Navigation Links
Proepithelin encourages cell growth and migration in prostate cancer
Date:2/26/2009

(PHILADELPHIA) Researchers from Thomas Jefferson University have identified a protein that appears to play a significant role in the growth and migration of prostate cancer cells, especially androgen-independent prostate cancer cells. The study was published in the American Journal of Pathology.

They also found that prostate cancer cells express more of the protein when compared to normal prostate cells, according to Andrea Morrione, Ph.D., an associate professor and director of Urology Research for the Kimmel Cancer Center at Jefferson.

Dr. Morrione conducted the study with Leonard Gomella, M.D., chairman of the department of Urology, Raffaele Baffa, M.D., an associate professor in the department of Urology, and Renato V. Iozzo, M.D., Ph.D., professor in the department of Pathology, Anatomy and Cell Biology.

Proepithelin is a growth factor that promotes cell cycle progression and cell growth in many cellular systems. According to Dr. Morrione, the overexpression of proepithelin by prostate cancer cells may prove to be a useful clinical marker to diagnose prostate cancer.

The presence of proepithelin also encourages cell migration, which is necessary for tumor metastasis. Thus, it may serve as a marker for metastasis.

Proepithelin has previously been shown to play a role in the formation of bladder cancer, and its overexpression is related to an aggressive form of breast cancer according to Dr. Morrione. It also has been shown to play a role in many other cancers, including glioblastomas, multiple myeloma, renal cell carcinoma, gastric cancer and ovarian cancer.

"There are two possible implications of our findings," Dr. Morrione said. "First, proepithelin could be a therapeutic target since it is overexpressed in prostate cancers.

Second, the overexpression of proepithelin could serve as a biomarker and be a diagnostic tool for prostate cancer."

Although localized prostate cancers are potentially curable by surgery and/or radiation therapy, there is no uniform effective treatment for hormone-refractory prostate cancer. There are no reliable prognostic markers to identify which of patients are likely to progress to metastatic disease.

Results of this study will also be presented at the 2009 ASCO Genitourinary Cancers Symposium.


'/>"/>

Contact: Emily Shafer
emily.shafer@jefferson.edu
215-955-5291
Thomas Jefferson University
Source:Eurekalert

Related medicine news :

1. GIVE IT A REST: Delta Dental of Illinois Encourages Routine Dental Exams to Help Detect Nighttime Teeth Grinding
2. Grammy-nominated Singer Angie Stone Encourages African-Americans in Birmingham to Fearlessly FACE Diabetes
3. "12 Days of UNICEF" Encourages Americans to Give Gifts that Give Back This Holiday Season
4. The American Lung Association of the Central States Encourages Kansas City Residents to See Themselves Among the Many Faces of Influenza
5. The American Lung Association of Ohio Encourages Cleveland Residents to See Themselves Among The Many Faces of Influenza
6. NCPA Encourages Member Pharmacists to Consider Refraining From Selling Tobacco Products
7. Combined Insurance Encourages Consumers to Assess Insurance Plans and Protection During Lung Cancer Awareness Month
8. McDonalds(R) Encourages Kids to Take One Minute to Move It
9. Philips Norelco Encourages Americans to Change the Face of Mens Health: Grow a Moustache This November and Raise Awareness for Prostate Cancer Research
10. Suze Orman Joins got milk? Milk Mustache Campaign: New Ad Encourages Families To Invest in Milks Nutritional Assets
11. Combined Insurance Encourages Women to Assess Insurance Plans and Protection During Breast Cancer Awareness Month
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/25/2016)... ... , ... Conventional wisdom preaches the benefits of moderation, whether it’s a matter ... bar too high can result in disappointment, perhaps even self-loathing. However, those who set ... , Research from PsychTests.com reveals that behind the tendency to set low ...
(Date:6/24/2016)... ... June 24, 2016 , ... Marcy was in a crisis. Her son James, eight, was out ... family verbally and physically. , “When something upset him, he couldn’t control his emotions,” remembers ... would throw rocks at my other children and say he was going to kill them. ...
(Date:6/24/2016)... ... June 24, 2016 , ... Comfort Keepers® of San Diego, CA is excited ... To Recovery® program to drive cancer patients to and from their cancer treatments. ... highest quality of life and ongoing independence. Getting to and from medical treatments ...
(Date:6/24/2016)... ... June 24, 2016 , ... The Haute ... Dr. Barry M. Weintraub as a prominent plastic surgeon and the network’s newest ... world, and the most handsome men, look naturally attractive. Plastic surgery should be ...
(Date:6/24/2016)... Washington, D.C. (PRWEB) , ... June 24, 2016 , ... ... Pro-Am Heroes Golf Classic Tournament held on June 20th at the Woodmont Country ... local charity, Luke’s Wings, an organization dedicated to helping service members that have been ...
Breaking Medicine News(10 mins):
(Date:6/24/2016)... N.C. , June 24, 2016  Consumers ... decisions and regulators/payers have placed more emphasis on ... environment, patient support programs in the pharmaceutical industry ... patients, medications. Consequently, pharmaceutical companies are focusing on ... they are providing products and services that improve ...
(Date:6/24/2016)... DUBLIN , June 24, 2016 ... and Markets has announced the addition of the ... their offering. ... products and provides an updated review, including its applications ... covering the total market, which includes three main industries: ...
(Date:6/24/2016)... Mass. and SAN CLEMENTE, Calif. , ... California -based mobile pulmonary function testing company, is now able ... PFT devices developed by ndd Medical Technologies , Inc. ... testing done in hospital-based labs.  Thanks to ndd,s EasyOne PRO ® ... , can get any needed testing done in the comfort ...
Breaking Medicine Technology: