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Probiotic-derived treatment offers new hope for premature babies
Date:2/13/2013

possibility that the two together could have a greater synergistic effect, it does suggest that B. infantis may be primarily responsible for the anti-inflammatory effect observed.

Importance of the Findings

While NEC is a complex disease, the authors suggest that this study addresses a critical component of the problem. If purified secretions from probiotic bacteria can reduce the severity and incidence of NEC in very low birthweight infants, it could represent a very promising new avenue of clinical research, they say, and may ultimately change the standard of care for these infants.

They add that these promising findings could lead to future clinical studies to investigate these factors in greater detail. Eventually, the researchers add, secretions from probiotic bacteria may help prevent the development of NEC in premature infants in the U.S., potentially saving thousands of lives each year.

"The specific mechanisms by which probiotic secretions reduce inflammation need to be further investigated and safety data will need to be established in live animal models of NEC," says Ganguli. "Once established, these factors should be then investigated as a standard preventive strategy in a randomized, placebo-controlled clinical trial."


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Contact: Donna Krupa
301-634-7209
American Physiological Society
Source:Eurekalert

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