference was both statistically significant and clinically important. The 68 women taking progesterone showed a 56% improvement from baseline in VMSScore, and a 48% reduction in the number of VMS; the 46 women taking placebo had 28% lower VMSScores and a 22% reduction in number.

"Women improve very quickly on oral micronized progesterone. The improvement is apparent within the first 4 weeks," Prior said.

Micronized progesterone did not cause any serious side effects, she said. The drug may be an option for postmenopausal women who do not want to or should not take estrogen"currently the only effective therapy for decreasing severe vasomotor symptoms," Prior said.


'/>"/>

Contact: Aaron Lohr
alohr@endo-society.org
240-482-1380
The Endocrine Society
Source:Eurekalert

Related medicine news :

1. Watson Announces Agreement to Acquire U.S. Rights to Columbia Laboratories CRINONE(R) Progesterone Gel Product Line
2. Cutting carbs is more effective than low-fat diet for insulin-resistant women
3. Prize-winning budgeting model aims for more effective marketing spending
4. Study Demonstrates a Safe and Cost Effective Source of Recombinant Human Transferrin
5. Brilliance Weight Loss Will Give You the Tools for Effective Weight Loss
6. Questioning the effectiveness of oil dispersants in Gulf oil spill
7. New combination effective against pancreatic cancer
8. Carotid artery ultrasound is an effective alternative to more invasive coronary angiography
9. Study finds beta blockers alone more effective for first variceal bleeding
10. Non-IV-administered medication just as effective in stopping seizures
11. Smoke-free air laws effective at protecting children from secondhand smoke
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/21/2017)... , ... September 21, 2017 , ... 38-Year-Old Plastic Surgeon ... Center in Naples, Florida is pleased to announce that Plastic Surgeon Kiranjeet Gill has ... 40 Under 40 is an annual award that was started in 2003 to ...
(Date:9/21/2017)... CA (PRWEB) , ... September 21, 2017 , ... ... lunch and learn with Infinity Behavioral Health Services for professionals in the addiction ... a Commercial Payer Audit . , Insurance companies and state and federal ...
(Date:9/21/2017)... ... September 21, 2017 , ... Demonstrating a consistent ... health departments have been awarded five-year accreditation status through the Public Health ... being served by a PHAB-accredited health department now extend to more than ...
(Date:9/21/2017)... (PRWEB) , ... September 21, 2017 , ... ... using Microscan’s LVS 7510 at the Global GS1 Healthcare Conference 2017 in Chicago, ... the life-sciences industry for ensuring label quality and improving patient safety. , ...
(Date:9/21/2017)... ... September 21, 2017 , ... Japanese Zen artist couple, Fumie and Kentaro ... 7th and 8th October at Miranda Kuo Gallery on Lower East Side, NYC. This ... Zen Kodo mat. Wanderlust , one of the largest US yoga online media ...
Breaking Medicine News(10 mins):
(Date:9/7/2017)... Caris Life Sciences, a leading innovator ... of precision medicine, today announced results from two ... molecular profiling approach in guiding therapeutic strategies in ... (CGP+) with Caris Molecular Intelligence ® to ... level, leading to more therapeutic options and improved ...
(Date:9/7/2017)... --  BioLife Solutions , Inc. (NASDAQ: BLFS ), ... cell and tissue hypothermic storage and cryopreservation ... President and CEO, will be presenting at two investment conferences ... 19 th Annual Global Investment Conference on Tuesday, September ... The conference is being held at the New York Palace ...
(Date:9/6/2017)... --  PDI , a leader in infection prevention products ... session focused on the role of chlorhexidine gluconate (CHG) ... 2017 Annual Scientific Meeting of the Association for Vascular ... Phoenix Convention Center in ... also feature PDI,s Prevantics® Device Swab as ...
Breaking Medicine Technology: