Navigation Links
Probiotics affect metabolism, says new study

Probiotics, such as yoghurt drinks containing live bacteria, have a tangible effect on the metabolism, according to the results of a new study published today (Tuesday 15 January) in the journal Molecular Systems Biology.

The research is the first to look in detail at how probiotics change the biochemistry of bugs known as gut microbes, which live in the gut and which play an important part in a persons metabolic makeup. Different people have different types of gut microbes inside them and abnormalities in some types have recently been linked to diseases such as diabetes and obesity.

For the study, researchers from Imperial College London and Nestl Research Center, Lausanne, Switzerland, gave two different types of probiotic drink to mice that had been transplanted with human gut microbes. Probiotics contain so-called friendly bacteria and there is some evidence to suggest that adding friendly bacteria to the gut can help the digestive system.

The researchers compared the levels of different metabolites in the liver, blood, urine, and faeces, of mice who had received treatment with probiotics and those that had not.

They found that treatment with probiotics had a whole range of biochemical effects and that these effects differed markedly between the two probiotic strains, Lactobacillus paracasei and Lactobacillus rhamnosus. Adding friendly bacteria changed the makeup of the bugs in the gut, not only because this increased the number of such bacteria, but also because the friendly bacteria worked with other bacteria in the gut, amplifying their effects.

One of the many biochemical changes observed by the researchers was a change in how mice treated with probiotics metabolised bile acids. These acids are made by the liver and their primary function is to emulsify fats in the upper gut. If probiotics can influence the way in which bile acids are metabolised, this means they could change how much fat the body is able to absorb.

Professor Jeremy Nicholson, corresponding author on the study from the Department of Biomolecular Medicine at Imperial College, explained Some argue that probiotics cant change your gut microflora - whilst there are at least a billion bacteria in a pot of yoghurt, there are a hundred trillion in the gut, so youre just whistling in the wind.

Our study shows that probiotics can have an effect and they interact with the local ecology and talk to other bacteria. Were still trying to understand what the changes they bring about might mean, in terms of overall health, but we have established that introducing friendly bacteria can change the dynamics of the whole population of microbes in the gut, he said.

The researchers hope their new insights about how probiotics and gut microbes interact will ultimately enable the development of new probiotic therapies, which can be tailored for people with different conditions and different metabolic makeups.

Dr. Sunil Kochhar, another author on the study from the Nestl Research Center, added: Understanding changes in the molecular events triggered by the so-called beneficial bacteria in the host metabolism is an important prerequisite in our efforts to develop customized nutritional solutions to maintain and/or enhance our consumers health and wellness at an individual level. The results of this study are highly promising to address personalized nutrition.


Contact: Laura Gallagher
Imperial College London

Related medicine news :

1. Probiotics Play Critical Role in Pediatric Health and Immunity
2. Naked Juice Brings Consumers Happiness by the Billions With First 100% Juice Smoothie Containing Probiotics
3. Extreme obesity affects chances of kidney transplantation
4. Blue Shield of California Reaching Out to Members Affected by California Storms
5. Race, Gender Affect Laryngeal Cancer Survival
6. Where vets served affects frequency of ER visits but not hospital stays
7. American Society for Aesthetic Plastic Surgery and American Society of Plastic Surgeons Offer Patient Advisory for those Affected by Fig LipoDissolve Closures
8. Household chemical may affect breast development
9. Got sugar? Glucose affects our ability to resist temptation
10. Do medical schools affect the way future doctors interact with drug companies?
11. Childhood sleep-disordered breathing disproportionately affects obese and African-Americans
Post Your Comments:
(Date:11/27/2015)... , ... November 27, 2015 , ... ProSidebar: Fashion ... Final Cut Pro X. With ProSidebar: Fasion, video editors can easily add an ... as a minimalist title opener. Utilize presets featuring self-animating drop zones, lines, bars, ...
(Date:11/27/2015)... ... November 27, 2015 , ... Intellitec Solutions announced today ... Group (MSDSLUG). Recognized as Microsoft’s official group for end users of Dynamics SL ... users, partners, industry experts and representatives. Intellitec Solutions’ membership status demonstrates their ongoing ...
(Date:11/27/2015)... Karnataka (PRWEB) , ... November 27, 2015 , ... ... world, Health-E-minds, an innovative online platform for mental health and wellness consultation, has ... , This partnership will bridge the knowledge gap experienced by parents and bring ...
(Date:11/27/2015)... ... 27, 2015 , ... Dr. Thomas Dunlap and Dr. Patrick ... Bierbaum with Emergency Medicine at St., Joseph Health System’s Santa Rosa Memorial Hospital ... present in similar ways and require time-critical intervention to avoid large area heart damage ...
(Date:11/26/2015)... ... November 26, 2015 , ... Patients at Serenity Point Recovery, ... together on Thanksgiving Day to share the things that they are most grateful ... Point YouTube channel, patients displayed what they wrote on index cards, describing the ...
Breaking Medicine News(10 mins):
(Date:11/27/2015)... DUBLIN , Nov. 27, 2015 Research ... of the "Global Intrauterine Devices Market 2015-2019" ... --> In this report, the author ... intrauterine devices market for 2015-2019. To calculate the market ... of following type of products: Hormonal IUDs and copper ...
(Date:11/26/2015)... 26, 2015 --> ... approach blends immunotherapy with Bremachlorin-photodynamic therapy for advanced cancer. ... blends immunotherapy with Bremachlorin-photodynamic therapy for advanced cancer. ... blends immunotherapy with Bremachlorin-photodynamic therapy for advanced cancer. ... found that immunotherapy can be efficiently combined with photodynamic ...
(Date:11/26/2015)... DUBLIN , Nov. 26, 2015 ... the addition of the "2016 Future Horizons ... Monitoring (TDM) Market: Supplier Shares, Country Segment Forecasts, ... offering. --> ... comprehensive analysis of the Japanese therapeutic drug monitoring ...
Breaking Medicine Technology: