Navigation Links
Professor Develops Blood Test for Alzheimer’s Disease Risk
Date:7/29/2014

Pomona, California (PRWEB) July 29, 2014

A team of scientists, led by Western University of Health Sciences Professor Doug Ethell, PhD, has developed a blood test for Alzheimer’s disease risk that may lead to earlier detection and the development of Alzheimer’s disease interventions, according to an article published July 29, 2014.

“Alzheimer’s disease is a puzzle, and this study represents one of several pieces that have locked into place for us over the past couple of years,” Ethell said.

The study, “Women with the Alzheimer's risk marker ApoE4 lose Aß-specific CD4+ T cells 10-20 years before men,” describes how the new test gauges the immune responses to a component of brain plaques associated with the disease. Carriers of the Alzheimer’s risk factor ApoE4 showed an earlier decline in this response than non-carriers, by about a decade.

Women showed an earlier decline than men, which is consistent with a 2.5-fold higher risk of Alzheimer’s disease. Women who carried ApoE4 showed the earliest decline of any group, with a precipitous drop found between the ages of 45 and 52, when menopause typically begins.

Aß-specific CD4+ T cells have a central role in regulating adaptive immune responses to antigens, and have been shown to reduce AD pathology in mouse models. As these cells may facilitate endogenous mechanisms that counter AD, an evaluation of their abundance before and during AD provides important insights, according to the study.

“It’s very exciting because it changes the way we think about this disease, and opens the door to some interesting possibilities,” Ethell said.

The assay may provide an early indicator of changes that precede Alzheimer’s disease by a decade or more by quantifying Aß-specific CD4+ T cells in human blood. This assay, called CD4see, could accelerate clinical testing of new Alzheimer’s disease interventions that require an early biomarker.

“Our team is very close to figuring out the cause of Alzheimer’s disease,” Ethell said. “We are working on the next piece and if that falls into place, we could be treating early- and middle-stage Alzheimer’s disease patients within three to five years.”

The article was published in Translational Psychiatry, from Nature Publishing Group. Click here to view the article: http://www.nature.com/tp/journal/v4/n7/full/tp201451a.html.

Read the full story at http://www.prweb.com/releases/2014/07/prweb12055740.htm.


'/>"/>
Source: PRWeb
Copyright©2014 Vocus, Inc.
All rights reserved

Related medicine news :

1. Louisiana Tech University professor earns NSF Early Career Development grant
2. Clemson professor awarded nearly $600,000 4-year grant to study language of plants
3. Louisiana Tech biomedical engineering professor earns recognition, funding for research
4. Women professorships low in some Scandinavian universities due to sexism
5. President Obama names SF State math professor a top young scientist
6. From textbook to flexbook: Professor uses new collaborative tool in the classroom
7. IHME professor named first health measurement winner of prestigious innovation award
8. Guys, take note: Male birth control pill may be ready soon, says Texas A&M professor
9. UBC professor wins Canadas top pharmaceutical research award
10. Huddersfield professors ground-breaking research shows just how well the 2012 Games were run
11. Grove Professor receives $1.5MM to study breast cancer therapies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/25/2016)... ... May 25, 2016 , ... The World Molecular Imaging Society ... Imaging.” The focus of ADDMI-IG will be geared towards how using molecular imaging ... Through ADDMI-IG WMIS will provide a platform for productive discussions about the implementation ...
(Date:5/25/2016)... ... May 25, 2016 , ... TransactRx announces the ... adjudication of medical service claims by Pharmacy Benefit Managers that were submitted by ... software. The TransactRx Cross Benefit Clearinghouse receives standard professional medical claims submitted from ...
(Date:5/25/2016)... ... 2016 , ... For more than fifty years, we've suffered whiplash as each new scientific study ... to the latest nutritional advice – advice that was supposed to keep us healthy and ... 3 American adults are considered to be overweight and more than 1 in 3 adults ...
(Date:5/25/2016)... ... , ... Consumer access to organic foods and grower access to food processers ... grain cereals and other plant-based foods, will introduce the first consumer product (a new ... by Hesco/Dakota Organic Products. , The transitional designation means the cereal was made using ...
(Date:5/24/2016)... ... , ... According to an article published May 11th on Fox ... the amount of calories they consumed by 25% experienced some interesting health benefits. This ... improved quality of life, and enhanced sexual function compared to the other group, which ...
Breaking Medicine News(10 mins):
(Date:5/23/2016)... 2016 Transparency Market Research has ... Insufficiency Market - Global Industry Analysis, Size, Share, Growth, ... the report, the exocrine pancreatic insufficiency market is anticipated ... to 2023 to reach US$2.85 Bn by 2023. ... by the deficiency of the exocrine pancreatic enzymes, causing ...
(Date:5/23/2016)... , May 23, 2016 ... Devices, Diagnostics and Monitoring, and Vision Care ... Which areas are going to grow at the fastest ... revenues to 2026, assessing data, trends, opportunities and prospects. ... charts, and graphs. Discover the most lucrative areas in ...
(Date:5/23/2016)... 2016 Non-invasive diagnostic test realizes ... diseases; ,Technology to be presented at Yissum’s booth, at ... Development Company of the Hebrew University of Jerusalem ... with Aurum Ventures MKI, the technology investment arm of ... diagnostic approach for early detection of multiple diseases by ...
Breaking Medicine Technology: