Navigation Links
Process found to play role in rheumatoid arthritis could lead to new treatment
Date:1/29/2009

Although the origin of rheumatoid arthritis (RA) remains unclear, bioactive proteins known as cytokines, particularly TNFα and IL-6, which are involved in inflammation, play a major role in the disease by contributing to joint and tissue destruction. Placenta growth factor (PIGF), another cytokine, has been thought to be critical for a new blood vessel formation in the placenta to sufficiently deliver oxygen and nutrients to fetus. A new study examined the effects of PIGF on the inflammatory process of RA. The results suggest that PIGF may play an important role in inflammation in RA joints. The study was published in the February issue of Arthritis & Rheumatism (http://www3.interscience.wiley.com/journal/76509746/home).

Led by Wan-Uk Kim of Catholic University of Korea inSeoul, Korea, researchers analyzed blood and synovial fluid cells from RA patients and healthy controls and found that synovial cells were the major source of PIGF production in RA patients and that PIGF stimulates TNFα and IL-6 production. They also found that the PlGF-induced increases in TNFα and IL-6 production may be caused by high levels of flt-1, a PlGF receptor, which are linked to the inflammatory response of RA patients. In addition, the researchers identified a novel peptide to inhibit PlGF action. When injected into arthritic mice, this peptide reduced the severity of arthritis and prevented its progression. They also found that elimination of PIGF gene in mice prevented the development of antibody-induced arthritis.

The peptide they identified inhibits binding of PIGF to its receptor flt-1and could be valuable from a clinical standpoint, since it is easily synthesized and does not elicit unwanted immune response.

"These findings provide new insight into the pathogenic mechanism of RA and emphasize the importance of PIGF and flt-1 as potential candidates for therapy, in addition to their being a common cue of angiogenesis and the inflammatory process," the authors conclude. They are currently conducting research to improve the activity of the anti-flt-1 peptide by modifying its structure and length.


'/>"/>

Contact: Sean Wagner
medicalnews@bos.blackwellpublishing.com
781-388-8550
Wiley-Blackwell
Source:Eurekalert

Related medicine news :

1. Brain imaging reveals breakdown of normal emotional processing
2. NYU study points to lasting impact of mild hearing loss on neurological processes
3. Pharmaceutical Manufacturing Quality: Optimizing Your Internal Process for FDA Compliance
4. MedImmune Resolves FDA Observations Regarding Manufacturing Process for FluMist(R)
5. Delhaize Group Selects Trintechs AssureNET GL to Improve Compliance Process Efficiency
6. Labopharm provides update on U.S. regulatory process for once-daily Tramadol
7. BioProcessors Launches SimCell(TM) Services to Meet Increased Customer Demand
8. Orthofix International Acquires InSWing(TM) Interspinous Process Spacer
9. Cruel Deaths in Mexico a Result of Closing U.S. Horse Processing Plants: AVMA
10. Green Pet Products Introduces a New, Innovative Process to the Small Animal and Bird Litter/Bedding Category
11. ThermoGenesis Announces 510(k) Clearance for AutoXpress(TM) Cord Blood Processing System
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/27/2017)... ... ... Miro is the ultimate smart media center that offers a fascinating home ... and much more apps for user exploration. Its innovative acoustic design with premium speakers ... 720 provides crisp images with remarkable clarity and color. The WiFi connection enables its ...
(Date:2/27/2017)... ... 27, 2017 , ... Texas based retail electric company Discount ... RCE (Residential Customer Equivalent) count exceeds 150,000. , Discount Power was ... and 2,250 RCEs at the time of acquisition. In the three years since ...
(Date:2/27/2017)... ... February 27, 2017 , ... Silicon Valley ... to announce a new informational post on robotic hair transplantation. San Francisco residents ... hair transplant and Follicular Unit Transplantation (FUT) can sound similar. Either treatment can ...
(Date:2/27/2017)... ... , ... New Jersey ranks among the top five states in the entire ... for advanced services is growing. , Project WE vs C is a focused ... their non-profit partners in their fight against cancer and in support of their shared ...
(Date:2/26/2017)... ... February 26, 2017 , ... Today, A' Design Awards ... of International Social Design Awards. , The 7th A' Social Design Award ... and Institutions worldwide with realized projects and conceptual works. , The first phase ...
Breaking Medicine News(10 mins):
(Date:2/27/2017)... 27, 2017 Halyard Health, Inc. (NYSE: ... and provided its 2017 outlook and related key planning assumptions. ... $410 million, a 2 percent increase compared to the prior ... 2016 was $10 million compared to net income of $15 ... net income was $24 million compared to adjusted net income ...
(Date:2/27/2017)... , Feb. 27, 2017 Mederi Therapeutics ... 28 studies, representing 2468 patients who received  Stretta ... study entitled, " Systematic Review and Meta-Analysis of ... Radiofrequency for Treatment of Gastroesophageal Reflux Disease ", was ... Ronnie Fass , MD, head of the ...
(Date:2/27/2017)... 27, 2017   Royal Philips (NYSE: ... leader in health technology, today announced 510(k) clearance ... to market its ElastQ Imaging capability, further expanding ... systems. ElastQ Imaging enables simultaneous imaging of tissue ... for the diagnosis of various liver conditions. With ...
Breaking Medicine Technology: