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Progen Technology Switches on Cancer Fighting Genes and Inhibits Tumor Growth
Date:4/20/2009

BRISBANE, Australia, April 20 /PRNewswire-FirstCall/ --Progen Pharmaceuticals Limited (ASX: PGL; Nasdaq: PGLA) has released data that shows its epigenetic technology successfully inhibits tumor growth.

The results of the pre-clinical experiments, presented by Progen's collaborators at the 100th Annual American Association for Cancer Research (AACR) Conference, revealed Progen's product was effective in 'switching on' important anti-cancer genes - a significant achievement in epigenetics research and cancer therapeutics.

Progen CEO Justus Homburg said the latest findings reinforced Progen's position at the forefront of anti-cancer drug research.

"Epigenetics represents an exciting new target for cancer therapeutics and is a focus of this AACR meeting. We are very proud to have achieved such promising results in this exciting area of research," he said.

Epigenetics technology represents one of the latest breakthroughs in cancer drug development which focuses on expression (switching on) or silencing (switching off) of certain genes.

Progen and its collaborators have focused their research on an enzyme known as lysine specific demethylase 1(LSD1), which contributes to the silencing of important tumor suppressor genes. They have successfully developed PG11144 that inhibits LSD1 and reactivates (expresses) the silenced genes that are inactivated in cancer.

Progen's Chief Scientific Officer Dr Laurence Marton said the results showed the product successfully inhibited tumor growth in test tubes and living organisms.

"We believe the use of LSD1 inhibitors represents a highly promising and novel approach to cancer prevention and therapy, and may be suitable for multiple indications."

In addition to its epigenetics findings, Progen also pre
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SOURCE Progen Pharmaceuticals Limited
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