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Professor receives grant to develop more rapid technology for screening blood samples
Date:11/4/2009

between the chip and the captured substances. Then an electrospray, which is similar to a solvent aerosol spray, shoots through the mesh chip and transfers the different compounds into the mass spectrometer for analysis.

By analyzing the mass spectrometric data, says Brodbelt, scientists should be able to measure the presence and quantity of different compounds, and to do so on a scale, and with a speed, that wasn't possible before.

"The payoff could be big," she says. "It's a different strategy than what might be pursued by molecular biologists or biochemists. They'll often focus on studying one or two proteins at a time, and develop a really deep understanding of those proteins. We're looking for the more generalized profile, and we may notice some patterns that weren't apparent to them.

"There are so many other areas where you'd want to do profiling. It might involve looking for pesticides as part of an environmental study, or doing protein-related work or drug profiling work. If this approach is successful, I imagine other groups will try to develop these chips as well."

Brodbelt's grant, which is being funded as part of the American Recovery and Reinvestment Act (ARRA) government stimulus package, is a "Challenge Grant," meant to encourage high-risk, high-reward research projects that may produce results quickly.

This is the second NIH grant in two years that Brodbelt and the Guziecs have received. In 2008, the collaborating groups received a four-year, $1,113,615 grant to evaluate an innovative technique that could assess the anti-cancer activity of new compounds.


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Contact: Jennifer Brodbelt
jbrodbelt@mail.utexas.edu
512-471-0028
University of Texas at Austin
Source:Eurekalert

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