Navigation Links
Professor Develops Blood Test for Alzheimer’s Disease Risk
Date:7/29/2014

Pomona, California (PRWEB) July 29, 2014

A team of scientists, led by Western University of Health Sciences Professor Doug Ethell, PhD, has developed a blood test for Alzheimer’s disease risk that may lead to earlier detection and the development of Alzheimer’s disease interventions, according to an article published July 29, 2014.

“Alzheimer’s disease is a puzzle, and this study represents one of several pieces that have locked into place for us over the past couple of years,” Ethell said.

The study, “Women with the Alzheimer's risk marker ApoE4 lose Aß-specific CD4+ T cells 10-20 years before men,” describes how the new test gauges the immune responses to a component of brain plaques associated with the disease. Carriers of the Alzheimer’s risk factor ApoE4 showed an earlier decline in this response than non-carriers, by about a decade.

Women showed an earlier decline than men, which is consistent with a 2.5-fold higher risk of Alzheimer’s disease. Women who carried ApoE4 showed the earliest decline of any group, with a precipitous drop found between the ages of 45 and 52, when menopause typically begins.

Aß-specific CD4+ T cells have a central role in regulating adaptive immune responses to antigens, and have been shown to reduce AD pathology in mouse models. As these cells may facilitate endogenous mechanisms that counter AD, an evaluation of their abundance before and during AD provides important insights, according to the study.

“It’s very exciting because it changes the way we think about this disease, and opens the door to some interesting possibilities,” Ethell said.

The assay may provide an early indicator of changes that precede Alzheimer’s disease by a decade or more by quantifying Aß-specific CD4+ T cells in human blood. This assay, called CD4see, could accelerate clinical testing of new Alzheimer’s disease interventions that require an early biomarker.

“Our team is very close to figuring out the cause of Alzheimer’s disease,” Ethell said. “We are working on the next piece and if that falls into place, we could be treating early- and middle-stage Alzheimer’s disease patients within three to five years.”

The article was published in Translational Psychiatry, from Nature Publishing Group. Click here to view the article: http://www.nature.com/tp/journal/v4/n7/full/tp201451a.html.

Read the full story at http://www.prweb.com/releases/2014/07/prweb12055740.htm.


'/>"/>
Source: PRWeb
Copyright©2014 Vocus, Inc.
All rights reserved

Related medicine news :

1. Louisiana Tech University professor earns NSF Early Career Development grant
2. Clemson professor awarded nearly $600,000 4-year grant to study language of plants
3. Louisiana Tech biomedical engineering professor earns recognition, funding for research
4. Women professorships low in some Scandinavian universities due to sexism
5. President Obama names SF State math professor a top young scientist
6. From textbook to flexbook: Professor uses new collaborative tool in the classroom
7. IHME professor named first health measurement winner of prestigious innovation award
8. Guys, take note: Male birth control pill may be ready soon, says Texas A&M professor
9. UBC professor wins Canadas top pharmaceutical research award
10. Huddersfield professors ground-breaking research shows just how well the 2012 Games were run
11. Grove Professor receives $1.5MM to study breast cancer therapies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/26/2016)... Charlotte, NC (PRWEB) , ... June 26, 2016 , ... Brent Kasmer, a legally blind ... able to be personalized through a fitness app. The fitness app plans to fix the ... solutions currently only offer a one size fits all type program , They ...
(Date:6/25/2016)... FL (PRWEB) , ... June 25, 2016 , ... The temporary closing of Bruton Memorial ... Plant City Observer , brings up a new, often overlooked aspect of head lice: the ... closing for fumigation is not a common occurrence, but a necessary one in the event ...
(Date:6/25/2016)... ... June 25, 2016 , ... Dr. Calvin Johnson has dedicated ... has implemented orthobiologic procedures as a method for treating his patients. The procedure ... doctors to perform the treatment. Orthobiologics are substances that orthopaedic surgeons use to ...
(Date:6/24/2016)... ... June 24, 2016 , ... Those who have experienced traumatic events may ... to unhealthy avenues, such as drug or alcohol abuse, as a coping mechanism. To ... for healthy coping following a traumatic event. , Trauma sufferers tend to feel a ...
(Date:6/24/2016)... ... , ... Global law firm Greenberg Traurig, P.A. announced that 20 Florida attorneys ... peers for this recognition are considered among the top 2 percent of lawyers practicing ... members of this year’s Legal Elite Hall of Fame: Miami Shareholders Mark D. ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... , June 24, 2016  Collagen Matrix, ... design, development and manufacturing of collagen and mineral ... announced today that Bill Messer has ... Marketing to further leverage the growing portfolio of ... devices. Bill joins the Collagen Matrix ...
(Date:6/24/2016)... 2016 The Academy of Managed Care Pharmacy ... that would allow biopharmaceutical companies to more easily share ... formulary and coverage decisions, a move that addresses the ... The recommendations address restrictions in the sharing ... drug label, a prohibition that hinders decision makers from ...
(Date:6/24/2016)... June 24, 2016   Pulmatrix, Inc ., (NASDAQ: ... innovative inhaled drugs, announced today that it was added ... reconstituted its comprehensive set of U.S. and global ... is an important milestone for Pulmatrix," said Chief Executive ... awareness of our progress in developing drugs for crucial ...
Breaking Medicine Technology: