Navigation Links
Process found to play role in rheumatoid arthritis could lead to new treatment
Date:1/29/2009

Although the origin of rheumatoid arthritis (RA) remains unclear, bioactive proteins known as cytokines, particularly TNFα and IL-6, which are involved in inflammation, play a major role in the disease by contributing to joint and tissue destruction. Placenta growth factor (PIGF), another cytokine, has been thought to be critical for a new blood vessel formation in the placenta to sufficiently deliver oxygen and nutrients to fetus. A new study examined the effects of PIGF on the inflammatory process of RA. The results suggest that PIGF may play an important role in inflammation in RA joints. The study was published in the February issue of Arthritis & Rheumatism (http://www3.interscience.wiley.com/journal/76509746/home).

Led by Wan-Uk Kim of Catholic University of Korea inSeoul, Korea, researchers analyzed blood and synovial fluid cells from RA patients and healthy controls and found that synovial cells were the major source of PIGF production in RA patients and that PIGF stimulates TNFα and IL-6 production. They also found that the PlGF-induced increases in TNFα and IL-6 production may be caused by high levels of flt-1, a PlGF receptor, which are linked to the inflammatory response of RA patients. In addition, the researchers identified a novel peptide to inhibit PlGF action. When injected into arthritic mice, this peptide reduced the severity of arthritis and prevented its progression. They also found that elimination of PIGF gene in mice prevented the development of antibody-induced arthritis.

The peptide they identified inhibits binding of PIGF to its receptor flt-1and could be valuable from a clinical standpoint, since it is easily synthesized and does not elicit unwanted immune response.

"These findings provide new insight into the pathogenic mechanism of RA and emphasize the importance of PIGF and flt-1 as potential candidates for th
'/>"/>

Contact: Sean Wagner
medicalnews@bos.blackwellpublishing.com
781-388-8550
Wiley-Blackwell
Source:Eurekalert

Page: 1 2

Related medicine news :

1. Brain imaging reveals breakdown of normal emotional processing
2. NYU study points to lasting impact of mild hearing loss on neurological processes
3. Pharmaceutical Manufacturing Quality: Optimizing Your Internal Process for FDA Compliance
4. MedImmune Resolves FDA Observations Regarding Manufacturing Process for FluMist(R)
5. Delhaize Group Selects Trintechs AssureNET GL to Improve Compliance Process Efficiency
6. Labopharm provides update on U.S. regulatory process for once-daily Tramadol
7. BioProcessors Launches SimCell(TM) Services to Meet Increased Customer Demand
8. Orthofix International Acquires InSWing(TM) Interspinous Process Spacer
9. Cruel Deaths in Mexico a Result of Closing U.S. Horse Processing Plants: AVMA
10. Green Pet Products Introduces a New, Innovative Process to the Small Animal and Bird Litter/Bedding Category
11. ThermoGenesis Announces 510(k) Clearance for AutoXpress(TM) Cord Blood Processing System
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/23/2014)... the first year follow a set of predictable ... and first words. However, previous research had not ... between hearing and deaf infants. Now, University of ... motivated by infants, ability to hear their own ... received cochlear implants to help correct their hearing ...
(Date:9/23/2014)... found that FDG-PET technology is less accurate in ... where infections like histoplasmosis or tuberculosis are common. ... could lead to unnecessary tests and surgeries for ... , Histoplasmosis and other fungal diseases are linked ... droppings and are found in soils. , The ...
(Date:9/23/2014)... September 23, 2014 World of Home ... philanthropic support. Most recently, the gym has been raising ... Fitness program. Throughout the year, World of Home Fitness ... charitable causes. , Over the summer, World of Home ... Through their Ageless Fitness program, participants helped feed seniors ...
(Date:9/23/2014)... 23, 2014 As a consumer in ... a purchase. It’s difficult to trust testimonials that are ... them to manipulate their customers into saying anything. , ... they tend to lack in depth coverage on a ... was founded to fix this issue and focus on ...
(Date:9/23/2014)... Karen Pallarito HealthDay Reporter ... if doctors and hospitals got paid for providing better ... better data for making informed health choices. A ... is headed. The report, from the IMS Institute for ... -- recent events expected to alter the delivery of health ...
Breaking Medicine News(10 mins):Health News:Infant cooing, babbling linked to hearing ability, MU researcher finds 2Health News:Study questions accuracy of lung cancer screens in some geographic regions 2Health News:World of Home Fitness Supports Meals on Wheels 2Health News:Consumer Health Reports Debuts Revolutionary Review Website 2Health News:Report Identifies Game Changers for U.S. Health Care 2Health News:Report Identifies Game Changers for U.S. Health Care 3
... CHICAGO For years, it was believed that obese women ... body fat actually protected against bone loss. However, a study ... of North America (RSNA) found that having too much internal ... bone health. "We know that obesity is a major ...
... , CAMBRIDGE, Mass. (November 29, 2010) Whitehead Institute ... the microRNA 125b (miR-125b) can independently cause leukemia and ... this week,s online edition of the Proceedings of the ... in many cancers, but in humans and mice, can ...
... With the emergence of an epidemic of obesity and type ... habits that may affect the risk of metabolic diseases is ... drinkers tend to have about 30% lower risk of developing ... tend to be at lower risk of developing metabolic ...
... Goodwin HealthDay Reporter , MONDAY, Nov. 29 (HealthDay ... teens over the last few decades, with some of the ... a new report. In one startling statistic cited in ... and Quality found that hospitalizations for eating disorders jumped by ...
... iridescence of a butterfly,s wing, investigators at the University ... and Applied Sciences have developed a color-changing patch that ... indicate the strength of exposure to blasts from explosives ... color change to the intensity of exposure to provide ...
... , MONDAY, Nov. 29 (HealthDay News) -- Children and teens ... triclosan may be at increased risk for hay fever and ... can actually make people sick, researchers say. The study ... bisphenol A (BPA) may weaken an adult,s immune system. ...
Cached Medicine News:Health News:Belly fat puts women at risk for osteoporosis 2Health News:Tiny RNA shown to cause multiple types of leukemia 2Health News:Tiny RNA shown to cause multiple types of leukemia 3Health News:Moderate alcohol consumption lowers the risk of metabolic diseases 2Health News:Rate of Eating Disorders in Kids Keeps Rising 2Health News:Rate of Eating Disorders in Kids Keeps Rising 3Health News:Color-changing 'blast badge' detects exposure to explosive shock waves 2Health News:Too Much Hygiene May Affect Immune System, Study Suggests 2
(Date:9/23/2014)... HACKENSACK, N.J. , Sept. 23, 2014   ... million in a planned $7 million Series A funding ... participation from Med-Metrix. COTA is the first big data ... outcomes data and cost analysis for cancer care in ... funds will be used to expand development of the ...
(Date:9/23/2014)... Sept. 23, 2014  Medela announced today that it ... (ABC), assigning Medela as the exclusive distributor of the ... the Medela Enteral Feeding Pump. Through this agreement, Medela ... parents and healthcare professionals by offering a comprehensive set ... Feeding Pump is integral to the delivery of human ...
(Date:9/23/2014)... 2014 CASI Pharmaceuticals, Inc. (Nasdaq: ... development and commercialization of innovative therapeutics addressing cancer and ... a primary focus on China , ... MD, Chairman and Chief Executive Officer of Spectrum Pharmaceuticals, ... made in connection with the recently announced acquisition of ...
Breaking Medicine Technology:COTA Closes $3.7M of Planned $7M Series A Funding Round to Transform Cancer Outcomes and Reimbursement 2COTA Closes $3.7M of Planned $7M Series A Funding Round to Transform Cancer Outcomes and Reimbursement 3COTA Closes $3.7M of Planned $7M Series A Funding Round to Transform Cancer Outcomes and Reimbursement 4Medela Enters Exclusive Enteral Feeding Pump Agreement with Atlanta Biomedical Company 2CASI Pharmaceuticals Announces Appointment Of Rajesh C. Shrotriya, MD To The Board Of Directors 2CASI Pharmaceuticals Announces Appointment Of Rajesh C. Shrotriya, MD To The Board Of Directors 3CASI Pharmaceuticals Announces Appointment Of Rajesh C. Shrotriya, MD To The Board Of Directors 4
... , , NEW YORK, Dec. 15 ... report is available in its catalogue: , ... U.S. and its International Trade [Q4 2009 Edition] ... released December edition of Surgical and Medical Instrument ...
... , , NEW YORK, ... market research report is available in its catalogue: ... of the competitive environment is unquestionably one of ... to business survival, growth and profitability. Timely and ...
Cached Medicine Technology:Reportlinker Adds Surgical and Medical Instrument Manufacturing Industry in the U.S. and its International Trade [Q4 2009 Edition] 2Reportlinker Adds Surgical and Medical Instrument Manufacturing Industry in the U.S. and its International Trade [Q4 2009 Edition] 3Reportlinker Adds Surgical and Medical Instrument Manufacturing Industry in the U.S. and its International Trade [Q4 2009 Edition] 4Reportlinker Adds Surgical and Medical Instrument Manufacturing Industry in the U.S. and its International Trade [Q4 2009 Edition] 5Reportlinker Adds Surgical and Medical Instrument Manufacturing Industry in the U.S. and its International Trade [Q4 2009 Edition] 6Reportlinker Adds Surgical and Medical Instrument Manufacturing Industry in the U.S. and its International Trade [Q4 2009 Edition] 7Reportlinker Adds Surgical and Medical Instrument Manufacturing Industry in the U.S. and its International Trade [Q4 2009 Edition] 8Reportlinker Adds Top Ten World's Leading Orthopedics Companies 2Reportlinker Adds Top Ten World's Leading Orthopedics Companies 3
Fine pointed grooved jaws with smooth curve from tip to finger grip style handle. Dull finish....
Coibri handle. Pierse tips with 6 mm platform. 2.5 mm angled tips. Manufactured in titanium....
Straight shafts with heavy 1 x 2 teeth. Non-magnetic with serrated handle and polished finish....
Straight shafts with two point fixation. Tips separated by 3 mm, each tip has 0.12 mm, 1 x 2 teeth. Wide serrated handle with dull finish....
Medicine Products: